Search Results - "Chu, Kevin S"

Scalable Manufacture of Built-to-Order Nanomedicine: Spray-Assisted Layer-by-Layer Functionalization of PRINT Nanoparticles by Morton, Stephen W., Herlihy, Kevin P., Shopsowitz, Kevin E., Deng, Zhou J., Chu, Kevin S., Bowerman, Charles J., DeSimone, Joseph M., Hammond, Paula T.

“…Scalable methods, PRINT particle fabrication, and spray‐assisted Layer‐by‐Layer deposition are combined to generate uniform and functional nanotechnologies…”
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Nanoparticle drug loading as a design parameter to improve docetaxel pharmacokinetics and efficacy by Chu, Kevin S, Schorzman, Allison N, Finniss, Mathew C, Bowerman, Charles J, Peng, Lei, Luft, James C, Madden, Andrew J, Wang, Andrew Z, Zamboni, William C, DeSimone, Joseph M

“…Abstract Nanoparticle (NP) drug loading is one of the key defining characteristics of an NP formulation. However, the effect of NP drug loading on therapeutic…”
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Plasma, tumor and tissue pharmacokinetics of Docetaxel delivered via nanoparticles of different sizes and shapes in mice bearing SKOV-3 human ovarian carcinoma xenograft by Chu, Kevin S., BS, Hasan, Warefta, PhD, Rawal, Sumit, PhD, Walsh, Mark D., PharmD, Enlow, Elizabeth M., PhD, Luft, J. Christopher, PhD, Bridges, Arlene S., PhD, Kuijer, Jennifer L., BS, Napier, Mary E., PhD, Zamboni, William C., PharmD, PhD, DeSimone, Joseph M., PhD

“…Abstract The particle fabrication technique PRINT® was used to fabricate monodisperse size and shape specific poly(lactide-co-glycolide) particles loaded with…”
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Docetaxel-Loaded PLGA Nanoparticles Improve Efficacy in Taxane-Resistant Triple-Negative Breast Cancer by Bowerman, Charles J, Byrne, James D, Chu, Kevin S, Schorzman, Allison N, Keeler, Amanda W, Sherwood, Candice A, Perry, Jillian L, Luft, James C, Darr, David B, Deal, Allison M, Napier, Mary E, Zamboni, William C, Sharpless, Norman E, Perou, Charles M, DeSimone, Joseph M

“…Novel treatment strategies, including nanomedicine, are needed for improving management of triple-negative breast cancer. Patients with triple-negative breast…”
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Particle Replication in Nonwetting Templates Nanoparticles with Tumor Selective Alkyl Silyl Ether Docetaxel Prodrug Reduces Toxicity by Chu, Kevin S, Finniss, Mathew C, Schorzman, Allison N, Kuijer, Jennifer L, Luft, J. Christopher, Bowerman, Charles J, Napier, Mary E, Haroon, Zishan A, Zamboni, William C, DeSimone, Joseph M

“…Delivery systems designed to have triggered release after passively targeting the tumor may improve small molecule chemotherapeutic delivery. Particle…”
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Metronomic docetaxel in PRINT nanoparticles and EZH2 silencing have synergistic antitumor effect in ovarian cancer by Gharpure, Kshipra M, Chu, Kevin S, Bowerman, Charles J, Miyake, Takahito, Pradeep, Sunila, Mangala, Selanere L, Han, Hee-Dong, Rupaimoole, Rajesha, Armaiz-Pena, Guillermo N, Rahhal, Tojan B, Wu, Sherry Y, Luft, J Christopher, Napier, Mary E, Lopez-Berestein, Gabriel, DeSimone, Joseph M, Sood, Anil K

“…The purpose of this study was to investigate the antitumor effects of a combination of metronomic doses of a novel delivery vehicle, PLGA-PRINT nanoparticles…”
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Scalable Manufacture of Built-to-Order Nanomedicine: Spray-Assisted Layer-by-Layer Functionalization of PRINT Nanoparticles (Adv. Mater. 34/2013) by Morton, Stephen W., Herlihy, Kevin P., Shopsowitz, Kevin E., Deng, Zhou J., Chu, Kevin S., Bowerman, Charles J., DeSimone, Joseph M., Hammond, Paula T.

“…Scalable methods, PRINT particle fabrication, and spray‐assisted layer‐by‐layer deposition, are combined by Paula Hammond, Joseph DeSimone and co‐workers on…”
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Abstract 5403: Metronomic docetaxel in PRINT nanoparticles and EZH2 silencing have synergistic antitumor effect in ovarian cancer by Gharpure, Kshipra M., Chu, Kevin S., Bowerman, Charles, Miyake, Takahito, Pradeep, Sunila, Mangala, Lingegowda S., Han, Hee-Dong, Rupaimoole, Rajesha, Wu, Sherry Y., Dalton, Heather J., Napier, Mary E., Lopez-Berestein, Gabriel, DeSimone, Joseph M., Sood, Anil K.

“…Abstract Purpose: The purpose of this study was to investigate the combined antitumor effects of metronomic docetaxel-containing PLGA-PRINT nanoparticles and…”
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Distal Ureteric Stones and Tamsulosin: A Double-Blind, Placebo-Controlled, Randomized, Multicenter Trial by Furyk, Jeremy S., MBBS MPH&TM, Chu, Kevin, MBBS MS, Banks, Colin, MBBS, Greenslade, Jaimi, PhD, Keijzers, Gerben, MBBS PhD, Thom, Ogilvie, MBBS, Torpie, Tom, MBBS, Dux, Carl, MBBS, Narula, Rajan, MBBS

“…Study objective We assess the efficacy and safety of tamsulosin compared with placebo as medical expulsive therapy in patients with distal ureteric stones less…”
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BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes by Hong, Ting-Ting, MD, PhD, Smyth, James W., PhD, Chu, Kevin Y., BS, Vogan, Jacob M., BS, Fong, Tina S., BA, Jensen, Brian C., MD, Fang, Kun, PhD, Halushka, Marc K., MD, PhD, Russell, Stuart D., MD, Colecraft, Henry, PhD, Hoopes, Charles W., MD, Ocorr, Karen, PhD, Chi, Neil C., MD, PhD, Shaw, Robin M., MD, PhD

“…Background Heart failure is a growing epidemic, and a typical aspect of heart failure pathophysiology is altered calcium transients. Normal cardiac calcium…”
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Spectrophotometry or Visual Inspection to Most Reliably Detect Xanthochromia in Subarachnoid Hemorrhage: Systematic Review by Chu, Kevin, MBBS, MS, Hann, Angus, MBBS (Hons), Greenslade, Jaimi, PhD, Williams, Julian, MBBS, Brown, Anthony, MBChB

“…Study objective We assess the sensitivity and specificity of xanthochromia as adjudicated by visual inspection and spectrophotometry at predicting the presence…”
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Systemic Inflammatory Response Syndrome, Quick Sequential Organ Function Assessment, and Organ Dysfunction by Williams, Julian M., MBBS, Greenslade, Jaimi H., PhD, McKenzie, Juliet V., MBBS, Chu, Kevin, MBBS, MS, Brown, Anthony F.T., MBChB, Lipman, Jeffrey, MD (research)

“…Background A proposed revision of sepsis definitions has abandoned the systemic inflammatory response syndrome (SIRS), defined organ dysfunction as an increase…”
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A Randomized Controlled Trial Comparing Patient-Controlled and Physician-Controlled Sedation in the Emergency Department by Bell, Anthony, MBBS, FACEM, Lipp, Trent, MBBS, BSc, Greenslade, Jaimi, PhD, Chu, Kevin, MBBS, MS, FACEM, Rothwell, Sean, MBBS, FACEM, Duncan, Alison, RN

“…Study objective We compare patient-controlled sedation (PCS) and emergency physician–controlled sedation (EPCS) with respect to propofol requirements, depth of…”
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