Search Results - "Chu, Jianlin"

An Extended Transcriptional Network for Pluripotency of Embryonic Stem Cells by Kim, Jonghwan, Chu, Jianlin, Shen, Xiaohua, Wang, Jianlong, Orkin, Stuart H.

“…Much attention has focused on a small set of transcription factors that maintain human or mouse embryonic stem (ES) cells in a pluripotent state. To gain a…”
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A Myc Network Accounts for Similarities between Embryonic Stem and Cancer Cell Transcription Programs by Kim, Jonghwan, Woo, Andrew J., Chu, Jianlin, Snow, Jonathan W., Fujiwara, Yuko, Kim, Chul Geun, Cantor, Alan B., Orkin, Stuart H.

“…c-Myc (Myc) is an important transcriptional regulator in embryonic stem (ES) cells, somatic cell reprogramming, and cancer. Here, we identify a Myc-centered…”
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Charge Variants Characterization of Co-Formulated Antibodies by Three-Dimensional Liquid Chromatography-Mass Spectrometry by Jin, Xiaoqing, Chen, Luna, Chu, Jianlin, He, Bingfang

“…Co-formulated antibodies can bring clinical benefits to patients by combining two or more antibodies in a single dosage form. However, the quality analysis of…”
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Efficient Synthesis of Purine Nucleoside Analogs by a New Trimeric Purine Nucleoside Phosphorylase from Aneurinibacillus migulanus AM007 by Liu, Gaofei, Cheng, Tiantong, Chu, Jianlin, Li, Sui, He, Bingfang

“…Purine nucleoside phosphorylases (PNPs) are promising biocatalysts for the synthesis of purine nucleoside analogs. Although a number of PNPs have been…”
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Comparison of Four Rapid N-Glycan Analytical Methods and Great Application Potential in Cell Line Development by Jin, Xiaoqing, Chu, Jianlin, He, Bingfang

“…N-glycan, a critical quality attribute (CQA) of monoclonal antibodies, profoundly impacts potency, immunogenicity, safety, and clinical efficiency. Therefore,…”
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A protein interaction network for pluripotency of embryonic stem cells by Levasseur, Dana N, Rao, Sridhar, Shen, Xiaohua, Orkin, Stuart H, Wang, Jianlong, Chu, Jianlin, Theunissen, Thorold W

“…Embryonic stem (ES) cells are pluripotent and of therapeutic potential in regenerative medicine. Understanding pluripotency at the molecular level should…”
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Mesenchymal stem cell population derived from human pluripotent stem cells displays potent immunomodulatory and therapeutic properties by Kimbrel, Erin A, Kouris, Nicholas A, Yavanian, Gregory J, Chu, Jianlin, Qin, Yu, Chan, Ann, Singh, Ram P, McCurdy, Deborah, Gordon, Lynn, Levinson, Ralph D, Lanza, Robert

“…Mesenchymal stem cells (MSCs) are being tested in a wide range of human diseases; however, loss of potency and inconsistent quality severely limit their use…”
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Engineering Substrate Promiscuity of Nucleoside Phosphorylase Via an Insertions–Deletions Strategy by Liu, Gaofei, Wang, Jialing, Chu, Jianlin, Jiang, Tianyue, Qin, Song, Gao, Zhen, He, Bingfang

“…Nucleoside phosphorylases (NPs) are the key enzymes in the nucleoside metabolism pathway and are widely employed for the synthesis of nucleoside analogs, which…”
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An efficient novel glycosylation of flavonoid by β-fructosidase resistant to hydrophilic organic solvents by Wu, Xueming, Chu, Jianlin, Wu, Bin, Zhang, Sen, He, Bingfang

“…[Display omitted] ► An effective approach was developed to isolate solvent-stable glycosidase. ► The solvent-stable β-fructosidase with acceptor specificity of…”
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Biocatalysis for Rare Ginsenoside Rh2 Production in High Level with Co-Immobilized UDP-Glycosyltransferase Bs-YjiC Mutant and Sucrose Synthase AtSuSy by Jianlin Chu, Jiheng Yue, Song Qin, Yuqiang Li, Bin Wu, Bingfang He

“…Rare ginsenoside Rh2 exhibits diverse pharmacological effects. UDP-glycosyltransferase (UGT) catalyzed glycosylation of protopanaxadiol (PPD) has been of…”
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Exploiting the Reversibility of GTBP1 Catalyzed One-pot Reactions for the Synergistical Synthesis of Ponasterone A and Phenolic Glycosides by Li, Yuqiang, Li, Bingfeng, Chen, Tianyi, Wu, Bin, Chu, Jianlin, He, Bingfang

“…In the process of glycosyltransferase-catalyzed transglycosylation, the synthesis of uridine diphosphate sugars is generally thermodynamically disfavored. This…”
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Human ESC-Derived MSCs Outperform Bone Marrow MSCs in the Treatment of an EAE Model of Multiple Sclerosis by Wang, Xiaofang, Kimbrel, Erin A., Ijichi, Kumiko, Paul, Debayon, Lazorchak, Adam S., Chu, Jianlin, Kouris, Nicholas A., Yavanian, Gregory J., Lu, Shi-Jiang, Pachter, Joel S., Crocker, Stephen J., Lanza, Robert, Xu, Ren-He

“…Current therapies for multiple sclerosis (MS) are largely palliative, not curative. Mesenchymal stem cells (MSCs) harbor regenerative and immunosuppressive…”
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Lipase immobilization on functionalized mesoporous TiO 2 : Specific adsorption, hyperactivation and application in cinnamyl acetate synthesis by Gao, Zhen, Chu, Jianlin, Jiang, Tianyue, Xu, Tingting, Wu, Bin, He, Bingfang

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Efficient glucosylation of flavonoids by organic solvent-tolerant Staphylococcus saprophyticus CQ16 in aqueous hydrophilic media by Chu, Jianlin, Wu, Xueming, Li, Bo, He, Bingfang

“…•A DMSO-tolerant bacterium S. saprophyticus CQ16 capable of glucosylating daidzein was isolated.•The glucosyltransferase from strain CQ16 showed broad…”
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A Versatile Approach for Enzyme Immobilization Using Chemically Modified 3D-Printed Scaffolds by Ye, Jiajie, Chu, Tianshu, Chu, Jianlin, Gao, Bingbing, He, Bingfang

“…The tedious preparation procedures and difficulty in free structure formation and recycling have restricted the widespread application of existing enzyme…”
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Evidence That C Promoter-binding Factor 1 Binding Is Required for Notch-1-mediated Repression of Activator Protein-1 by Chu, Jianlin, Bresnick, Emery H.

“…Cell fate determination in invertebrate and vertebrate systems is regulated by the Notch signaling pathway. Four mammalian Notch genes, Notch 1–4, encode…”
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Modern evolution of paper-based analytical devices for wearable use: from disorder to order by Chu, Tianshu, Chu, Jianlin, Gao, Bingbing, He, Bingfang

“…Paper devices have attracted great attention for their rapid development in multiple fields, such as life sciences, biochemistry, and materials science. When…”
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Repression of Activator Protein-1-mediated Transcriptional Activation by the Notch-1 Intracellular Domain by Chu, Jianlin, Jeffries, Shawn, Norton, Jason E., Capobianco, Anthony J., Bresnick, Emery H.

“…Developmental decisions that control cell fate are commonly regulated by the Notch signaling pathway. Activation of transmembrane Notch receptors results in…”
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Personalized and Programmable Microneedle Dressing for Promoting Wound Healing by Wang, Yuqiu, Lu, Huihui, Guo, Maoze, Chu, Jianlin, Gao, Bingbing, He, Bingfang

“…Microneedle (MN) dressings, with the ability of transdermal drug delivery, have played an essential role in the field of wound healing. However, patients may…”
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Fitting replacement of signal peptide for highly efficient expression of three penicillin G acylases in E. coli by Pan, Xin, Yu, Qi, Chu, Jianlin, Jiang, Tianyue, He, Bingfang

“…High level expression of penicillin G acylase (PGA) in Escherichia coli is generally constricted by a complex maturation process and multiple limiting steps…”
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