Search Results - "Chu, Eagle"

Peptostreptococcus anaerobius Induces Intracellular Cholesterol Biosynthesis in Colon Cells to Induce Proliferation and Causes Dysplasia in Mice by Tsoi, Ho, Chu, Eagle SH, Zhang, Xiang, Sheng, Jianqiu, Nakatsu, Daniel, Ng, Siew C, Chan, Anthony WH, Chan, Francis KL, Sung, Joseph JY, Yu, Jun

“…Abstract Background & Aims Stool samples from patients with colorectal cancer (CRC) have a higher abundance of Peptostreptococcus anaerobius than stool from…”
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CXC chemokine receptor 3 promotes steatohepatitis in mice through mediating inflammatory cytokines, macrophages and autophagy by Zhang, Xiang, Han, Juqiang, Man, Kwan, Li, Xiaoxing, Du, Jinghua, Chu, Eagle S.H, Go, Minnie Y.Y, Sung, Joseph J.Y, Yu, Jun

“…Graphical abstract…”
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Altered gut microbiome composition by appendectomy contributes to colorectal cancer by Shi, Feiyu, Liu, Gaixia, Lin, Yufeng, Guo, Cosmos liutao, Han, Jing, Chu, Eagle S. H., Shi, Chengxin, Li, Yaguang, Zhang, Haowei, Hu, Chenhao, Liu, Ruihan, He, Shuixiang, Guo, Gang, Chen, Yinnan, Zhang, Xiang, Coker, Olabisi Oluwabukola, Wong, Sunny Hei, Yu, Jun, She, Junjun

“…Appendectomy impacts the homeostasis of gut microbiome in patients. We aimed to study the role of appendectomy in colorectal cancer (CRC) risk through causing…”
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CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis by Zhang, Xiang, Shen, Jiayun, Man, Kwan, Chu, Eagle S.H, Yau, Tung On, Sung, Joanne C.Y, Go, Minnie Y.Y, Deng, Jun, Lu, Liwei, Wong, Vincent W.S, Sung, Joseph J.Y, Farrell, Geoffrey, Yu, Jun

“…Background & Aims Perpetuate liver inflammation is crucial in the pathogenesis of non-alcoholic steatohepatitis (NASH). Expression of CXCL10, a…”
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Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling by Liang, Jessie Qiaoyi, Teoh, Narcissus, Xu, Lixia, Pok, Sharon, Li, Xiangchun, Chu, Eagle S. H., Chiu, Jonathan, Dong, Ling, Arfianti, Evi, Haigh, W. Geoffrey, Yeh, Matthew M., Ioannou, George N., Sung, Joseph J. Y., Farrell, Geoffrey, Yu, Jun

“…The underlining mechanisms of dietary cholesterol and nonalcoholic steatohepatitis (NASH) in contributing to hepatocellular carcinoma (HCC) remain undefined…”
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Defective lysosomal clearance of autophagosomes and its clinical implications in nonalcoholic steatohepatitis by Wang, Xiaojuan, Zhang, Xiang, Chu, Eagle S. H., Chen, Xiaoting, Kang, Wei, Wu, Feng, To, Ka‐Fai, Wong, Vincent W. S., Chan, Henry L. Y., Chan, Matthew T. V., Sung, Joseph J. Y., Wu, William K. K., Yu, Jun

“…Autophagic impairment is implicated in nonalcoholic fatty liver disease (NAFLD), but the molecular mechanism is unclear. We found that autophagic flux was…”
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Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumour immunity by Long, Xiaohang, Wong, Chi Chun, Tong, Li, Chu, Eagle S. H., Ho Szeto, Chun, Go, Minne Y. Y., Coker, Olabisi Oluwabukola, Chan, Anthony W. H., Chan, Francis K. L., Sung, Joseph J. Y., Yu, Jun

“…Emerging evidence implicates a role of the gut microbiota in colorectal cancer (CRC). Peptostreptococcus anaerobius ( P. anaerobius ) is an anaerobic bacterium…”
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microRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway by Wang, Jia, Chu, Eagle S H, Chen, Hai-Yong, Man, Kwan, Go, Minnie Y Y, Huang, Xiao Ru, Lan, Hui Yao, Sung, Joseph J Y, Yu, Jun

“…microRNA-29b (miR-29b) is known to be associated with TGF-β-mediated fibrosis, but the mechanistic action of miR-29b in liver fibrosis remains unclear and is…”
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High Soluble Fiber Promotes Colorectal Tumorigenesis Through Modulating Gut Microbiota and Metabolites in Mice by Yang, Jia, Wei, Hong, Lin, Yufeng, Chu, Eagle S.H., Zhou, Yunfei, Gou, Hongyan, Guo, Shang, Lau, Harry C.H., Cheung, Alvin H.K., Chen, Huarong, To, Ka Fei, Sung, Joseph J.Y., Wang, Yong, Yu, Jun

“…Dietary fibers are mainly fermented by the gut microbiota, but their roles in colorectal cancer (CRC) are largely unclear. Here, we investigated the…”
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Sodium Channel Subunit SCNN1B Suppresses Gastric Cancer Growth and Metastasis via GRP78 Degradation by Qian, Yun, Wong, Chi Chun, Xu, Jiaying, Chen, Huarong, Zhang, Yanquan, Kang, Wei, Wang, Hua, Zhang, Li, Li, Weilin, Chu, Eagle S H, Go, Minnie Y Y, Chiu, Philip W Y, Ng, Enders K W, Chan, Francis K L, Sung, Joseph J Y, Si, Jianmin, Yu, Jun

“…There remains a paucity of functional biomarkers in gastric cancer. Here, we report the identification of the sodium channel subunit SCNN1B as a candidate…”
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Parabacteroides distasonis uses dietary inulin to suppress NASH via its metabolite pentadecanoic acid by Wei, Wenchao, Wong, Chi Chun, Jia, Zhongjun, Liu, Weixin, Liu, Changan, Ji, Fenfen, Pan, Yasi, Wang, Feixue, Wang, Guoping, Zhao, Liuyang, Chu, Eagle S. H., Zhang, Xiang, Sung, Joseph J. Y., Yu, Jun

“…Non-alcoholic steatohepatitis (NASH) is the severe form of non-alcoholic fatty liver disease, and is characterized by liver inflammation and fat accumulation…”
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Fecal microbial DNA markers serve for screening colorectal neoplasm in asymptomatic subjects by Liang, Jessie Qiaoyi, Wong, Sunny H, Szeto, Chun Ho, Chu, Eagle SH, Lau, Harry C, Chen, Yingxuan, Fang, Jingyuan, Yu, Jun, Sung, Joseph JY

“…Background and Aim We have previously shown that fecal microbial markers might be useful for non‐invasive diagnosis of colorectal cancer (CRC) and adenoma…”
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Bone marrow‐derived macrophage contributes to fibrosing steatohepatitis through activating hepatic stellate cells by Han, Juqiang, Zhang, Xiang, Lau, Jennie K‐C, Fu, Kaili, Lau, Harry CH, Xu, Weiqi, Chu, Eagle SH, Lan, Huiyao, Yu, Jun

“…The role of macrophages in fibrosing steatohepatitis is largely unclear. We characterized the origin and molecular mechanisms of macrophages and its targeted…”
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Inhibitory role of peroxisome proliferator‐activated receptor gamma in hepatocarcinogenesis in mice and in vitro by Yu, Jun, Shen, Bo, Chu, Eagle S. H., Teoh, Narci, Cheung, Kin‐Fai, Wu, Chung‐Wah, Wang, Shiyan, Lam, Cleo N. Y., Feng, Hai, Zhao, Junhong, Cheng, Alfred S. L., To, Ka‐Fai, Chan, Henry L. Y., Sung, Joseph J. Y.

“…Although peroxisome proliferator‐activated receptor gamma (PPARγ) agonist have been shown to inhibit hepatocellular carcinoma (HCC) development, the role of…”
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O‐GlcNAcylation inhibits hepatic stellate cell activation by Li, Rui, Ong, Qunxiang, Wong, Chi Chun, Chu, Eagle S H, Sung, Joseph J Y, Yang, Xiaoyong, Yu, Jun

“…Background and Aim Protein O‐GlcNAcylation is a critical post‐translational modification regulating gene expression and fundamental cell functions. O‐GlcNAc…”
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Epigenetic inactivation of BCL6B, a novel functional tumour suppressor for gastric cancer, is associated with poor survival by Xu, Lixia, Li, Xiaoxing, Chu, Eagle S H, Zhao, Guijun, Go, Minnie Y Y, Tao, Qian, Jin, Hongchuan, Zeng, Zhirong, Sung, Joseph J Y, Yu, Jun

“…Using genome-wide promoter methylation assay, B cell CLL/lymphoma 6 member B (BCL6B) was found to be preferentially methylated in cancer. A study was…”
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Paired box gene 5 is a novel tumor suppressor in hepatocellular carcinoma through interaction with p53 signaling pathway by Liu, Weili, Li, Xiaoxing, Chu, Eagle S.H., Go, Minnie Y.Y., Xu, Lixia, Zhao, Guijun, Li, Lili, Dai, Ning, Si, Jianmin, Tao, Qian, Sung, Joseph J.Y., Yu, Jun

“…The paired box 5 (PAX5) is a member of PAX transcription factors family involved in the regulation of embryonic development. However, the role of PAX5 in…”
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T1ρ MR Imaging Is Sensitive to Evaluate Liver Fibrosis: An Experimental Study in a Rat Biliary Duct Ligation Model by WANG, Yi-Xiang J, JING YUAN, CHU, Eagle S. H, GO, Minnie Y. Y, HUA HUANG, AHUJA, Anil T, SUNG, Joseph J. Y, JUN YU

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Peroxisome proliferator activated receptor alpha inhibits hepatocarcinogenesis through mediating NF-κB signaling pathway by Zhang, Ning, Chu, Eagle S H, Zhang, Jingwan, Li, Xiaoxing, Liang, Qiaoyi, Chen, Jie, Chen, Minhu, Teoh, Narci, Farrell, Geoffrey, Sung, Joseph J Y, Yu, Jun

“…Peroxisome proliferator-activated receptor alpha (PPARα) ligands have been reported to suppress cancer growth. However, the role of PPARα in…”
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High Sensitivity of Shotgun Metagenomic Sequencing in Colon Tissue Biopsy by Host DNA Depletion by Cheng, Wing Yin, Liu, Wei-Xin, Ding, Yanqiang, Wang, Guoping, Shi, Yu, Chu, Eagle S.H., Wong, Sunny, Sung, Joseph J.Y., Yu, Jun

“…The high host genetic background of tissue biopsies hinders the application of shotgun metagenomic sequencing in characterizing the tissue microbiota. We…”
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