Search Results - "Chu, Duan"

Nonsynonymous, synonymous and nonsense mutations in human cancer-related genes undergo stronger purifying selections than expectation by Chu, Duan, Wei, Lai

“…Nonsynonymous mutations change the protein sequences and are frequently subjected to natural selection. The same goes for nonsense mutations that introduce…”
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Genome-wide analysis on the maize genome reveals weak selection on synonymous mutations by Chu, Duan, Wei, Lai

“…Synonymous mutations are able to change the tAI (tRNA adaptation index) of a codon and consequently affect the local translation rate. Intuitively, one may…”
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Parsing the synonymous mutations in the maize genome: isoaccepting mutations are more advantageous in regions with codon co-occurrence bias by Chu, Duan, Wei, Lai

“…Synonymous mutations do not change amino acids but do sometimes change the tRNAs (anticodons) that decode a particular codon. An isoaccepting codon is a…”
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Context-dependent and -independent selection on synonymous mutations revealed by 1,135 genomes of Arabidopsis thaliana by Chu, Duan, Wei, Lai

“…Synonymous mutations do not alter the amino acids and therefore are regarded as neutral for a long time. However, they do change the tRNA adaptation index…”
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The chloroplast and mitochondrial C‐to‐U RNA editing in Arabidopsis thaliana shows signals of adaptation by Chu, Duan, Wei, Lai

“…C‐to‐U RNA editing is the conversion from cytidine to uridine at RNA level. In plants, the genes undergo C‐to‐U RNA modification are mainly chloroplast and…”
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Therapeutic effect of Keap1-Nrf2-ARE pathway-related drugs on age-related eye diseases through anti-oxidative stress by Cai, Zi-Yan, Liu, Ke, Duan, Xuan-Chu

“…Age-related eye diseases, including cataract, glaucoma, diabetic retinopathy (DR), and age-related macular degeneration (AMD), are the leading causes of vision…”
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Diastereoselective One‐Step Synthesis of 2‐Keto‐3‐deoxy‐d‐ glycero‐d‐galacto‐nononic acid (KDN) Analogues as Templates for the Development of Influenza Drugs by Laborda, Pedro, Wang, Su‐Yan, Lu, Ai‐Min, He, Meng, Duan, Xu‐Chu, Qian, Ying‐Juan, Jung, Yong‐Sam, Liu, Li, Voglmeir, Josef

“…Novel sialic acid scaffolds have great significance in the development of influenza neuraminidase inhibitors. Here the enzymatic synthesis of a wide range of…”
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Changes of optic nerve head microcirculation in high myopia by Tang, Wen-Quan, Luo, Yu-Lin, Wang, Xi-Lang, Duan, Xuan-Chu

“…To analyze the correlation of age, spherical equivalent (SE), and axial length (AL) with the microcirculation of optic nerve head (ONH) in high myopia (HM). In…”
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Application and prospect of gene chip in genetic breeding of livestock and poultry by Jia-Hao, Wang, Qing-Yao, Zhao, Yue-Ling, Zhou, Liang-Yu, Shi, Chu-Duan, Wang, Ying, Yu

“…Gene chip is a high-throughput technique for detecting specific DNA sequences by DNA or DNA-RNA complementary hybridization, among which SNP genotyping chips…”
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Biomechanics of the sclera and effects on intraocular pressure by Jia, Xu, Yu, Juan, Liao, Sheng-Hui, Duan, Xuan-Chu

“…Accumulating evidence indicates that glaucoma is a multifactorial neurodegenerative disease characterized by the loss of retinal ganglion cells （RGC）,…”
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Rosiglitazone inhibits TGF-β 1 induced activation of human Tenon fibroblasts via p38 signal pathway by Luo, Yong-Heng, Ouyang, Ping-Bo, Tian, Jiao, Guo, Xiao-Jian, Duan, Xuan-Chu

“…Transdifferentiation of human Tenon fibroblasts to myofibroblasts and subsequent deposition of extracellular matrix is a key step in the scarring after…”
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Histopathology and treatment of a huge overhanging filtering bleb by Ou-Yang, Ping-Bo, Qi, Xin, Duan, Xuan-Chu

“…The giant filtering bleb encroaching onto the corneal surface is a rare occurrence in our and other's clinical experience (Kapoor and Syed, Int. Ophthalmol…”
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The Establishment of Double-Transgenic Mice that Co-Express the appA and MxA Genes Mediated by Type A Spermatogonia In vivo by BAI, Li-jing, JU, Hui-ming, MU, Yu-lian, YANG, Shu-lin, REN, Hong-yan, AO, Hong, WANG, Chu-duan, LI, Kui

“…Type A spermatogonial stem cells are the only immortal diploid cells in the postnatal animal that undergo self-renewal through the lifetime of an animal and…”
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Discovery and Biochemical Characterization of the UDP-Xylose Biosynthesis Pathway in Sphaerobacter thermophilus by Gu, Bin, Laborda, Pedro, Wei, Shuang, Duan, Xu-Chu, Song, Hui-Bo, Liu, Li, Voglmeir, Josef

“…The biosynthesis of UDP-xylose requires the stepwise oxidation/ decarboxylation of UDP-glucose, which is catalyzed by the enzymes UDPglucuronic acid…”
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Pseudomonas putida Represses JA- and SA-Mediated Defense Pathways in Rice and Promotes an Alternative Defense Mechanism Possibly through ABA Signaling by Wang, Rui, Wang, Hai-Lin, Tang, Rui-Ping, Sun, Meng-Ying, Chen, Tang-Min, Duan, Xu-Chu, Lu, Xiao-Feng, Liu, Dong, Shi, Xin-Chi, Laborda, Pedro, Wang, Su-Yan

“…The signaling pathways induced by in rice plants at the early plant-rhizobacteria interaction stages, with and without inoculation of pv. , were studied. In…”
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Systematic analysis reveals cis and trans determinants affecting C-to-U RNA editing in Arabidopsis thaliana by Chu, Duan, Wei, Lai

“…C-to-U RNA editing is prevalent in the mitochondrial and chloroplast genes in plants. The biological functions of a fraction of C-to-U editing sites are…”
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N-acetylglucosamine 2-Epimerase from Pedobacter heparinus: First Experimental Evidence of a Deprotonation/Reprotonation Mechanism by Su-Yan Wang, Pedro Laborda, Ai-Min Lu, Xu-Chu Duan, Hong-Yu Ma, Li Liu, Josef Voglmeir

“…The control of cellular N-acetylmannosamine (ManNAc) levels has been postulated to be an effective way to modulate the decoration of cell surfaces with sialic…”
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Discovery and Biochemical Characterization of a Thermostable Glucose-1-phosphate Nucleotidyltransferase from Thermodesulfatator indicus by Li, Qian, Huang, Ying-Ying, Conway, Louis Patrick, He, Meng, Wei, Shuang, Huang, Kun, Duan, Xu-Chu, Flitsch, Sabine L, Voglmeir, Josef

“…The biosynthesis of NDP-glucoses is based on the nucleotide transfer from NTP donor substrates to glucose-1-phosphates catalyzed by glucose-1-phosphate…”
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A case of 9p deletion syndrome with congenital infantile glaucoma,effective method of diagnosis,and treatment by Jia, Xu, Liu, Xu-Yang, Duan, Xuan-Chu

“…Dear Editor, I am Dr.Jia X from the Department of Ophthalmology,Second Xiangya Hospital,Central South University,Changsha,China.I write to present a rare case…”
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Reduced C-to-U RNA editing rates might play a regulatory role in stress response of Arabidopsis by Chu, Duan, Wei, Lai

“…C-to-U RNA editing is prevalent in the mitochondrial and chloroplast genes in plants. The C-to-U editing rates are constantly very high. During genome…”
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