Search Results - "Chu, Colin"

Risk Factors and Incidence of Macular Edema after Cataract Surgery: A Database Study of 81984 Eyes by Chu, Colin J, Johnston, Robert L, Buscombe, Charlotte, Sallam, Ahmed B, Mohamed, Queresh, Yang, Yit C

“…To define the incidence of pseudophakic macular edema (PME) after cataract surgery and to identify contributory risk factors. Retrospective database study of…”
Get full text

IBEX: A versatile multiplex optical imaging approach for deep phenotyping and spatial analysis of cells in complex tissues by Radtke, Andrea J, Kandov, Evelyn, Lowekamp, Bradley, Speranza, Emily, Chu, Colin J, Gola, Anita, Thakur, Nishant, Shih, Rochelle, Yao, Li, Yaniv, Ziv Rafael, Beuschel, Rebecca T, Kabat, Juraj, Croteau, Joshua, Davis, Jeremy, Hernandez, Jonathan M, Germain, Ronald N

“…The diverse composition of mammalian tissues poses challenges for understanding the cell-cell interactions required for organ homeostasis and how spatial…”
Get full text

Label-free imaging of immune cell dynamics in the living retina using adaptive optics by Joseph, Aby, Chu, Colin J, Feng, Guanping, Dholakia, Kosha, Schallek, Jesse

“…Our recent work characterized the movement of single blood cells within the retinal vasculature (Joseph et al. 2019) using adaptive optics ophthalmoscopy…”
Get full text

Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina by Gonzalez-Cordero, Anai, West, Emma L, Pearson, Rachael A, Duran, Yanai, Carvalho, Livia S, Chu, Colin J, Naeem, Arifa, Blackford, Samuel J I, Georgiadis, Anastasios, Lakowski, Jorn, Hubank, Mike, Smith, Alexander J, Bainbridge, James W B, Sowden, Jane C, Ali, Robin R

“…Optic cup-like structures generated from mouse ES cells produce photoreceptor precursors that integrate and mature in vivo in three models of retinal…”
Get full text

Gene Therapy for Glaucoma by Ciliary Body Aquaporin 1 Disruption Using CRISPR-Cas9 by Wu, Jiahui, Bell, Oliver H., Copland, David A., Young, Alison, Pooley, John R., Maswood, Ryea, Evans, Rachel S., Khaw, Peng Tee, Ali, Robin R., Dick, Andrew D., Chu, Colin J.

“…Glaucoma is a common cause of blindness, yet current therapeutic options are imperfect. Clinical trials have invariably shown that reduction in intraocular…”
Get full text

IBEX: an iterative immunolabeling and chemical bleaching method for high-content imaging of diverse tissues by Radtke, Andrea J., Chu, Colin J., Yaniv, Ziv, Yao, Li, Marr, James, Beuschel, Rebecca T., Ichise, Hiroshi, Gola, Anita, Kabat, Juraj, Lowekamp, Bradley, Speranza, Emily, Croteau, Joshua, Thakur, Nishant, Jonigk, Danny, Davis, Jeremy L., Hernandez, Jonathan M., Germain, Ronald N.

“…High-content imaging is needed to catalog the variety of cellular phenotypes and multicellular ecosystems present in metazoan tissues. We recently developed…”
Get full text

In Vivo Visualization of Intravascular Patrolling Immune Cells in the Primate Eye by Ashbery, Drew, Baez, Hector C, Kanarr, Rye E, Kunala, Karteek, Power, Derek, Chu, Colin J, Schallek, Jesse, McGregor, Juliette E

“…Insight into the immune status of the living eye is essential as we seek to understand ocular disease and develop new treatments. The nonhuman primate (NHP) is…”
Get full text

Cataract surgery in uveitis: a multicentre database study by Chu, Colin J, Dick, Andrew D, Johnston, Robert L, Yang, Yit C, Denniston, Alastair K

“…Cataract is an important source of visual loss in patients with uveitis. Whether or not outcomes of cataract surgery in eyes with uveitis are worse compared…”
Get more information

A Database Study of Visual Outcomes and Intraoperative Complications of Postvitrectomy Cataract Surgery by Soliman, Mohamed Kamel, Hardin, Joshua S., Jawed, Fayez, Uwaydat, Sami H., Faramawi, Mohammed F., Chu, Colin J., Yang, Yit C., Sallam, Ahmed B.

“…To analyze the visual outcomes and rate of intraoperative complications of phacoemulsification surgery after prior pars plana vitrectomy (PPV). Retrospective,…”
Get full text

Gene Therapy of Dominant CRX-Leber Congenital Amaurosis using Patient Stem Cell-Derived Retinal Organoids by Kruczek, Kamil, Qu, Zepeng, Gentry, James, Fadl, Benjamin R., Gieser, Linn, Hiriyanna, Suja, Batz, Zachary, Samant, Mugdha, Samanta, Ananya, Chu, Colin J., Campello, Laura, Brooks, Brian P., Wu, Zhijian, Swaroop, Anand

“…Mutations in the photoreceptor transcription factor gene cone-rod homeobox (CRX) lead to distinct retinopathy phenotypes, including early-onset vision…”
Get full text

Intravenous indocyanine green dye is insufficient for robust immune cell labelling in the human retina by Bell, Oliver H, Carreño, Ester, Williams, Emily L, Wu, Jiahui, Copland, David A, Bora, Monalisa, Kobayter, Lina, Fruttiger, Marcus, Sim, Dawn A, Lee, Richard W J, Dick, Andrew D, Chu, Colin J

“…It is not currently possible to reliably visualise and track immune cells in the human central nervous system or eye. Previous work demonstrated that…”
Get full text

Assessment and in vivo scoring of murine experimental autoimmune uveoretinitis using optical coherence tomography by Chu, Colin J, Herrmann, Philipp, Carvalho, Livia S, Liyanage, Sidath E, Bainbridge, James W B, Ali, Robin R, Dick, Andrew D, Luhmann, Ulrich F O

“…Despite advances in clinical imaging and grading our understanding of retinal immune responses and their morphological correlates in experimental autoimmune…”
Get full text

Iterative Bleaching Extends Multiplexity (IBEX) facilitates simultaneous identification of all major retinal cell types by Kothurkar, Aanandita A., Patient, Gregory S., Noel, Nicole C. L., Krzywańska, Aleksandra M., Carr, Brittany J., Chu, Colin J., MacDonald, Ryan B.

“…To understand the multicellular composition of tissues, and how it is altered during development, ageing and/or disease, we must visualise the complete…”
Get full text

Reduced Macular Vessel Density and Capillary Perfusion in Glaucoma Detected Using OCT Angiography by Wu, Jiahui, Sebastian, Rani T., Chu, Colin J., McGregor, Freia, Dick, Andrew D., Liu, Lei

“…Aims: To evaluate retinal vasculature changes in primary open-angle glaucoma (POAG) and whether the functional visual loss correlates with parameters obtained…”
Get full text

Adeno-associated virus gene therapy prevents progression of kidney disease in genetic models of nephrotic syndrome by Ding, Wen Y, Kuzmuk, Valeryia, Hunter, Sarah, Lay, Abigail, Hayes, Bryony, Beesley, Matthew, Rollason, Ruth, Hurcombe, Jennifer A, Barrington, Fern, Masson, Catrin, Cathery, William, May, Carl, Tuffin, Jack, Roberts, Timothy, Mollet, Geraldine, Chu, Colin J, McIntosh, Jenny, Coward, Richard J, Antignac, Corinne, Nathwani, Amit, Welsh, Gavin I, Saleem, Moin A

“…Gene therapy for kidney diseases has proven challenging. Adeno-associated virus (AAV) is used as a vector for gene therapy targeting other organs, with…”
Get more information

Optogenetic therapy restores retinal activity in primate for at least a year following photoreceptor ablation by McGregor, Juliette E., Kunala, Karteek, Xu, Zhengyang, Murphy, Peter J., Godat, Tyler, Strazzeri, Jennifer M., Bateman, Brittany A., Fischer, William S., Parkins, Keith, Chu, Colin J., Puthussery, Teresa, Williams, David R., Merigan, William H.

“…All retina-based vision restoration approaches rely on the assumption that photoreceptor loss does not preclude reactivation of the remaining retinal…”
Get full text

Intraoperative Complications and Visual Outcomes of Cataract Surgery in Diabetes Mellitus: A Multicenter Database Study by Chancellor, John, Soliman, Mohamed K., Shoults, Catherine C., Faramawi, Mohammed F., Al-Hindi, Hytham, Kirkland, Kyle, Chu, Colin J., Yang, Yit C., Sallam, Ahmed B.

“…To compare the visual outcome and the rate of intraoperative complications in eyes of diabetic and nondiabetic patients undergoing phacoemulsification over 15…”
Get full text

Understanding immunity in a tissue‐centric context: Combining novel imaging methods and mathematics to extract new insights into function and dysfunction by Germain, Ronald N., Radtke, Andrea J., Thakur, Nishant, Schrom, Edward C., Hor, Jyh Liang, Ichise, Hiroshi, Arroyo‐Mejias, Armando J., Chu, Colin J., Grant, Spencer

“…A central question in immunology is what features allow the immune system to respond in a timely manner to a variety of pathogens encountered at unanticipated…”
Get full text

Triazole-derivatized near-infrared cyanine dyes enable local functional fluorescent imaging of ocular inflammation by Thomas, Chloe N., Alfahad, Nada, Capewell, Nicholas, Cowley, Jamie, Hickman, Eleanor, Fernandez, Antonio, Harrison, Neale, Qureshi, Omar S., Bennett, Naomi, Barnes, Nicholas M., Dick, Andrew D., Chu, Colin J., Liu, Xiaoxuan, Denniston, Alastair K., Vendrell, Marc, Hill, Lisa J.

“…Near-infrared (NIR) chemical fluorophores are promising tools for in-vivo imaging in real time but often succumb to rapid photodegradation. Indocyanine green…”
Get full text

Use of intravenous iron therapy in colorectal cancer patient with iron deficiency anemia: a propensity-score matched study by Kam, Philip Ming-Ho, Chu, Colin Wai-Ho, Chan, Emily Mei-Yi, Liu, On-Lai, Kwok, Kam-Hung

“…Purpose Iron deficiency anemia is common in colorectal cancer patients and is related to poor surgical outcome. Increasing evidence supports preoperative use…”
Get full text