Search Results - "Chu, Aurea"

Chemically Sumoylated Histone H4 Stimulates Intranucleosomal Demethylation by the LSD1–CoREST Complex by Dhall, Abhinav, Weller, Caroline E, Chu, Aurea, Shelton, Patrick M. M, Chatterjee, Champak

“…Lysine-specific demethylase 1 (LSD1) downregulates eukaryotic gene activity by demethylating mono- and dimethylated Lys4 in histone H3. Elucidating the…”
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Coordination and Substitution of DNA Polymerases in Response to Genomic Obstacles by Trakselis, Michael A, Cranford, Matthew T, Chu, Aurea M

“…The ability for DNA polymerases (Pols) to overcome a variety of obstacles in its path to maintain genomic stability during replication is a complex endeavor…”
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Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidases by Woods, Ryan D, O'Shea, Valerie L, Chu, Aurea, Cao, Sheng, Richards, Jody L, Horvath, Martin P, David, Sheila S

“…MutY adenine glycosylases prevent DNA mutations by excising adenine from promutagenic 8-oxo-7,8-dihydroguanine (OG):A mismatches. Here, we describe structural…”
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Characterization of a coupled DNA replication and translesion synthesis polymerase supraholoenzyme from archaea by Cranford, Matthew T, Chu, Aurea M, Baguley, Joshua K, Bauer, Robert J, Trakselis, Michael A

“…The ability of the replisome to seamlessly coordinate both high fidelity and translesion DNA synthesis requires a means to regulate recruitment and binding of…”
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Profiling base excision repair glycosylases with synthesized transition state analogs by Chu, Aurea M., Fettinger, James C., David, Sheila S.

“…Two base excision repair glycosylase (BER) transition state (TS) mimics, (3R,4R)-1-benzyl (hydroxymethyl) pyrrolidin-3-ol (1NBn) and (3R,4R)-(hydroxymethyl)…”
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Multisubunit Multiactive Site DNA Polymerase Complexes with Coordinated Activities by Trakselis, Michael A., Cranford, Matthew, Chu, Aurea M.

“…Duplication of the genome requires efficient, rapid, and coordinated activities of many enzymes that interact within a larger replisome complex. However,…”
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Mechanism and evolution of the DNA repair enzyme MutY by Horvath, Martin P., Drage, Evan P., Dart, Emily, Russelburg, Peyton, O'Shea, Valerie L., Woods, Ryan D., Chu, Aurea, Cao, Sheng, Richards, Jody L., David, Sheila S.

“…Abstract only…”
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Synthesis and Characterization of Azaribose Transition State Analogs of Base Excision Repair Glycosylases by Chu, Aurea Miranda

“…Oxidative damage to the DNA is one important contributor to mutagenesis and carcinogenesis. Of the four bases, guanine is the most easily oxidized leading to a…”
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