Impact of comorbid allergic diseases on health‐related quality of life of Hong Kong schoolchildren

Background Studies on the relationship between childhood allergic disease and health‐related quality of life (HRQOL) have mostly been confined to a single allergic condition. Therefore, a composite allergic score (CAS) was derived to assess the accumulated effect of eczema, asthma, and allergic rhin...

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Published in:	Pediatric allergy and immunology Vol. 34; no. 5; pp. e13953 - n/a
Main Authors:	Ng, Christina Sum Yi, Chan, Celia Hoi Yan, Fung, Yat Lui, Chau, Priscilla Sin Ying, Luk, David Chi Kong, Cheng, James Wesley Ching Hei, Tsang, Yuk Ping, Lam, Ying Yin, Chu, Ashleigh Ka Ying
Format:	Journal Article
Language:	English
Published:	England Wiley Subscription Services, Inc 01-05-2023
Subjects:	Allergic diseases Allergic rhinitis allergic score Asthma Asthma - complications Asthma - epidemiology Child childhood allergic diseases Children comorbid allergic diseases Comorbidity Disease Eczema Eczema - epidemiology Female Hay fever health‐related quality of life Hong Kong - epidemiology Humans ISAAC Prevalence Quality of Life Rhinitis Rhinitis, Allergic - complications Rhinitis, Allergic - epidemiology schoolchildren Surveys and Questionnaires Hong Kong Hong Kong China China schoolchildren allergic score ISAAC health-related quality of life comorbid allergic diseases childhood allergic diseases
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Summary:	Background Studies on the relationship between childhood allergic disease and health‐related quality of life (HRQOL) have mostly been confined to a single allergic condition. Therefore, a composite allergic score (CAS) was derived to assess the accumulated effect of eczema, asthma, and allergic rhinitis on HRQOL in Hong Kong schoolchildren. Methods Parents of grade one/two or grade eight/nine schoolchildren completed a questionnaire assessing the prevalence and severity of eczema (POEM), asthma (C‐ACT/ACT), and allergic rhinitis (VAS) and schoolchildren's HRQOL (PedsQL). Three rounds of recruitment were conducted. A total of 19 primary and 25 secondary schools agreed to participate. Results Data from 1140 caregivers of grade one/two schoolchildren and 1048 grade eight/nine schoolchildren were imputed and analyzed. The proportion of female respondents were lower in grade one/two (37.7%) but higher in grade eight/nine (57.3%). 63.8% of grade one/two and 58.1% of grade eight/nine schoolchildren reported having at least one allergic disease. In general, greater disease severity was significantly associated with lower HRQOL. After controlling for age, gender, and allergic comorbidity in hierarchical regressions, CAS significantly predicted all HRQOL outcomes in both grade one/two and grade eight/nine schoolchildren. Female grade eight/nine schoolchildren reported lower HRQOL outcomes. Conclusion Composite allergic score may be a practical tool to evaluate allergic comorbidity and the effectiveness of treatments targeting common pathological mechanisms of allergic diseases. Non‐pharmaceutical approaches should be considered, especially for patients with more than one allergic disease and greater severity.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0905-6157 1399-3038
DOI:	10.1111/pai.13953