Search Results - "Chrusciel, R. A."

Design and Synthesis of a CD4 β-Turn Mimetic that Inhibits Human Immunodeficiency Virus Envelope Glycoprotein gp120 Binding and Infection of Human Lymphocytes by Chen, Shaoxing, Chrusciel, R. Alan, Nakanishi, Hiroshi, Raktabutr, Apichaya, Johnson, Michael E., Sato, Alice, Weiner, David, Hoxie, Jim, Saragovi, Horacio Uri, Greene, Mark I., Kahn, Michael

“…Poor bioavailability, rapid degradation, antigenicity, and high cost often limit the use of proteinaceous pharmaceuticals. One goal of structural biochemistry…”
Get full text

Loops and Secondary Structure Mimetics: Development and Applications in Basic Science and Rational Drug Design by Saragovi, H. Uri, Greene, Mark I, Chrusciel, R. A, Kahn, Michael

“…One goal of protein design and structural biochemistry is the reduction of complex molecules to small functional units that are amenable to high resolution…”
Get full text

Non-peptidic HIV protease inhibitors by Chrusciel, R Alan, Strohbach, Joseph W

“…The past decade has seen many exciting achievements and advances in the treatment of HIV infection. One of the key components in this ever-evolving remedial…”
Get more information

Peptide Mimetics of the Thrombin-Bound Structure of Fibrinopeptide A by Nakanishi, Hiroshi, Chrusciel, R. Alan, Shen, Richard, Bertenshaw, Stephen, Johnson, Michael E., Rydel, Timothy J., Tulinsky, Alexander, Kahn, Michael

“…Recent work has suggested that the thrombin-bound conformation of fibrinopeptide A exhibits a strand-turn-strand motif, with a β-turn centered at residues…”
Get full text

The structure of a designed peptidomimetic inhibitor complex of alpha-thrombin by Wu, T P, Yee, V, Tulinsky, A, Chrusciel, R A, Nakanishi, H, Shen, R, Priebe, C, Kahn, M

“…Thrombin displays remarkable specificity, effecting the removal of fibrinopeptides A and B of fibrinogen through the selective cleavage of two Arg-Gly bonds…”
Get more information

Asymmetric Syntheses and Absolute Stereochemistry of 5,6-Dihydro-α-pyrones, A New Class of Potent HIV Protease Inhibitors by Judge, T. M., Phillips, G., Morris, J. K., Lovasz, K. D., Romines, K. R., Luke, G. P., Tulinsky, J., Tustin, J. M., Chrusciel, R. A., Dolak, L. A., Mizsak, S. A., Watt, W., Morris, J., Vander Velde, S. L., Strohbach, J. W., Gammill, R. B.

Get full text

Design, synthesis and conformational analysis of gamma-turn peptide mimetics of bradykinin by Sato, M, Lee, J Y, Nakanishi, H, Johnson, M E, Chrusciel, R A, Kahn, M

“…Gamma-turns are regular secondary structure elements, found with some frequency in small peptides, that have been implicated in the biologically active…”
Get more information

Examination of HIV-1 protease secondary structure specificity using conformationally constrained inhibitors by Kahn, Michael, Nakanishi, Hiroshi, Chrusciel, R. Alan, Fitzpatrick, Dennis, Johnson, Michael E

Get full text

Structure-Based Design of HIV Protease Inhibitors:  Sulfonamide-Containing 5,6-Dihydro-4-hydroxy-2-pyrones as Non-Peptidic Inhibitors by Thaisrivongs, Suvit, Skulnick, Harvey I, Turner, Steve R, Strohbach, Joseph W, Tommasi, Ruben A, Johnson, Paul D, Aristoff, Paul A, Judge, Thomas M, Gammill, Ronald B, Morris, Jeanette K, Romines, Karen R, Chrusciel, Robert A, Hinshaw, Roger R, Chong, Kong-Teck, Tarpley, W. Gary, Poppe, Susan M, Slade, David E, Lynn, Janet C, Horng, Miao-Miao, Tomich, Paul K, Seest, Eric P, Dolak, Lester A, Howe, W. Jeffrey, Howard, Gina M, Schwende, Francis J, Toth, Lisa N, Padbury, Guy E, Wilson, Grace J, Shiou, Lihua, Zipp, Gail L, Wilkinson, Karen F, Rush, Bob D, Ruwart, Mary J, Koeplinger, Kenneth A, Zhao, Zhiyang, Cole, Serena, Zaya, Renee M, Kakuk, Thomas J, Janakiraman, Musiri N, Watenpaugh, Keith D

Get full text

Lithiation and electrophilic substitution of 8-chlorodibenz[b,f][1,4]-oxazepine-10-tert-butylcarbamate: The preparation of novel fused heterocyclic derivatives of 8-chlorodibenzoxazepine by Li, James J., Chrusciel, R. Alan, Norton, Monica B., Reitz, David B., Hagen, Timothy J., Tsymbalov, Sofya, Hallinan, E. Ann

“…Lithiation of 8‐chlorodibenz[b,f][1,4]oxazepine‐10‐tert‐butylcarbamate (1) is described. Electrophilic substitution of the resulting N‐Boc dibenzoxazepine α‐…”
Get full text