Search Results - "Christrup, Lona L."

Genetic, pathological and physiological determinants of transdermal fentanyl pharmacokinetics in 620 cancer patients of the EPOS study by Barratt, Daniel T., Bandak, Benedikte, Klepstad, Pål, Dale, Ola, Kaasa, Stein, Christrup, Lona L., Tuke, Jonathan, Somogyi, Andrew A.

“…OBJECTIVEThis study aimed to investigate whether CYP3A4/5 genetic variants, together with clinical and patient factors, influence serum fentanyl and…”
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Association Between Human Pain-Related Genotypes and Variability in Opioid Analgesia: An Updated Review by Nielsen, Lecia M., Olesen, Anne E., Branford, Ruth, Christrup, Lona L., Sato, Hiroe, Drewes, Asbjørn M.

“…On an individual level, there is a difference in the analgesic response to a given opioid. Various factors such as gender, age, and genetic variation can…”
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Definition, diagnosis and treatment strategies for opioid-induced bowel dysfunction—Recommendations of the Nordic Working Group by Drewes, Asbjørn M, Munkholm, Pia, Simrén, Magnus, Breivik, Harald, Kongsgaard, Ulf E, Hatlebakk, Jan G, Agreus, Lars, Friedrichsen, Maria, Christrup, Lona L

“…Highlights • Opioid-induced bowel dysfunction and constipation (OIC) are underdiagnosed and undertreated. • Pain management and quality of life in chronic pain…”
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A cortical source localization analysis of resting EEG data after remifentanil infusion by Khodayari-Rostamabad, Ahmad, Graversen, Carina, Malver, Lasse P, Kurita, Geana P, Christrup, Lona L, Sjøgren, Per, Drewes, Asbjørn M

“…Highlights • Resting EEG source location signatures could be used as a biomarker of remifentanil. • EEG-derived brain source locations are reproducible and…”
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Pharmacokinetics, efficacy, and tolerability of fentanyl following intranasal versus intravenous administration in adults undergoing third-molar extraction: A randomized, double-blind, double-dummy, two-way, crossover study by Christrup, Lona L., PhD, Foster, David, PhD, Popper, Lars D., PhD, Troen, Tine, MSc, Upton, Richard, PhD

“…Abstract Objective: The aim of this study was to compare the pharmacokinetic profile, as well as the efficacy and tolerability, of IN and IV administration of…”
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Differences between opioids: pharmacological, experimental, clinical and economical perspectives by Drewes, Asbjørn M., Jensen, Rasmus D., Nielsen, Lecia M., Droney, Joanne, Christrup, Lona L., Arendt‐Nielsen, Lars, Riley, Julia, Dahan, Albert

“…Clinical studies comparing the response and side effects of various opioids have not been able to show robust differences between drugs. Hence, recommendations…”
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Population pharmacokinetic‐pharmacodynamic modelling of liquid and controlled‐release formulations of oxycodone in healthy volunteers by Ladebo, Louise, Foster, David J. R., Abuhelwa, Ahmad Y., Upton, Richard N., Kongstad, Kenneth T., Drewes, Asbjørn M., Christrup, Lona L., Olesen, Anne E.

“…Oral controlled‐release formulations are playing an ever‐increasing role in opioid therapy; however, little is known about their influence on the relationship…”
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Effect of Roux‐en‐Y gastric bypass on the pharmacokinetic‐pharmacodynamic relationships of liquid and controlled‐release formulations of oxycodone by Ladebo, Louise, Abuhelwa, Ahmad Y., Foster, David J. R., Kroustrup, Jens P., Pacyk, Grzegorz J., Kongstad, Kenneth T., Drewes, Asbjørn M., Christrup, Lona L., Olesen, Anne E.

“…The physiological changes following Roux‐en‐Y gastric bypass (RYGB) surgery may impact drug release from mechanistically different controlled‐release tablets,…”
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Association Between Genetic Polymorphisms and Pain Sensitivity in Patients with Hip Osteoarthritis by Olesen, Anne E., Nielsen, Lecia M., Feddersen, Søren, Erlenwein, Joachim, Petzke, Frank, Przemeck, Michael, Christrup, Lona L., Drewes, Asbjørn M.

“…Background Factors such as age, gender, and genetic polymorphisms may explain individual differences in pain phenotype. Genetic associations with pain…”
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Offset Analgesia and The Impact of Treatment with Oxycodone and Venlafaxine: A Placebo‐Controlled, Randomized Trial in Healthy Volunteers by Olesen, Anne E., Nissen, Thomas D., Nilsson, Matias, Lelic, Dina, Brock, Christina, Christrup, Lona L., Drewes, Asbjørn M.

“…Offset analgesia (OA) is a pain‐modulating mechanism described as a disproportionately large decrease in pain intensity evoked by a discrete decrease in…”
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Genetic Influences of OPRM1, OPRD1 and COMT on Morphine Analgesia in a Multi‐Modal, Multi‐Tissue Human Experimental Pain Model by Nielsen, Lecia M., Christrup, Lona L., Sato, Hiroe, Drewes, Asbjørn M., Olesen, Anne E.

“…Human studies on experimentally induced pain are of value to elucidate the genetic influence on morphine analgesia under controlled conditions. The aim of this…”
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Role of active metabolites in the use of opioids by Coller, Janet K, Christrup, Lona L, Somogyi, Andrew A

“…The opioid class of drugs, a large group, is mainly used for the treatment of acute and chronic persistent pain. All are eliminated from the body via…”
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Disruption of cortical connectivity during remifentanil administration is associated with cognitive impairment but not with analgesia by Khodayari-Rostamabad, Ahmad, Olesen, Søren S, Graversen, Carina, Malver, Lasse P, Kurita, Geana P, Sjøgren, Per, Christrup, Lona L, Drewes, Asbjørn M

“…The authors investigated the effect of remifentanil administration on resting electroencephalography functional connectivity and its relationship to cognitive…”
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Altered Frequency Distribution in the Electroencephalogram is Correlated to the Analgesic Effect of Remifentanil by Graversen, Carina, Malver, Lasse P., Kurita, Geana P., Staahl, Camilla, Christrup, Lona L., Sjøgren, Per, Drewes, Asbjørn M.

“…Opioids alter resting state brain oscillations by multiple and complex factors, which are still to be elucidated. To increase our knowledge, multi‐channel…”
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Neuropsychological assessment of chronic non-malignant pain patients treated in a multidisciplinary pain centre by Sjøgren, Per, Christrup, Lona L., Petersen, Morten Aa, Højsted, Jette

“…The aim of the study was to investigate the influence of pain, sedation, pain medications and socio-demographics on cognitive functioning in chronic…”
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A Model-Based Approach for Joint Analysis of Pain Intensity and Opioid Consumption in Postoperative Pain by Juul, Rasmus V, Knøsgaard, Katrine R, Olesen, Anne E, Pedersen, Katja V, Kreilgaard, Mads, Christrup, Lona L, Osther, Palle J, Drewes, Asbjørn M, Lund, Trine M

“…Joint analysis of pain intensity and opioid consumption is encouraged in trials of postoperative pain. However, previous approaches have not appropriately…”
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Differential effect of opioids in patients with chronic pancreatitis: An experimental pain study by Staahl, Camilla, Dimcevski, Georg, Due Andersen, Søren, Thorsgaard, Niels, Christrup, Lona L., Arendt-Nielsen, Lars, Mohr Drewes, Asbjørn

“…Objective. Animal experiments and clinical observations have indicated a different working profile of oxycodone compared to morphine, and it has previously…”
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Differences in Kidney Function Estimates Based on Creatinine and/or Cystatin C in Non-Traumatic Amputation Patients and Their Impact on Drug Prescribing by Aakjær, Mia, Houlind, Morten B, Treldal, Charlotte, Ankarfeldt, Mikkel Z, S Jensen, Pia, Andersen, Ove, Iversen, Esben, Christrup, Lona L, Petersen, Janne

“…Accurate kidney function estimates are necessary when prescribing renally-eliminated medications. Our objectives were to investigate how amputation affects…”
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Pharmacokinetic/Pharmacodynamic Relationships of Transdermal Buprenorphine and Fentanyl in Experimental Human Pain Models by Andresen, Trine, Upton, Richard N., Foster, David J.R., Christrup, Lona L., Arendt‐Nielsen, Lars, Drewes, Asbjørn M.

“…:  Pharmacokinetic/pharmacodynamic (PK/PD) modelling can be used to characterize the relationship between dose regimen of opioids, plasma concentration and…”
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Objective methods for the assessment of the spinal and supraspinal effects of opioids by Fischer, Iben W, Hansen, Tine M, Lelic, Dina, Brokjaer, Anne, Frøkjær, Jens, Christrup, Lona L, Olesen, Anne E

“…Highlights • Pupillometry is a sensitive measurement of opioid receptor activation in the CNS. • If more detailed information is needed on opioid activations…”
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