Search Results - "Christrup, L L"

European Pain Federation position paper on appropriate opioid use in chronic pain management by O'Brien, T., Christrup, L.L., Drewes, A.M., Fallon, M.T., Kress, H.G., McQuay, H.J., Mikus, G., Morlion, B.J., Perez‐Cajaraville, J., Pogatzki‐Zahn, E., Varrassi, G., Wells, J.C.D.

“…Poorly controlled pain is a global public health issue. The personal, familial and societal costs are immeasurable. Only a minority of European patients have…”
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Definition, diagnosis and treatment strategies for opioid-induced bowel dysfunction—Recommendations of the Nordic Working Group by Drewes, Asbjørn M, Munkholm, Pia, Simrén, Magnus, Breivik, Harald, Kongsgaard, Ulf E, Hatlebakk, Jan G, Agreus, Lars, Friedrichsen, Maria, Christrup, Lona L

“…Highlights • Opioid-induced bowel dysfunction and constipation (OIC) are underdiagnosed and undertreated. • Pain management and quality of life in chronic pain…”
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Pharmacokinetics, efficacy, and tolerability of fentanyl following intranasal versus intravenous administration in adults undergoing third-molar extraction: A randomized, double-blind, double-dummy, two-way, crossover study by Christrup, Lona L., PhD, Foster, David, PhD, Popper, Lars D., PhD, Troen, Tine, MSc, Upton, Richard, PhD

“…Abstract Objective: The aim of this study was to compare the pharmacokinetic profile, as well as the efficacy and tolerability, of IN and IV administration of…”
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Differences between opioids: pharmacological, experimental, clinical and economical perspectives by Drewes, Asbjørn M., Jensen, Rasmus D., Nielsen, Lecia M., Droney, Joanne, Christrup, Lona L., Arendt‐Nielsen, Lars, Riley, Julia, Dahan, Albert

“…Clinical studies comparing the response and side effects of various opioids have not been able to show robust differences between drugs. Hence, recommendations…”
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Morphine metabolites by CHRISTRUP, L. L.

“…Morphine is a potent opioid analgesic widely used for the treatment of acute pain and for long‐term treatment of severe pain. Morphine is a member of the…”
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Association Between Human Pain-Related Genotypes and Variability in Opioid Analgesia: An Updated Review by Nielsen, Lecia M., Olesen, Anne E., Branford, Ruth, Christrup, Lona L., Sato, Hiroe, Drewes, Asbjørn M.

“…On an individual level, there is a difference in the analgesic response to a given opioid. Various factors such as gender, age, and genetic variation can…”
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Lack of genetic association between OCT1, ABCB1, and UGT2B7 variants and morphine pharmacokinetics by Nielsen, LM, Sverrisdóttir, E, Stage, TB, Feddersen, S, Brøsen, K, Christrup, LL, Drewes, AM, Olesen, AE

“…A high inter-individual variation in the pharmacokinetics and pharmacodynamics of morphine has been observed. Genetic polymorphisms in genes encoding the…”
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Genetic, pathological and physiological determinants of transdermal fentanyl pharmacokinetics in 620 cancer patients of the EPOS study by Barratt, Daniel T., Bandak, Benedikte, Klepstad, Pål, Dale, Ola, Kaasa, Stein, Christrup, Lona L., Tuke, Jonathan, Somogyi, Andrew A.

“…OBJECTIVEThis study aimed to investigate whether CYP3A4/5 genetic variants, together with clinical and patient factors, influence serum fentanyl and…”
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Offset Analgesia and The Impact of Treatment with Oxycodone and Venlafaxine: A Placebo‐Controlled, Randomized Trial in Healthy Volunteers by Olesen, Anne E., Nissen, Thomas D., Nilsson, Matias, Lelic, Dina, Brock, Christina, Christrup, Lona L., Drewes, Asbjørn M.

“…Offset analgesia (OA) is a pain‐modulating mechanism described as a disproportionately large decrease in pain intensity evoked by a discrete decrease in…”
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Genetic Influences of OPRM1, OPRD1 and COMT on Morphine Analgesia in a Multi‐Modal, Multi‐Tissue Human Experimental Pain Model by Nielsen, Lecia M., Christrup, Lona L., Sato, Hiroe, Drewes, Asbjørn M., Olesen, Anne E.

“…Human studies on experimentally induced pain are of value to elucidate the genetic influence on morphine analgesia under controlled conditions. The aim of this…”
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Role of active metabolites in the use of opioids by Coller, Janet K, Christrup, Lona L, Somogyi, Andrew A

“…The opioid class of drugs, a large group, is mainly used for the treatment of acute and chronic persistent pain. All are eliminated from the body via…”
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Opioid analgesics as noncompetitive N-methyl- d-aspartate (NMDA) antagonists by Ebert, Bjarke, Thorkildsen, Christian, Andersen, Steen, Christrup, Lona L., Hjeds, Hans

“…Much evidence points to the involvement of N-methyl- d-aspartate (NMDA) receptors in the development and maintainance of neuropathic pain. In neuropathic pain,…”
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Renal function and symptoms/adverse effects in opioid-treated patients with cancer by Kurita, G. P., Lundström, S., Sjøgren, P., Ekholm, O., Christrup, L., Davies, A., Kaasa, S., Klepstad, P., Dale, O.

“…Background Renal impairment and the risk of toxicity caused by accumulation of opioids and/or active metabolites is an under‐investigated issue. This study…”
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A cortical source localization analysis of resting EEG data after remifentanil infusion by Khodayari-Rostamabad, Ahmad, Graversen, Carina, Malver, Lasse P, Kurita, Geana P, Christrup, Lona L, Sjøgren, Per, Drewes, Asbjørn M

“…Highlights • Resting EEG source location signatures could be used as a biomarker of remifentanil. • EEG-derived brain source locations are reproducible and…”
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Symptoms and side effects in chronic non-cancer pain: patient report vs. systematic assessment by JONSSON, T., CHRISTRUP, L. L., HØJSTED, J., VILLESEN, H. H., ALBJERG, T. H., RAVN-NIELSEN, L. V., SJØGREN, P.

“…Background: Relieving distressing symptoms and managing the side effects of analgesics are essential in order to improve quality of life and functional…”
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Neuropsychological assessment of chronic non-malignant pain patients treated in a multidisciplinary pain centre by Sjøgren, Per, Christrup, Lona L., Petersen, Morten Aa, Højsted, Jette

“…The aim of the study was to investigate the influence of pain, sedation, pain medications and socio-demographics on cognitive functioning in chronic…”
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Relationships Among Morphine Metabolism, Pain and Side Effects During Long-Term Treatment: An Update by Andersen, Gertrud, Christrup, Lona, Sjøgren, Per

“…The two metabolites of morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G), have been studied intensively in animals and humans during the…”
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The effects of morphine and methylnaltrexone on gastrointestinal pain in healthy male participants by Brokjær, A., Olesen, A. E., Christrup, L. L., Dahan, A., Drewes, A. M.

“…Background Opioid antagonists are increasingly used to abolish the gastrointestinal side effects of opioids. However, they can potentially interfere with local…”
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Objective methods for the assessment of the spinal and supraspinal effects of opioids by Fischer, Iben W, Hansen, Tine M, Lelic, Dina, Brokjaer, Anne, Frøkjær, Jens, Christrup, Lona L, Olesen, Anne E

“…Highlights • Pupillometry is a sensitive measurement of opioid receptor activation in the CNS. • If more detailed information is needed on opioid activations…”
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Cortical and spinal assessment - a comparative study using encephalography and the nociceptive withdrawal reflex by Fischer, IW, Gram, M, Hansen, TM, Brokjaer, A, Graversen, C, Malver, LP, Mørch, CD, Christrup, LL, Drewes, AM, Olesen, AE

“…Standardized objective methods to assess the analgesic effects of opioids, enable identification of underlying mechanisms of drug actions in the central…”
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