Alteration in serum leptin correlates with alterations in serum N-telopeptide of collagen type I and serum osteocalcin during the progression of osteoporosis in ovariectomized rats

The role of leptin during the progression of osteoporosis was investigated in ovariectomized rats by correlation of serum leptin levels with N-telopeptide of collagen type I (NTx) and osteocalcin levels before ovariectomy and 20, 40 and 60 days after the operation. Furthermore, peripheral quantitati...

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Bibliographic Details
Published in:	Clinical chemistry and laboratory medicine Vol. 43; no. 12; p. 1359
Main Authors:	Stavropoulou, Anastasia, Christopoulou, Gina E, Anastassopoulos, George, Panteliou, Sofia D, Lyritis, George P, Spiliotis, Bessie E, Karamanos, Nikos K, Panagiotopoulos, Elias, Lambiris, Elias
Format:	Journal Article
Language:	English
Published:	Germany 2005
Subjects:	Animals Biomarkers - blood Bone and Bones - metabolism Collagen - blood Collagen Type I - blood Female Leptin - blood Osteocalcin - blood Osteoporosis - blood Ovariectomy - adverse effects Peptides - blood Rats Time Factors Tomography, X-Ray Computed - methods
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Summary:	The role of leptin during the progression of osteoporosis was investigated in ovariectomized rats by correlation of serum leptin levels with N-telopeptide of collagen type I (NTx) and osteocalcin levels before ovariectomy and 20, 40 and 60 days after the operation. Furthermore, peripheral quantitative computed tomography was used to confirm the development of severe osteoporosis in rats on day 60. The levels of NTx and osteocalcin were significantly increased on day 20 [61.9+/-5.4 nM BCE (bone collagen equivalents) and 215.6+/-53.3 ng/mL, respectively] in comparison to those before ovariectomy (41.3+/-1.7 nM BCE and 60.4+/-10.9 ng/mL). Accordingly, leptin was significantly elevated on day 20 (3033+/-661 vs. 606+/-346 pg/mL before ovariectomy). Bone markers and leptin levels remained constant up to day 40, while a slight, but not statistically significant, decrease was noted for osteocalcin and leptin on day 60. Although leptin and bone markers did not correlate before ovariectomy (r=0.09 for NTx and r=-0.05 for osteocalcin), strong correlation was observed at all time points after ovariectomy. The data obtained suggest that the alterations in serum leptin levels during the progression of osteoporosis in ovariectomized rats follow the alterations in bone markers.
ISSN:	1434-6621
DOI:	10.1515/CCLM.2005.232