Search Results - "Christopoulos, Panagiotis F"

The role of the insulin-like growth factor-1 system in breast cancer by Christopoulos, Panagiotis F, Msaouel, Pavlos, Koutsilieris, Michael

“…IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the cognate receptor, IGF-1R, triggers a signaling cascade leading to…”
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Toll-Like Receptor Ligands and Interferon-γ Synergize for Induction of Antitumor M1 Macrophages by Müller, Elisabeth, Christopoulos, Panagiotis F, Halder, Sanjib, Lunde, Anna, Beraki, Kahsai, Speth, Martin, Øynebråten, Inger, Corthay, Alexandre

“…Tumor-associated macrophages may either promote or suppress tumor growth depending on their activation status. Interferon-γ (IFN-γ) has been identified as a…”
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Both Type I and Type II Interferons Can Activate Antitumor M1 Macrophages When Combined With TLR Stimulation by Müller, Elisabeth, Speth, Martin, Christopoulos, Panagiotis F, Lunde, Anna, Avdagic, Ajna, Øynebråten, Inger, Corthay, Alexandre

“…Triggering or enhancing antitumor activity of tumor-associated macrophages is an attractive strategy for cancer treatment. We have previously shown that the…”
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Targeting the Notch Signaling Pathway in Chronic Inflammatory Diseases by Christopoulos, Panagiotis F, Gjølberg, Torleif T, Krüger, Stig, Haraldsen, Guttorm, Andersen, Jan Terje, Sundlisæter, Eirik

“…The Notch signaling pathway regulates developmental cell-fate decisions and has recently also been linked to inflammatory diseases. Although therapies…”
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Specialized Pro-Resolving Mediators as Potential Regulators of Inflammatory Macrophage Responses in COVID-19 by Balta, Maria G, Papathanasiou, Evangelos, Christopoulos, Panagiotis F

“…The recent outbreak of SARS-CoV2 has emerged as one of the biggest pandemics of our century, with outrageous health, social and economic consequences globally…”
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The future of tumor vaccines in the post‐COVID‐19 era—Current challenges by Christopoulos, Panagiotis F.

“…The recent coronavirus (2019) outbreak has emerged as the biggest crisis of our time, reflecting outrageous human losses and unprecedented social,…”
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The Role of Macrophages in Oral Squamous Cell Carcinoma by Kalogirou, Eleni Marina, Tosios, Konstantinos I, Christopoulos, Panagiotis F

“…Oral cancer is a common malignancy worldwide, with high disease-related death rates. Oral squamous cell carcinoma (OSCC) accounts for more than 90% of oral…”
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Antibody blockade of Jagged1 attenuates choroidal neovascularization by Gjølberg, Torleif Tollefsrud, Wik, Jonas Aakre, Johannessen, Hanna, Krüger, Stig, Bassi, Nicola, Christopoulos, Panagiotis F., Bern, Malin, Foss, Stian, Petrovski, Goran, Moe, Morten C., Haraldsen, Guttorm, Fosse, Johanna Hol, Skålhegg, Bjørn Steen, Andersen, Jan Terje, Sundlisæter, Eirik

“…Antibody-based blocking of vascular endothelial growth factor (VEGF) reduces choroidal neovascularization (CNV) and retinal edema, rescuing vision in patients…”
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Fungal polysaccharides from Inonotus obliquus are agonists for Toll-like receptors and induce macrophage anti-cancer activity by Wold, Christian Winther, Christopoulos, Panagiotis F., Arias, Maykel A., Dzovor, Deborah Elikplim, Øynebråten, Inger, Corthay, Alexandre, Inngjerdingen, Kari Tvete

“…Fungal polysaccharides can exert immunomodulating activity by triggering pattern recognition receptors (PRRs) on innate immune cells such as macrophages. Here,…”
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Generation and Functional In Vitro Analysis of Semliki Forest Virus Vectors Encoding TNF-α and IFN-γ by Kurena, Baiba, Müller, Elisabeth, Christopoulos, Panagiotis F, Johnsen, Ingvild Bjellmo, Stankovic, Branislava, Øynebråten, Inger, Corthay, Alexandre, Zajakina, Anna

“…Cytokine gene delivery by viral vectors is a promising novel strategy for cancer immunotherapy. Semliki Forest virus (SFV) has many advantages as a delivery…”
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Reactive Species from Two-Signal Activated Macrophages Interfere with Their Oxygen Consumption Measurements by Christopoulos, Panagiotis F, Grigalavicius, Mantas, Corthay, Alexandre, Berg, Kristian, Theodossiou, Theodossis A

“…Metabolic modulation of macrophage activation has emerged as a promising strategy lately in immunotherapeutics. However, macrophages have a broad spectrum of…”
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Hacking macrophages to combat cancer and inflammatory diseases – Current advances and challenges by Christopoulos, Panagiotis F.

“…Recently, immunotherapy has been served as the treatment of choice for various human pathophysiologies, including inflammatory diseases and cancer. Though most…”
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Aiming for the Insulin-like Growth Factor-1 system in breast cancer therapeutics by Christopoulos, Panagiotis F., Corthay, Alexandre, Koutsilieris, Michael

“…•Despite the advances in therapeutics, metastasizing breast cancer remains incurable.•The IGF-1 signaling has been well implicated with breast cancer (BrCa)…”
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The role of estrogen receptor β in prostate cancer by Christoforou, Paraskevi, Christopoulos, Panagiotis F, Koutsilieris, Michael

“…Although androgen receptor (AR) signaling is the main molecular tool regulating growth and function of the prostate gland, estrogen receptor β (ERβ) is…”
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Clinical studies in humans targeting the various components of the IGF system show lack of efficacy in the treatment of cancer by Philippou, Anastassios, Christopoulos, Panagiotis F., Koutsilieris, Dr. Michael

“…The insulin-like growth factors (IGFs) system regulates cell growth, differentiation and energy metabolism and plays crucial role in the regulation of key…”
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The Role of the Androgen Receptor Signaling in Breast Malignancies by Christopoulos, Panagiotis F, Vlachogiannis, Nikolaos I, Vogkou, Christiana T, Koutsilieris, Michael

“…Breast cancer (BrCa) is the most common malignancy among women worldwide, and one of the leading causes of cancer-related deaths in females. Despite the…”
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Cadherin-11 as a therapeutic target in chronic, inflammatory rheumatic diseases by Sfikakis, Petros P, Vlachogiannis, Nikolaos I, Christopoulos, Panagiotis F

“…Abstract Cadherin-11 has been identified as a key regulator of synovial architecture mediating contact between Fibroblast-like Synoviocytes and organization in…”
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Pattern of IGF-1 variants' expression in human cancer cell lines using a novel q-RT-PCR approach by Christopoulos, Panagiotis F, Philippou, Anastassios, Koutsilieris, Michael

“…Although insulin-like growth factor-1 (IGF-1) is well-implicated in cancer biology, the potential roles of IGF-1 variants in different types of cancer are…”
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The COOH-terminus of the IGF-1Ec Isoform Enhances the Proliferation and Migration of Human MCF-7 Breast Cancer Cells by Christopoulos, Panagiotis F, Papageorgiou, Efstathia, Petraki, Constantina, Koutsilieris, Michael

“…The insulin-like growth factor-1 (IGF-1) signaling is well implicated in cancer biology, however the potential roles of the distinct IGF-1 isoforms in human…”
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Cadherin‐11 (CDH11) expression in the peripheral blood of patients with active Multiple Myeloma by Christopoulos, Panagiotis F., Sfikakis, Petros P., Nikolaou, Eftychia, Terpos, Evangelos, Koutsilieris, Michael, Kyrtsonis, Marie‐Christine

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