Search Results - "Christopher Vandevert"

PEG conjugates of potent α4 integrin inhibitors, maintaining sustained levels and bioactivity in vivo, following subcutaneous administration by Smith, Jenifer L., Rossiter, Kassandra I., Semko, Christopher M., Xu, Ying-Zi, Quincy, David A., Jagodzinski, Jacek, Dappen, Michael S., Konradi, Andrei W., Vandevert, Christopher, Garrido, Caroline, Mao, Wenxian, San Pablo, F. Bong, Wipke, Brian, Dofiles, Lilibeth, Wadsworth, Angie, Peterson, Eric, Lorenzana, Carlos, Simmonds, Stellanie, Messersmith, Elizabeth K., Bard, Frederique, Pleiss, Michael A., Yednock, Ted A.

“…Mitsunobu reactions were employed to link t-butyl esters of α4 integrin inhibitors at each of the termini of a three-arm, 40kDa, branched PEG. Cleavage of the…”
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Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse by Schenk, Dale, Barbour, Robin, Dunn, Whitney, Gordon, Grace, Grajeda, Henry, Guido, Teresa, Hu, Kang, Huang, Jiping, Johnson-Wood, Kelly, Khan, Karen, Kholodenko, Dora, Lee, Mike, Liao, Zhenmei, Lieberburg, Ivan, Motter, Ruth, Mutter, Linda, Soriano, Ferdie, Shopp, George, Vasquez, Nicki, Vandevert, Christopher, Walker, Shannan, Wogulis, Mark, Yednock, Ted, Games, Dora, Seubert, Peter

“…Amyloid-β peptide (Aβ) seems to have a central role in the neuropathology of Alzheimer's disease (AD). Familial forms of the disease have been linked to…”
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Orally available and efficacious α4β1/α4β7 integrin inhibitors by Xu, Ying-zi, Smith, Jenifer L., Semko, Christopher M., Rossiter, Kassandra I., Fukuda, Juri Y., Dappen, Michael S., Quincy, David A., Konradi, Andrei W., Mao, Wenxian, Welch, Brent, Dreyer, Mark L., Samant, Bhushan, Zhang, Hongbin, Lugar, Judevin, Liao, Zhenmei, Henschel, Carrol, Petersen, Eric, Vandevert, Christopher, Shoemaker, Mark, Wehner, Nancy, Mutter, Linda, Shopp, George, Krimm, Michael, Chen, Linda, Wipke, Brian, Dofiles, Lilibeth, Gallager, Ian, Sauer, John-Michael, Messersmith, Elizabeth K., Pleiss, Michael A., Bard, Frederique, Yednock, Ted A.

“…A series of potent α4β1/α4β7 integrin inhibitors is reported, including an inhibitor 12d with remarkable oral exposure and efficacy in rat models of rheumatoid…”
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Orally available and efficacious I-4I21/I-4I27 integrin inhibitors by Xu, Ying-zi, Smith, Jenifer, Semko, Christopher, Rossiter, Kassandra, Fukuda, Juri, Dappen, Michael, Quincy, David, Konradi, Andrei, Mao, Wenxian, Welch, Brent, Dreyer, Mark, Samant, Bhushan, Zhang, Hongbin, Lugar, Judevin, Liao, Zhenmei, Henschel, Carrol, Petersen, Eric, Vandevert, Christopher, Shoemaker, Mark, Wehner, Nancy, Mutter, Linda, Shopp, George, Krimm, Michael, Chen, Linda, Wipke, Brian, Dofiles, Lilibeth, Gallager, Ian, Sauer, John-Michael, Messersmith, Elizabeth, Pleiss, Michael, Bard, Frederique, Yednock, Ted

“…A series of potent I-4I21/I-4I27 integrin inhibitors is reported, including an inhibitor 12d with remarkable oral exposure and efficacy in rat models of…”
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PEG conjugates of potent I-4 integrin inhibitors, maintaining sustained levels and bioactivity in vivo, following subcutaneous administration by Smith, Jenifer, Rossiter, Kassandra, Semko, Christopher, Xu, Ying-Zi, Quincy, David, Jagodzinski, Jacek, Dappen, Michael, Konradi, Andrei, Vandevert, Christopher, Garrido, Caroline, Mao, Wenxian, Pablo, F, Wipke, Brian, Dofiles, Lilibeth, Wadsworth, Angie, Peterson, Eric, Lorenzana, Carlos, Simmonds, Stellanie, Messersmith, Elizabeth, Bard, Frederique, Pleiss, Michael, Yednock, Ted

“…Mitsunobu reactions were employed to link t-butyl esters of I-4 integrin inhibitors at each of the termini of a three-arm, 40 kDa, branched PEG. Cleavage of…”
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Discovery of a potent, orally bioavailable pyrimidine VLA-4 antagonist effective in a sheep asthma model by Semko, Christopher M., Chen, Linda, Dressen, Darren B., Dreyer, Mark L., Dunn, Whitney, Farouz, Francine S., Freedman, Stephen B., Holsztynska, Elizabeth J., Jefferies, Michael, Konradi, Andrei W., Liao, Anna, Lugar, Judevin, Mutter, Linda, Pleiss, Michael A., Quinn, Kevin P., Thompson, Thomas, Thorsett, Eugene D., Vandevert, Christopher, Xu, Ying-Zi, Yednock, Ted A.

“…A series of N-(pyrimidin-4-yl)-phenylalanine VLA-4 antagonists is described. Optimization of substituents at the 2 and 5 positions of the pyrimidine ring gave…”
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α4β1Integrin-dependent Cell Adhesion Is Regulated by a Low Affinity Receptor Pool That Is Conformationally Responsive to Ligand () by Yednock, Ted A., Cannon, Catherine, Vandevert, Christopher, Goldbach, Erich G., Shaw, Gray, Ellis, Debra K., Liaw, Chen, Fritz, Lawrence C., Tanner, Laura I.

“…α4β1 integrin (VLA-4) appears to be unique among the leukocyte integrins in that it can initiate the adhesion of circulating lymphocytes without cellular…”
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Immunization with amyloid-b attenuates Alzheimer-disease-like pathology in the PDAPP mouse by Schenk, Dale, Barbour, Robin, Dunn, Whitney, Gordon, Grace, Grajeda, Henry, Guido, Teresa, Hu, Kang, Huang, Jiping, Johnson-Wood, Kelly, Khan, Karen, Kholodenko, Dora, Lee, Mike, Liao, Zhenmei, Lieberburg, Ivan, Motter, Ruth, Mutter, Linda, Soriano, Ferdie, Shopp, George, Vasquez, Nicki, Vandevert, Christopher, Walker, Shannan, Wogulis, Mark, Yednock, Ted, Games, Dora, Seubert, Peter

“…Amyloid-b peptide (Ab) seems to have a central role in the neuropathology of Alzheimer's disease (AD). Familial forms of the disease have been linked to…”
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Integrin-dependent Cell Adhesion Is Regulated by a Low Affinity Receptor Pool That Is Conformationally Responsive to Ligand by Ted A. Yednock, Catherine Cannon, Christopher Vandevert, Erich G. Goldbach, Gray Shaw, Debra K. Ellis, Chen Liaw, Lawrence C. Fritz, Laura I. Tanner

“…α β integrin (VLA-4) appears to be unique among the leukocyte integrins in that it can initiate the adhesion of circulating lymphocytes without cellular…”
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