Search Results - "Christophe, Olivier"

Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration by Meliani, Amine, Boisgerault, Florence, Hardet, Romain, Marmier, Solenne, Collaud, Fanny, Ronzitti, Giuseppe, Leborgne, Christian, Costa Verdera, Helena, Simon Sola, Marcelo, Charles, Severine, Vignaud, Alban, van Wittenberghe, Laetitia, Manni, Giorgia, Christophe, Olivier, Fallarino, Francesca, Roy, Christopher, Michaud, Alicia, Ilyinskii, Petr, Kishimoto, Takashi Kei, Mingozzi, Federico

“…Gene therapy mediated by recombinant adeno-associated virus (AAV) vectors is a promising treatment for systemic monogenic diseases. However, vector…”
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von Willebrand factor biosynthesis, secretion, and clearance: connecting the far ends by Lenting, Peter J., Christophe, Olivier D., Denis, Cécile V.

“…To understand the placement of a certain protein in a physiological system and the pathogenesis of related disorders, it is not only of interest to determine…”
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Emicizumab, a bispecific antibody recognizing coagulation factors IX and X: how does it actually compare to factor VIII? by Lenting, Peter J., Denis, Cécile V., Christophe, Olivier D.

“…During the last decade, the development of improved and novel approaches for the treatment of hemophilia A has expanded tremendously. These approaches include…”
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What is your definition of Big Data? Researchers' understanding of the phenomenon of the decade by Favaretto, Maddalena, De Clercq, Eva, Schneble, Christophe Olivier, Elger, Bernice Simone

“…Thirty-nine interviews were performed with Swiss and American researchers involved in Big Data research in relevant fields. The interviews were analyzed using…”
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Von Willebrand factor: how unique structural adaptations support and coordinate its complex function by Lenting, Peter J, Denis, Cecile V, Christophe, Olivier D

“…Von Willebrand factor (VWF) is a multimeric protein consisting of covalently linked monomers, which share an identical domain architecture. Although involved…”
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Fitusiran reduces bleeding in factor X–deficient mice by Verhenne, Sebastien, McCluskey, Geneviève, Maynadié, Hortense, Adam, Frédéric, Casari, Caterina, Panicot-Dubois, Laurence, Crescence, Lydie, Dubois, Christophe, Denis, Cécile V., Lenting, Peter J., Christophe, Olivier D.

“…•Fitusiran is an investigational siRNA reducing antithrombin expression that is under clinical evaluation for the treatment of hemophilia.•Using inducible…”
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Design, Sizing, and Energy Management of Microgrids in Harbor Areas: A Review by Roy, Anthony, Auger, François, Olivier, Jean-Christophe, Schaeffer, Emmanuel, Auvity, Bruno

“…Energy efficiency and low-carbon energy systems are increasingly taken into account in seaports, due to climate change challenges and the evolution of…”
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Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen by Onyishi, Chinaemerem U., Desanti, Guillaume E., Wilkinson, Alex L., Lara-Reyna, Samuel, Frickel, Eva-Maria, Fejer, Gyorgy, Christophe, Olivier D., Bryant, Clare E., Mukhopadhyay, Subhankar, Gordon, Siamon, May, Robin C.

“…The opportunistic fungal pathogen Cryptococcus neoformans causes lethal infections in immunocompromised patients. Macrophages are central to the host response…”
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Differences in venous clot structures between hemophilic mice treated with emicizumab versus factor VIII or factor VIIIFc by Sefiane, Thibaud, Maynadié, Hortense, Ettingshausen, Carmen Escurola, Muczynski, Vincent, Heiligenstein, Xavier, Dumont, Julien, Christophe, Olivier D, Denis, Cécile V, Casari, Caterina, Lenting, Peter J

“…Recombinant factor VIII (rFVIII), rFVIIIFc and emicizumab are established treatment options in the management of hemophilia A. Each has its unique mode of…”
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The Cambridge Analytica affair and Internet‐mediated research by Schneble, Christophe Olivier, Elger, Bernice Simone, Shaw, David

“…Graphical Abstract The latest Facebook data breach highlights the need for guidelines for internet‐mediated big‐data research…”
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Development of a dual hybrid AAV vector for endothelial-targeted expression of von Willebrand factor by Barbon, Elena, Kawecki, Charlotte, Marmier, Solenne, Sakkal, Aboud, Collaud, Fanny, Charles, Severine, Ronzitti, Giuseppe, Casari, Caterina, Christophe, Olivier D., Denis, Cécile V., Lenting, Peter J., Mingozzi, Federico

“…Von Willebrand disease (VWD), the most common inherited bleeding disorder in humans, is caused by quantitative or qualitative defects in von Willebrand factor…”
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Macrophage scavenger receptor SR-AI contributes to the clearance of von Willebrand factor by Wohner, Nikolett, Muczynski, Vincent, Mohamadi, Amel, Legendre, Paulette, Proulle, Valérie, Aymé, Gabriel, Christophe, Olivier D, Lenting, Peter J, Denis, Cécile V, Casari, Caterina

“…Previously, we found that LDL-receptor related protein-1 on macrophages mediated shear stress-dependent clearance of von Willebrand factor. In control…”
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A combined optimization of the sizing and the energy management of an industrial multi-energy microgrid: Application to a harbour area by Roy, Anthony, Olivier, Jean-Christophe, Auger, François, Auvity, Bruno, Schaeffer, Emmanuel, Bourguet, Salvy, Schiebel, Jonathan, Perret, Jacques

“…•Sizing and operation combined optimization is proposed for an industrial microgrid.•Multi-energy microgrid is studied, with electricity and hydrogen as energy…”
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Static and Dynamic Electrical Models of Proton Exchange Membrane Electrolysers: A Comprehensive Review by Marefatjouikilevaee, Haniyeh, Auger, Francois, Olivier, Jean-Christophe

“…Proton Exchange Membrane (PEM) water electrolysers have gained attention as efficient and sustainable hydrogen production devices. Understanding their…”
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Drug Resistance in Glioblastoma: The Two Faces of Oxidative Stress by Olivier, Christophe, Oliver, Lisa, Lalier, Lisenn, Vallette, François M

“…Glioblastomas (GBM) are the most common primary brain tumor with a median survival of 15 months. A population of cells with stem cell properties (glioblastoma…”
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A Novel Single-Domain Antibody Against von Willebrand Factor A1 Domain Resolves Leukocyte Recruitment and Vascular Leakage During Inflammation—Brief Report by Aymé, Gabriel, Adam, Frédéric, Legendre, Paulette, Bazaa, Amine, Proulle, Valérie, Denis, Cécile V, Christophe, Olivier D, Lenting, Peter J

“…OBJECTIVE—von Willebrand factor (VWF) is crucial to hemostasis, but also plays a role in inflammatory processes. Unfortunately, no proper monoclonal antibodies…”
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A hemophilia A mouse model for the in vivo assessment of emicizumab function by Ferrière, Stephen, Peyron, Ivan, Christophe, Olivier D., Kawecki, Charlotte, Casari, Caterina, Muczynski, Vincent, Nathwani, Amit, Kauskot, Alexandre, Lenting, Peter J., Denis, Cécile V.

“…The bispecific antibody emicizumab is increasingly used for hemophilia A treatment. However, its specificity for human factors IX and X (FIX and FX) has…”
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Thrombin generation on vascular cells in the presence of factor VIII and/or emicizumab by Atsou, Sénadé, Schellenberg, Célia, Lagrange, Jeremy, Lacolley, Patrick, Lenting, Peter J, Denis, Cécile V, Christophe, Olivier D, Regnault, Véronique

“…The effect of factor VIII (FVIII) or emicizumab on thrombin generation is usually assessed in assays using synthetic phospholipids. Here, we assessed thrombin…”
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Reliability Evaluation of Renewable Power Systems through Distribution Network Power Outage Modelling by Kebede, Fitsum Salehu, Olivier, Jean-Christophe, Bourguet, Salvy, Machmoum, Mohamed

“…Intermittent power interruptions and blackouts with long outage durations are very common, especially on weak distribution grids such as in developing…”
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Data protection during the coronavirus crisis by Schneble, Christophe Olivier, Elger, Bernice Simone, Martin Shaw, David

“…Graphical Abstract Smartphone apps to track SARS‐CoV 2 infections need to fulfill certain minimal requirements to guarantee privacy and justify their use under…”
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