Search Results - "Christophe, M."

Native Chemical Ligation and Extended Methods: Mechanisms, Catalysis, Scope, and Limitations by Agouridas, Vangelis, El Mahdi, Ouafâa, Diemer, Vincent, Cargoët, Marine, Monbaliu, Jean-Christophe M, Melnyk, Oleg

“…The native chemical ligation reaction (NCL) involves reacting a C-terminal peptide thioester with an N-terminal cysteinyl peptide to produce a native peptide…”
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Revisiting the Paradigm of Reaction Optimization in Flow with a Priori Computational Reaction Intelligence by Bianchi, Pauline, Monbaliu, Jean‐Christophe M.

“…The use of micro/meso‐fluidic reactors has resulted in both new scenarios for chemistry and new requirements for chemists. Through flow chemistry, large‐scale…”
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Perspectives for the Upgrading of Bio‐Based Vicinal Diols within the Developing European Bioeconomy by Muzyka, Claire, Monbaliu, Jean‐Christophe M.

“…The previous decade has witnessed a drastic increase of European incentives aimed at pushing forward the transition from an exclusively petro‐based economy…”
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Incorporation of Ru(II) Polypyridyl Complexes into Nanomaterials for Cancer Therapy and Diagnosis by Soliman, Nancy, Gasser, Gilles, Thomas, Christophe M.

“…Ru(II) polypyridyl complexes are compounds of great interest in cancer therapy due to their unique photophysical, photochemical, and biological properties. For…”
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The Decision to Extubate in the Intensive Care Unit by THILLE, Arnaud W, RICHARD, Jean-Christophe M, BROCHARD, Laurent

“…The day of extubation is a critical time during an intensive care unit (ICU) stay. Extubation is usually decided after a weaning readiness test involving…”
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On Demand Flow Platform for the Generation of Anhydrous Dinitrogen Trioxide and Its Further Use in N‐Nitrosative Reactions by Chen, Yuesu, Renson, Sébastien, Monbaliu, Jean‐Christophe M.

“…Dinitrogen trioxide (N2O3) is a powerful and efficient nitrosating agent that comes with an unprecedented atom economy. However, the synthetic application of…”
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On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system by Adamo, Andrea, Beingessner, Rachel L., Behnam, Mohsen, Chen, Jie, Jamison, Timothy F., Jensen, Klavs F., Monbaliu, Jean-Christophe M., Myerson, Allan S., Revalor, Eve M., Snead, David R., Stelzer, Torsten, Weeranoppanant, Nopphon, Wong, Shin Yee, Zhang, Ping

“…Pharmaceutical manufacturing typically uses batch processing at multiple locations. Disadvantages of this approach include long production times and the…”
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Production and Polymerization of Biobased Acrylates and Analogs by Fouilloux, Hugo, Thomas, Christophe M.

“…To prepare biobased polymers, particular attention must be paid to the obtention of the monomers from which they are derived. (Meth)acrylates and their analogs…”
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Potential for Lung Recruitment Estimated by the Recruitment-to-Inflation Ratio in Acute Respiratory Distress Syndrome. A Clinical Trial by Chen, Lu, Del Sorbo, Lorenzo, Grieco, Domenico L, Junhasavasdikul, Detajin, Rittayamai, Nuttapol, Soliman, Ibrahim, Sklar, Michael C, Rauseo, Michela, Ferguson, Niall D, Fan, Eddy, Richard, Jean-Christophe M, Brochard, Laurent

“…Response to positive end-expiratory pressure (PEEP) in acute respiratory distress syndrome depends on recruitability. We propose a bedside approach to estimate…”
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Continuous Flow Organic Chemistry: Successes and Pitfalls at the Interface with Current Societal Challenges by Gérardy, Romaric, Emmanuel, Noémie, Toupy, Thomas, Kassin, Victor‐Emmanuel, Tshibalonza, Nelly Ntumba, Schmitz, Michaël, Monbaliu, Jean‐Christophe M.

“…This review intends to provide the reader with a clear and concise overview of how preparative continuous flow organic chemistry could potentially impact on…”
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Intensified Continuous Flow Process for the Scalable Production of Bio‐Based Glycerol Carbonate by Muzyka, Claire, Renson, Sébastien, Grignard, Bruno, Detrembleur, Christophe, Monbaliu, Jean‐Christophe M.

“…A subtle combination of fundamental and applied organic chemistry toward process intensification is demonstrated for the large‐scale production of bio‐based…”
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The LUTIA trial: a small step for PRRT, a giant leap for intra-arterial radionuclide therapy trial methodology by Deroose, Christophe M.

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Epidemiology of Weaning Outcome according to a New Definition. The WIND Study by Béduneau, Gaëtan, Pham, Tài, Schortgen, Frédérique, Piquilloud, Lise, Zogheib, Elie, Jonas, Maud, Grelon, Fabien, Runge, Isabelle, Nicolas Terzi, Grangé, Steven, Barberet, Guillaume, Guitard, Pierre-Gildas, Frat, Jean-Pierre, Constan, Adrien, Chretien, Jean-Marie, Mancebo, Jordi, Mercat, Alain, Richard, Jean-Christophe M, Brochard, Laurent

“…The weaning process concerns all patients receiving mechanical ventilation. A previous classification into simple, prolonged, and difficult weaning ignored…”
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Continuous Flow Organophosphorus Chemistry by Morodo, Romain, Bianchi, Pauline, Monbaliu, Jean‐Christophe M.

“…Organophosphorus derivatives are widespread compounds that chemists find from the bench to the plant, with numerous daily life applications. Besides their…”
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Will the next generation of chemical plants be in miniaturized flow reactors? by Monbaliu, Jean-Christophe M, Legros, Julien

“…For decades, a production paradigm based on centralized, stepwise, large scale processes has dominated the chemical industry horizon. While effective to meet…”
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Sonographic evaluation of the diaphragm in critically ill patients. Technique and clinical applications by Matamis, Dimitrios, Soilemezi, Eleni, Tsagourias, Matthew, Akoumianaki, Evangelia, Dimassi, Saoussen, Boroli, Filippo, Richard, Jean-Christophe M., Brochard, Laurent

“…The use of ultrasonography has become increasingly popular in the everyday management of critically ill patients. It has been demonstrated to be a safe and…”
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One-Pot Catalysis: A Privileged Approach for Sustainable Polymers? by Upitak, Kanokon, Thomas, Christophe M.

“…Conspectus Almost all aspects of daily life involve polymers in some form or the other. However, polymer production is largely based on finite feedstocks…”
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Esophageal Manometry and Regional Transpulmonary Pressure in Lung Injury by Yoshida, Takeshi, Amato, Marcelo B P, Grieco, Domenico Luca, Chen, Lu, Lima, Cristhiano A S, Roldan, Rollin, Morais, Caio C A, Gomes, Susimeire, Costa, Eduardo L V, Cardoso, Paulo F G, Charbonney, Emmanuel, Richard, Jean-Christophe M, Brochard, Laurent, Kavanagh, Brian P

“…Esophageal manometry is the clinically available method to estimate pleural pressure, thus enabling calculation of transpulmonary pressure (Pl). However, many…”
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Iodospirocyclization of Tryptamine‐Derived Isocyanides: Formal Total Synthesis of Aspidofractinine by Saya, Jordy M., Roose, Thomas R., Peek, Jarryt J., Weijers, Bram, de Waal, Thomas J. S., Vande Velde, Christophe M. L., Orru, Romano V. A., Ruijter, Eelco

“…The N‐iodosuccinimide‐mediated spirocyclization of tryptamine‐derived isocyanides to generate spiroindolenines is reported. The products contain both an imine…”
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Driving Pressure and Survival in the Acute Respiratory Distress Syndrome by Amato, Marcelo B.P, Meade, Maureen O, Slutsky, Arthur S, Brochard, Laurent, Costa, Eduardo L.V, Schoenfeld, David A, Stewart, Thomas E, Briel, Matthias, Talmor, Daniel, Mercat, Alain, Richard, Jean-Christophe M, Carvalho, Carlos R.R, Brower, Roy G

“…This analysis of previously reported trials shows that low tidal volumes, a key component of safer ventilation strategies, confer a protective effect against…”
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