Search Results - "Christofides, Anthos"

The role of peroxisome proliferator-activated receptors (PPAR) in immune responses by Christofides, Anthos, Konstantinidou, Eirini, Jani, Chinmay, Boussiotis, Vassiliki A.

“…Peroxisome proliferator-activated receptors (PPARs) are fatty acid-activated transcription factors of nuclear hormone receptor superfamily that regulate energy…”
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Targeted deletion of PD-1 in myeloid cells induces antitumor immunity by Strauss, Laura, Mahmoud, Mohamed A A, Weaver, Jessica D, Tijaro-Ovalle, Natalia M, Christofides, Anthos, Wang, Qi, Pal, Rinku, Yuan, Min, Asara, John, Patsoukis, Nikolaos, Boussiotis, Vassiliki A

“…PD-1, a T cell checkpoint receptor and target of cancer immunotherapy, is also expressed on myeloid cells. The role of myeloid-specific versus T cell-specific…”
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Epigenetic regulation of cancer biology and anti-tumor immunity by EZH2 by Christofides, Anthos, Karantanos, Theodoros, Bardhan, Kankana, Boussiotis, Vassiliki A

“…Polycomb group proteins regulate chromatin structure and have an important regulatory role on gene expression in various cell types. Two polycomb group…”
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Regulation of T Cell Differentiation and Function by EZH2 by Karantanos, Theodoros, Chistofides, Anthos, Barhdan, Kankana, Li, Lequn, Boussiotis, Vassiliki A

“…The enhancer of zeste homolog 2 (EZH2), one of the polycomb-group proteins, is the catalytic subunit of Polycomb-repressive complex 2 (PRC2) and induces the…”
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Critical Role of IL-8 Targeting in Gliomas by Kosmopoulos, Marinos, Christofides, Anthos, Drekolias, Dimitrios, Zavras, Phaedon D, Gargalionis, Antonios N, Piperi, Christina

“…Glioma is a heterogeneous, highly complicated central nervous system (CNS) tumor with uncertain mechanism of initiation and progression, resulting in an…”
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Left Atrial Evaluation in Immune Check Point Inhibitor Myocarditis Using Cardiac Magnetic Resonance Imaging and Correlations with Cardiovascular Outcomes by Jeyashanmugaraja, Gini Priyadharshini, Kwan, Jennifer, Shah, Nimish, Lamy, Jerome, Khattab, Mohamad, Chehayeb, Rachel Jaber, Guajardo, Ana Ferrigno, Lin, Derrick, Christofides, Anthos, Alkhatib, Deya, Martinez, Carlos Matute, Im, Yunju, Salem, Joe-Elie, Redheuil, Alban, Peters, Dana, Baldassarre, Lauren

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Structural, biochemical, and functional properties of the Rap1-Interacting Adaptor Molecule (RIAM) by Sari-Ak, Duygu, Torres-Gomez, Alvaro, Yazicioglu, Yavuz-Furkan, Christofides, Anthos, Patsoukis, Nikolaos, Lafuente, Esther M, Boussiotis, Vassiliki A

“…Leukocytes, the leading players of immune system, are involved in innate and adaptive immune responses. Leukocyte adhesion to endothelial cells during…”
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Osteoprotegerin expression during the micro- and macrometastatic phases of the osteoblastic metastasis in prostate cancer: therapeutic implications by Pneumaticos, Spyros G, Christofides, Anthos, Gkioka, Eliona, Kalogeropoulos, Theodoros, Msaouel, Pavlos, Koutsilieris, Michael

“…Osteoprotegerin (OPG) acts as a soluble decoy receptor for the bone marrow stroma cell-derived and osteoblast-derived receptor activator of nuclear factor-kB…”
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The complex role of tumor-infiltrating macrophages by Christofides, Anthos, Strauss, Laura, Yeo, Alan, Cao, Carol, Charest, Alain, Boussiotis, Vassiliki A.

“…Long recognized as an evolutionarily ancient cell type involved in tissue homeostasis and immune defense against pathogens, macrophages are being re-discovered…”
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Targeted Deletion of Pparβ/δ in Myeloid Cells Enhances Their Tumor-Promoting Function by Christofides, Anthos, Pal, Rinku, Patsoukis, Nikolaos, Boussiotis, Vassiliki A

“…Peroxisome proliferator activated receptors (PPARs) are transcription factors of the nuclear hormone transcription superfamily. Thee different PPAR subtypes…”
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Pathophysiological mechanisms regulated by cytokines in gliomas by Christofides, Anthos, Kosmopoulos, Marinos, Piperi, Christina

“…•Cytokine deregulation characterizes gliomas.•IL-18 links glioma formation to microglial inflammation.•TNF family members mediate tumor growth.•IL-8, IL-6 and…”
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RIAM regulates myeloid cell fate commitment and macrophage polarization and controls tumor progression by Christofides, Anthos, Cao, Carol, Pal, Rinku, Boussiotis, Vassiliki A

“…Abstract Initiation of immune responses requires integrin-mediated adhesion between T cells and APC, linking innate and adaptive immunity. Integrins also…”
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Single-cell RNA sequencing reveals evolution of immune landscape during glioblastoma progression by Yeo, Alan T., Rawal, Shruti, Delcuze, Bethany, Christofides, Anthos, Atayde, Agata, Strauss, Laura, Balaj, Leonora, Rogers, Vaughn A., Uhlmann, Erik J., Varma, Hemant, Carter, Bob S., Boussiotis, Vassiliki A., Charest, Al

“…Glioblastoma (GBM) is an incurable primary malignant brain cancer hallmarked with a substantial protumorigenic immune component. Knowledge of the GBM immune…”
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Pparβ/δ Has an Indispensable Role in T Cell Function and Anti-Tumor Responses by Ibis, Betul, Christofides, Anthos, Aliazis, Konstantinos, Shah, Rushil, Pal, Rinku, Boussiotis, Vassiliki A

“…The peroxisome proliferator-activated receptors (PPARs) are a group of transcriptional factor of the nuclear hormone receptor superfamily, which promote…”
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PD-1 Expression By Dendritic Cells Is a Key Regulator of T-Cell Immunity in Cancer by Shah, Rushil, Aliazis, Konstantinos, Christofides, Anthos, Pham, Angelique A, Pal, Rinku, Boussiotis, Vassiliki A

“…Programmed cell death 1 (PD-1) is an inhibitory receptor expressed on a variety of immune cells and a therapeutic target of checkpoint immunotherapy for cancer…”
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Specific PD-1 Deletion on Regulatory T Cells Leads to Enhanced Anti-Tumor Responses by Aliazis, Konstantinos, Christofides, Anthos, Aksoylar, Halil-Ibrahim, Shah, Rushil, Pal, Rinku, Patsoukis, Nikolaos, Boussiotis, Vassiliki A

“…Programmed cell death 1 (PD-1) is a T cell inhibitory receptor and the most extensively exploited therapeutic target of checkpoint immunotherapy in cancer…”
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Immune cellular components and signaling pathways in the tumor microenvironment by Yenyuwadee, Sasitorn, Aliazis, Konstantinos, Wang, Qi, Christofides, Anthos, Shah, Rushil, Patsoukis, Nikolaos, Boussiotis, Vassiliki A.

“…During the past decade there has been a revolution in cancer therapeutics by the emergence of antibody-based and cell-based immunotherapies that modulate…”
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42243 RIAM regulates T cell migration and activation in melanoma by Yenyuwadee, Sasitorn, Aliazis, Konstantinos, Christofides, Anthos, Aksoylar, Halil-Ibrahim, Pal, Rinku, Boussiotis, Vassiliki A.

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Loss of the Nuclear Receptor Pparγ Primes T Effector (TEFF) Differentiation of Antigen-Specific CD8+ T Cells by Shah, Rushil, Katopodi, Xanthi-Leda, Christofides, Anthos, Pal, Rinku, Vlachos, Ioannis, Patsoukis, Nikolaos, Boussiotis, Vassiliki A

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Loss of the nuclear receptor PPARγ primes CD8+ T cells for exhaustion by Shah, Rushil, Christofides, Anthos, Aksoylar, Halil-Ibrahim, Pal, Rinku, Boussiotis, Vassiliki A, Patsoukis, Nikolaos

“…Abstract Peroxisome proliferator activated receptors (PPARs) are transcription factors that belong to nuclear hormone superfamily, with three distinct types…”
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