Search Results - "Christodoulides, M"

Pattern recognition receptors in microbial keratitis by Taube, M-A, del Mar Cendra, M, Elsahn, A, Christodoulides, M, Hossain, P

“…Microbial keratitis is a significant cause of global visual impairment and blindness. Corneal infection can be caused by a wide variety of pathogens, each of…”
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Distribution of carried pneumococcal clones in UK children following the introduction of the 7-valent pneumococcal conjugate vaccine: A 3-year cross-sectional population based analysis by Tocheva, Anna S, Jefferies, Johanna M.C, Christodoulides, M, Faust, Saul N, Clarke, Stuart C

“…Highlights • PCV-7 related pneumococcal clones decreased in paediatric carriage after vaccine implementation. • PCV-7 implementation coincided with the…”
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Effective plasmid DNA and small interfering RNA delivery to diseased human brain microvascular endothelial cells by Slanina, H, Schmutzler, M, Christodoulides, M, Kim, K S, Schubert-Unkmeir, A

“…Expression of exogenous DNA or small interfering RNA (siRNA) in vitro is significantly affected by the particular delivery system utilized. In this study, we…”
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Cytokine Response to Staphylococcus aureus (SA) in Human Lung, Skin and Nasal Tissue by Lowings, K.M, Christodoulides, M, Warner, J.A

“…Human lung (HL) tissue was obtained from patients (n = 21) undergoing lung resection, human skin (HS) from patients undergoing mastectomy (n = 32) and human…”
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Identification of novel pneumolysin alleles from paediatric carriage isolates of Streptococcus pneumoniae by JEFFERIES, J. M. C, TOCHEVA, A. S, RUBERY, H, BENNETT, J, GARLAND, J, CHRISTODOULIDES, M, FAUST, S. N, SMITH, A, MITCHELL, T. J, CLARKE, S. C

“…Pneumolysin (Ply) is a major virulence factor of Streptococcus pneumoniae and is produced by all known clinical isolates of pneumococci. Pneumolysin toxoids…”
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Immunization with Recombinant Opc Outer Membrane Protein from Neisseria meningitidis: Influence of Sequence Variation and Levels of Expression on the Bactericidal Immune Response against Meningococci by JOLLEY, Keith A, APPLEBY, Lynn, WRIGHT, J. Claire, CHRISTODOULIDES, Myron, HECKELS, John E

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Dynamics of Carriage of Neisseria meningitidis in a Group of Military Recruits: Subtype Stability and Specificity of the Immune Response following Colonization by Jones, G. R., Christodoulides, M., Brooks, J. L., Miller, A. R. O., Cartwright, K. A. V., Heckels, J. E.

“…Meningococcal carriage and the immune response to colonization were studied in a group of military recruits undergoing basic training. Subtyping by…”
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Interactions of Neisseria gonorrhoeae with Mature Human Macrophage Opacity Proteins Influence Production of Proinflammatory Cytokines by MAKEPEACE, Benjamin L, WATT, Peter J, HECKELS, John E, CHRISTODOULIDES, Myron

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Immunization with a multiple antigen peptide containing defined B- and T-cell epitopes: production of bactericidal antibodies against group B Neisseria meningitidis by Christodoulides, Myron, Heckels, John E

“…Molecular Microbiology, University of Southampton, Southampton General Hospital, Tremona Rd, Southampton, SO18 6YD, UK Author for correspondence: Myron…”
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Coadministration of the cyanobacterial lipopolysaccharide antagonist CyP with antibiotic inhibits cytokine production by an in vitro meningitis model infected with Neisseria meningitidis by OLIVER, Rebecca, STAPLES, Karl J, HECKELS, John, ROSSETTI, Carlo, MOLTENI, Monica, CHRISTODOULIDES, Myron

“…In this study, the objective was to determine the anti-inflammatory properties of CyP, a cyanobacterial lipopolysaccharide (LPS) antagonist, used in…”
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Immunization with recombinant Chaperonin60 (Chp60) outer membrane protein induces a bactericidal antibody response against Neisseria meningitidis by Phillips, Renee, Williams, Jeannette N, Tan, Wei-Ming, Bielecka, Magdalena K, Thompson, Hannah, Hung, Miao-Chiu, Heckels, John E, Christodoulides, Myron

“…Highlights • Neisseria meningtidis Chaperonin60 (Chp60) protein induces serum bactericidal antibodies. • Chp60 protein shows minimal amino acid sequence…”
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Pertussis vaccines: present status by Christodoulides, M

“…The eradication of pertussis as a worldwide disease is unforeseeable for the present and immediate future. Mortality and morbidity from clinical pertussis are…”
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The potency of tissue-type plasminogen activator (TPA) determined with chromogen and clot-lysis assays by Christodoulides, M, Boucher, D W

“…An assessment was made of two methods for determining the potency of tissue-type plasminogen activator (TPA). A chromogenic microtitre plate assay was…”
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Immunization with the Recombinant PorB Outer Membrane Protein Induces a Bactericidal Immune Response against Neisseria meningitidis by WRIGHT, J. Claire, WILLIAMS, Jeannette N, CHRISTODOULIDES, Myron, HECKELS, John E

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Acellular pertussis vaccine prepared by a simple extraction and toxoiding procedure by Christodoulides, M, Sidey, F M, Parton, R, Stewart-Tull, D E

“…An extract containing predominantly pertussis toxin (PT) and filamentous haemagglutinin (FHa) was obtained from culture supernates of Bordetella pertussis by a…”
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Activation of human meningeal cells is modulated by lipopolysaccharide (LPS) and non‐LPS components of Neisseria meningitidis and is independent of Toll‐like receptor (TLR)4 and TLR2 signalling by Humphries, Holly E., Triantafilou, Martha, Makepeace, Benjamin L., Heckels, John E., Triantafilou, Kathy, Christodoulides, Myron

“…Summary The interactions of Neisseria meningitidis with cells of the meninges are critical to progression of the acute, compartmentalized intracranial…”
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Multivalent liposome-based vaccines containing different serosubtypes of PorA protein induce cross-protective bactericidal immune responses against Neisseria meningitidis by Humphries, Holly E., Williams, Jeannette N., Blackstone, Ramona, Jolley, Keith A., Yuen, Ho M., Christodoulides, Myron, Heckels, John E.

“…Four serosubtypes (P1.7, 16, P1.7-2, 4, P1.19, 15 and P1.5-1, 10-4) of the PorA outer-membrane protein of Neisseria meningitidis were purified as recombinant…”
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Development of Immunity to Serogroup B Meningococci during Carriage of Neisseria meningitidis in a Cohort of University Students by JORDENS, J. Zoe, WILLIAMS, Jeannette N, JONES, Graeme R, CHRISTODOULIDES, Myron, HECKELS, John E

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Different meningitis‐causing bacteria induce distinct inflammatory responses on interaction with cells of the human meninges by Fowler, Mark I., Weller, Roy O., Heckels, John E., Christodoulides, Myron

“…Summary The interactions of bacterial pathogens with cells of the human leptomeninges are critical events in the progression of meningitis. An in vitro model…”
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Expression of Proinflammatory Cytokines and Receptors by Human Fallopian Tubes in Organ Culture following Challenge with Neisseria gonorrhoeae by MAISEY, Kevin, NARDOCCI, Gino, IMARAI, Monica, CARDENAS, Hugo, RIOS, Miguel, CROXATTO, Horacio B, HECKELS, John E, CHRISTODOULIDES, Myron, VELASQUEZ, Luis A

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