Search Results - "Christinger, Hans W"

The Crystal Structure of Placental Growth Factor in Complex with Domain 2 of Vascular Endothelial Growth Factor Receptor-1 by Christinger, Hans W., Fuh, Germaine, de Vos, Abraham M., Wiesmann, Christian

“…Placental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family and plays an important role in pathological angiogenic…”
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Vascular Endothelial Growth Factor: Crystal Structure and Functional Mapping of the Kinase Domain Receptor Binding Site by Muller, Yves A., Li, Bing, Christinger, Hans W., Wells, James A., Cunningham, Brian C., De Vos, Abraham M.

“…Vascular endothelial growth factor (VEGF) is a homodimeric member of the cystine knot family of growth factors, with limited sequence homology to…”
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VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 å resolution and mutational analysis of the interface by Muller, Yves A, Chen, Yvonne, Christinger, Hans W, Li, Bing, Cunningham, Brian C, Lowman, Henry B, de Vos, Abraham M

“…Background: Vascular endothelial growth factor (VEGF) is a highly specific angiogenic growth factor; anti-angiogenic treatment through inhibition of receptor…”
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The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 Å resolution: multiple copy flexibility and receptor binding by Muller, Yves A, Christinger, Hans W, Keyt, Bruce A, de Vos, Abraham M

“…Background: Vascular endothelial growth factor (VEGF) is an endothelial cell-specific angiogenic and vasculogenic mitogen. VEGF also plays a role in pathogenic…”
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Solution structure of the heparin-binding domain of vascular endothelial growth factor by Fairbrother, Wayne J, Champe, Mark A, Christinger, Hans W, Keyt, Bruce A, Starovasnik, Melissa A

“…Background: Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen and is a potent angiogenic and vascular permeabilizing factor…”
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Triggering Cell Death: The Crystal Structure of Apo2L/TRAIL in a Complex with Death Receptor 5 by Hymowitz, Sarah G, Christinger, Hans W, Fuh, Germaine, Ultsch, Mark, O'Connell, Mark, Kelley, Robert F, Ashkenazi, Avi, de Vos, Abraham M

“…Formation of a complex between Apo2L (also called TRAIL) and its signaling receptors, DR4 and DR5, triggers apoptosis by inducing the oligomerization of…”
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Novel Peptides Selected to Bind Vascular Endothelial Growth Factor Target the Receptor-Binding Site by Fairbrother, Wayne J, Christinger, Hans W, Cochran, Andrea G, Fuh, Germaine, Keenan, Christopher J, Quan, Clifford, Shriver, Stephanie K, Tom, Jeffrey Y. K, Wells, James A, Cunningham, Brian C

“…Peptides that inhibit binding of vascular endothelial growth factor (VEGF) to its receptors, KDR and Flt-1, have been produced using phage display. Libraries…”
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Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor by Kossiakoff, Anthony A, Elkins, Patricia A, Christinger, Hans W, Sandowski, Yael, Sakal, Edna, Gertler, Arieh, de Vos, Abraham M

“…The structure of the ternary complex between ovine placental lactogen (oPL) and the extracellular domain (ECD) of the rat prolactin receptor (rPRLR) reveals…”
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Crystal Structure of the Complex between VEGF and a Receptor-Blocking Peptide by Wiesmann, Christian, Christinger, Hans W, Cochran, Andrea G, Cunningham, Brian C, Fairbrother, Wayne J, Keenan, Christopher J, Meng, Gloria, de Vos, Abraham M

“…Vascular endothelial growth factor (VEGF) is a specific and potent angiogenic factor and, therefore, a prime therapeutic target for the development of…”
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1H, 13C, and 15N backbone assignment and secondary structure of the receptor‐binding domain of vascular endothelial growth factor by Fairbrother, Wayne J., Champe, Mark A., Christinger, Hans W., Keyt, Bruce A., Starovasnik, Melissa A.

“…Nearly complete sequence‐specific 1H, 13C, and 15N resonance assignments are reported for the backbone atoms of the receptor‐binding domain of vascular…”
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Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen by Chen, Y, Wiesmann, C, Fuh, G, Li, B, Christinger, H W, McKay, P, de Vos, A M, Lowman, H B

“…The Fab portion of a humanized antibody (Fab-12; IgG form known as rhuMAb VEGF) to vascular endothelial growth factor (VEGF) has been affinity-matured through…”
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Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states by Starovasnik, M A, Christinger, H W, Wiesmann, C, Champe, M A, de Vos, A M, Skelton, N J

“…The extracellular portion of the VEGF and PlGF receptor, Flt-1 (or VEGFR-1), consists of seven immunoglobulin-like domains. The second domain from the N…”
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Crystallization of the receptor binding domain of vascular endothelial growth factor by Christinger, Hans W., Muller, Yves A., Berleau, Lea T., Keyt, Bruce A., Cunningham, Brian C., Ferrara, Napoleone, de Vos, Abraham M.

“…Vascular endothelial growth factor (VEGF) is a potent angiogenic factor with a unique specificity for vascular endothelial cells. In addition to its role in…”
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Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured fab in complex with antigen 1 1Edited by I. A. Wilson by Chen, Yvonne, Wiesmann, Christian, Fuh, Germaine, Li, Bing, Christinger, Hans W, McKay, Patrick, de Vos, Abraham M, Lowman, Henry B

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Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states 1 1Edited by P. E. Wright by Starovasnik, Melissa A., Christinger, Hans W., Wiesmann, Christian, Champe, Mark A., de Vos, Abraham M., Skelton, Nicholas J.

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Triggering Cell Death by Hymowitz, Sarah G, Christinger, Hans W, Fuh, Germaine, Ultsch, Mark, O'Connell, Mark, Kelley, Robert F, Ashkenazi, Avi, de Vos, Abraham M

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1 H, 13 C, and 15 N backbone assignment and secondary structure of the receptor‐binding domain of vascular endothelial growth factor by Fairbrother, Wayne J., Champe, Mark A., Christinger, Hans W., Keyt, Bruce A., Starovasnik, Melissa A.

“…Nearly complete sequence‐specific 1 H, 13 C, and 15 N resonance assignments are reported for the backbone atoms of the receptor‐binding domain of vascular…”
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Crystal Structure at 1.7 Å Resolution of VEGF in Complex with Domain 2 of the Flt-1 Receptor by Wiesmann, Christian, Fuh, Germaine, Christinger, Hans W., Eigenbrot, Charles, Wells, James A., de Vos, Abraham M.

“…Vascular endothelial growth factor (VEGF) is a homodimeric hormone that induces proliferation of endothelial cells through binding to the kinase domain…”
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Crystallization of ovine placental lactogen in a 1:2 complex with the extracellular domain of the rat prolactin receptor by Christinger, Hans W., Elkins, Patricia A., Sandowski, Yael, Sakal, Edna, Gertler, Arieh, Kossiakoff, Anthony A., De Vos, Abraham M.

“…Growth hormone and prolactin control somato‐lactogenic biology. While high‐resolution crystal structures have been determined for receptor complexes of human…”
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