Search Results - "Christine Blancher"

TET2 Drives 5hmc Marking of GATA6 and Epigenetically Defines Pancreatic Ductal Adenocarcinoma Transcriptional Subtypes by Eyres, Michael, Lanfredini, Simone, Xu, Haonan, Burns, Adam, Blake, Andrew, Willenbrock, Frances, Goldin, Robert, Hughes, Daniel, Hughes, Sophie, Thapa, Asmita, Vavoulis, Dimitris, Hubert, Aline, D’Costa, Zenobia, Sabbagh, Ahmad, Abraham, Aswin G., Blancher, Christine, Jones, Stephanie, Verrill, Clare, Silva, Michael, Soonawalla, Zahir, Maughan, Timothy, Schuh, Anna, Mukherjee, Somnath, O’Neill, Eric

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by advanced disease stage at presentation, aggressive disease biology, and resistance to therapy,…”
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MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU by Favaro, Elena, Ramachandran, Anassuya, McCormick, Robert, Gee, Harriet, Blancher, Christine, Crosby, Meredith, Devlin, Cecilia, Blick, Christopher, Buffa, Francesca, Li, Ji-Liang, Vojnovic, Borivoj, Pires das Neves, Ricardo, Glazer, Peter, Iborra, Francisco, Ivan, Mircea, Ragoussis, Jiannis, Harris, Adrian L

“…Hypoxia in cancers results in the upregulation of hypoxia inducible factor 1 (HIF-1) and a microRNA, hsa-miR-210 (miR-210) which is associated with a poor…”
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Metabolic Profiling Reveals a Contribution of Gut Microbiota to Fatty Liver Phenotype in Insulin-Resistant Mice by Dumas, Marc-Emmanuel, Barton, Richard H., Toye, Ayo, Cloarec, Olivier, Blancher, Christine, Rothwell, Alice, Fearnside, Jane, Tatoud, Roger, Blanc, Véronique, Lindon, John C., Mitchell, Steve C., Holmes, Elaine, McCarthy, Mark I., Scott, James, Gauguier, Dominique, Nicholson, Jeremy K.

“…Here, we study the intricate relationship between gut microbiota and host cometabolic phenotypes associated with dietary-induced impaired glucose homeostasis…”
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Microbial-Host Co-metabolites Are Prodromal Markers Predicting Phenotypic Heterogeneity in Behavior, Obesity, and Impaired Glucose Tolerance by Dumas, Marc-Emmanuel, Rothwell, Alice R., Hoyles, Lesley, Aranias, Thomas, Chilloux, Julien, Calderari, Sophie, Noll, Elisa M., Péan, Noémie, Boulangé, Claire L., Blancher, Christine, Barton, Richard H., Gu, Quan, Fearnside, Jane F., Deshayes, Chloé, Hue, Christophe, Scott, James, Nicholson, Jeremy K., Gauguier, Dominique

“…The influence of the gut microbiome on metabolic and behavioral traits is widely accepted, though the microbiome-derived metabolites involved remain unclear…”
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Genome-wide copy number variation analysis in extended families and unrelated individuals characterized for musical aptitude and creativity in music by Ukkola-Vuoti, Liisa, Kanduri, Chakravarthi, Oikkonen, Jaana, Buck, Gemma, Blancher, Christine, Raijas, Pirre, Karma, Kai, Lähdesmäki, Harri, Järvelä, Irma

“…Music perception and practice represent complex cognitive functions of the human brain. Recently, evidence for the molecular genetic background of music…”
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Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models by Nicholson, Jeremy K, Wallis, Robert H, Baunsgaard, Dorrit, Sidelmann, Ulla Grove, Keun, Hector C, Gauguier, Dominique, Barton, Richard H, D'Amato, Lisa, Dumas, Marc-Emmanuel, Blancher, Christine, Wilder, Steven P, Argoud, Karène, Bihoreau, Marie-Thérèse, Fearnside, Jane F, Scott, James

“…Characterizing the relationships between genomic and phenotypic variation is essential to understanding disease etiology. Information-dense data sets derived…”
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Phylometabonomic patterns of adaptation to high fat diet feeding in inbred mice by Fearnside, Jane F, Dumas, Marc-Emmanuel, Rothwell, Alice R, Wilder, Steven P, Cloarec, Olivier, Toye, Ayo, Blancher, Christine, Holmes, Elaine, Tatoud, Roger, Barton, Richard H, Scott, James, Nicholson, Jeremy K, Gauguier, Dominique

“…Insulin resistance plays a central role in type 2 diabetes and obesity, which develop as a consequence of genetic and environmental factors. Dietary changes…”
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The genome-wide landscape of copy number variations in the MUSGEN study provides evidence for a founder effect in the isolated Finnish population by Kanduri, Chakravarthi, Ukkola-Vuoti, Liisa, Oikkonen, Jaana, Buck, Gemma, Blancher, Christine, Raijas, Pirre, Karma, Kai, Lähdesmäki, Harri, Järvelä, Irma

“…Here we characterized the genome-wide architecture of copy number variations (CNVs) in 286 healthy, unrelated Finnish individuals belonging to the MUSGEN…”
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Functional annotations of diabetes nephropathy susceptibility loci through analysis of genome-wide renal gene expression in rat models of diabetes mellitus by Hu, Yaomin, Kaisaki, Pamela J, Argoud, Karène, Wilder, Steven P, Wallace, Karin J, Woon, Peng Y, Blancher, Christine, Tarnow, Lise, Groop, Per-Henrik, Hadjadj, Samy, Marre, Michel, Parving, Hans-Henrik, Farrall, Martin, Cox, Roger D, Lathrop, Mark, Vionnet, Nathalie, Bihoreau, Marie-Thérèse, Gauguier, Dominique

“…Hyperglycaemia in diabetes mellitus (DM) alters gene expression regulation in various organs and contributes to long term vascular and renal complications. We…”
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Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts by Mole, David R., Blancher, Christine, Copley, Richard R., Pollard, Patrick J., Gleadle, Jonathan M., Ragoussis, Jiannis, Ratcliffe, Peter J.

“…Hypoxia-inducible factor (HIF) controls an extensive range of adaptive responses to hypoxia. To better understand this transcriptional cascade we performed…”
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Association of ARNT Splice Variants with Estrogen Receptor-negative Breast Cancer, Poor Induction of Vascular Endothelial Growth Factor under Hypoxia, and Poor Prognosis by CHUNHUA QIN, WILSON, Cody, BLANCHER, Christine, TAYLOR, Marian, SAFE, Stephen, HARRIS, Adrian L

“…The aryl hydrocarbon receptor nuclear translocator (ARNT) is a basic helix-loop-helix transcription factor that forms heterodimers with the aryl hydrocarbon…”
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Statistical Total Correlation Spectroscopy:  An Exploratory Approach for Latent Biomarker Identification from Metabolic 1H NMR Data Sets by Cloarec, Olivier, Dumas, Marc-Emmanuel, Craig, Andrew, Barton, Richard H, Trygg, Johan, Hudson, Jane, Blancher, Christine, Gauguier, Dominique, Lindon, John C, Holmes, Elaine, Nicholson, Jeremy

“…We describe here the implementation of the statistical total correlation spectroscopy (STOCSY) analysis method for aiding the identification of potential…”
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Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk by Orr, Nick, Lemnrau, Alina, Cooke, Rosie, Fletcher, Olivia, Tomczyk, Katarzyna, Jones, Michael, Johnson, Nichola, Lord, Christopher J, Mitsopoulos, Costas, Zvelebil, Marketa, McDade, Simon S, Buck, Gemma, Blancher, Christine, Trainer, Alison H, James, Paul A, Bojesen, Stig E, Bokmand, Susanne, Nevanlinna, Heli, Mattson, Johanna, Friedman, Eitan, Laitman, Yael, Palli, Domenico, Masala, Giovanna, Zanna, Ines, Ottini, Laura, Giannini, Giuseppe, Hollestelle, Antoinette, Ouweland, Ans M W van den, Novaković, Srdjan, Krajc, Mateja, Gago-Dominguez, Manuela, Castelao, Jose Esteban, Olsson, Håkan, Hedenfalk, Ingrid, Easton, Douglas F, Pharoah, Paul D P, Dunning, Alison M, Bishop, D Timothy, Neuhausen, Susan L, Steele, Linda, Houlston, Richard S, Garcia-Closas, Montserrat, Ashworth, Alan, Swerdlow, Anthony J

“…Nick Orr and colleagues report a genome-wide association study for male breast cancer. They identify a new susceptibility locus at RAD51B and examine…”
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The landscape of copy number variations in Finnish families with autism spectrum disorders by Kanduri, Chakravarthi, Kantojärvi, Katri, Salo, Paula M, Vanhala, Raija, Buck, Gemma, Blancher, Christine, Lähdesmäki, Harri, Järvelä, Irma

“…Rare de novo and inherited copy number variations (CNVs) have been implicated in autism spectrum disorder (ASD) risk. However, the genetic underpinnings of ASD…”
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Effects of ras and von Hippel-Lindau (VHL) Gene Mutations on Hypoxia-inducible Factor (HIF)-1 alpha , HIF-2 alpha , and Vascular Endothelial Growth Factor Expression and Their Regulation by the Phosphatidylinositol 3'-Kinase/Akt Signaling Pathway by Blancher, C, Moore, J W, Robertson, N, Harris, AL

“…Many oncogenes induce expression of vascular endothelial growth factor (VEGF), a key factor in tumor angiogenesis. Phosphatidylinositol 3'-kinase (PI3K)/Akt is…”
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Nectinepsin: A New Extracellular Matrix Protein of the Pexin Family by Blancher, Christine, Omri, Boubaker, Bidou, Laure, Pessac, Bernard, Crisanti, Patricia

“…We report the isolation and characterization of a novel cDNA from quail neuroretina encoding a putative protein named nectinepsin. The nectinepsin cDNA…”
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Sodium dodecyl sulphate-polyacrylamide denaturing gel electrophoresis and Western blotting techniques by Blancher, Christine, Cormick, Rob Mc

“…The study of proteins, their expression and post-translational modification, is a key process in molecular biology. Immunoblotting is a well-established and…”
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The landscape of copy number variations in F innish families with autism spectrum disorders by Kanduri, Chakravarthi, Kantojärvi, Katri, Salo, Paula M, Vanhala, Raija, Buck, Gemma, Blancher, Christine, Lähdesmäki, Harri, Järvelä, Irma

“…Rare de novo and inherited copy number variations (CNVs) have been implicated in autism spectrum disorder (ASD) risk. However, the genetic underpinnings of ASD…”
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Relationship of hypoxia-inducible factor (HIF)-1α and HIF-2α expression to vascular endothelial growth factor induction and hypoxia survival in human breast cancer cell lines by BLANCHER, Christine, MOORE, John W, TALKS, Kate L, HOULBROOK, Sue, HARRIS, Adrian L

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The Transfection of Rabbit Articular Chondrocytes Is Independent of Their Differentiation State by Say Viengchareun, Sophie Thenet-Gauci, Nathalie Steimberg, Christine Blancher, Crisanti, Patricia, Monique Adolphe

“…The ability to introduce exogenous genes into mammalian cells has become a powerful tool to study the regulation of gene expression and to obtain established…”
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