Search Results - "Christina F. Spiropoulou"

Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase by Jordan, Paul C, Liu, Cheng, Raynaud, Pauline, Lo, Michael K, Spiropoulou, Christina F, Symons, Julian A, Beigelman, Leo, Deval, Jerome

“…Paramyxoviruses represent a family of RNA viruses causing significant human diseases. These include measles virus, the most infectious virus ever reported, in…”
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Crimean-Congo hemorrhagic fever and expansion from endemic regions by Spengler, Jessica R, Bergeron, Éric, Spiropoulou, Christina F

“…Crimean-Congo hemorrhagic fever (CCHF) is a virus-mediated hemorrhagic disease that occurs over a wide geographic region. In recent years, a variety of active…”
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GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses by Lo, Michael K., Jordan, Robert, Arvey, Aaron, Sudhamsu, Jawahar, Shrivastava-Ranjan, Punya, Hotard, Anne L., Flint, Mike, McMullan, Laura K., Siegel, Dustin, Clarke, Michael O., Mackman, Richard L., Hui, Hon C., Perron, Michel, Ray, Adrian S., Cihlar, Tomas, Nichol, Stuart T., Spiropoulou, Christina F.

“…GS-5734 is a monophosphate prodrug of an adenosine nucleoside analog that showed therapeutic efficacy in a non-human primate model of Ebola virus infection. It…”
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Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination by Ellebedy, Ali H, Jackson, Katherine J L, Kissick, Haydn T, Nakaya, Helder I, Davis, Carl W, Roskin, Krishna M, McElroy, Anita K, Oshansky, Christine M, Elbein, Rivka, Thomas, Shine, Lyon, George M, Spiropoulou, Christina F, Mehta, Aneesh K, Thomas, Paul G, Boyd, Scott D, Ahmed, Rafi

“…Immunologic memory promotes faster and more-efficient responses after re-exposure to pathogens. Ahmed and colleagues characterize a subset of human B cells…”
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Human Ebola virus infection results in substantial immune activation by McElroy, Anita K., Akondy, Rama S., Davis, Carl W., Ellebedy, Ali H., Mehta, Aneesh K., Kraft, Colleen S., Lyon, G. Marshall, Ribner, Bruce S., Varkey, Jay, Sidney, John, Sette, Alessandro, Campbell, Shelley, Ströher, Ute, Damon, Inger, Nichol, Stuart T., Spiropoulou, Christina F., Ahmed, Rafi

“…Significance In 2014, Ebola virus became a household term. The ongoing outbreak in West Africa is the largest Ebola virus outbreak ever recorded, with over…”
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Recovery of Recombinant Crimean Congo Hemorrhagic Fever Virus Reveals a Function for Non-structural Glycoproteins Cleavage by Furin by Bergeron, Éric, Zivcec, Marko, Chakrabarti, Ayan K, Nichol, Stuart T, Albariño, César G, Spiropoulou, Christina F

“…Crimean Congo hemorrhagic fever virus (CCHFV) is a negative-strand RNA virus of the family Bunyaviridae (genus: Nairovirus). In humans, CCHFV causes fever,…”
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In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses by Lo, Michael K., Shi, Pei-Yong, Chen, Yen-Liang, Flint, Mike, Spiropoulou, Christina F.

“…There are currently no antiviral therapies available for the tick-borne flaviviruses associated with hemorrhagic fevers: Kyasanur Forest disease virus (KFDV),…”
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Identification of 2′-deoxy-2′-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus by Welch, Stephen R., Scholte, Florine E.M., Flint, Mike, Chatterjee, Payel, Nichol, Stuart T., Bergeron, Éric, Spiropoulou, Christina F.

“…Crimean-Congo hemorrhagic fever virus (CCHFV), a tick-borne orthonairovirus, causes a severe hemorrhagic disease in humans (Crimean-Congo hemorrhagic fever,…”
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Statins Suppress Ebola Virus Infectivity by Interfering with Glycoprotein Processing by Shrivastava-Ranjan, Punya, Flint, Mike, Bergeron, Éric, McElroy, Anita K, Chatterjee, Payel, Albariño, César G, Nichol, Stuart T, Spiropoulou, Christina F

“…Ebola virus (EBOV) infection is a major public health concern due to high fatality rates and limited effective treatments. Statins, widely used…”
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Biomarker correlates of survival in pediatric patients with Ebola virus disease by McElroy, Anita K, Erickson, Bobbie R, Flietstra, Timothy D, Rollin, Pierre E, Nichol, Stuart T, Towner, Jonathan S, Spiropoulou, Christina F

“…Outbreaks of Ebola virus disease (EVD) occur sporadically in Africa and are associated with high case-fatality rates. Historically, children have been less…”
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Andes Virus Disrupts the Endothelial Cell Barrier by Induction of Vascular Endothelial Growth Factor and Downregulation of VE-Cadherin by SHRIVASTAVA-RANJAN, Punya, ROLLIN, Pierre E, SPIROPOULOU, Christina F

“…OA  Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+…”
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Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus by Zivcec, Marko, Scholte, Florine E M, Spiropoulou, Christina F, Spengler, Jessica R, Bergeron, Éric

“…Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen that causes high morbidity and mortality. Efficacy of vaccines and antivirals to treat…”
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Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses by Choe, Hyeryun, Radoshitzky, Sheli R, Abraham, Jonathan, Spiropoulou, Christina F, Kuhn, Jens H, Nguyen, Dan, Li, Wenhui, Nagel, Jane, Schmidt, Paul J, Nunberg, Jack H, Andrews, Nancy C, Farzan, Michael

“…At least five arenaviruses cause viral haemorrhagic fevers in humans. Lassa virus, an Old World arenavirus, uses the cellular receptor -dystroglycan to infect…”
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Identification of broadly neutralizing monoclonal antibodies against Crimean-Congo hemorrhagic fever virus by Zivcec, Marko, Guerrero, Lisa I.W., Albariño, César G., Bergeron, Éric, Nichol, Stuart T., Spiropoulou, Christina F.

“…Despite the serious public health impact of Crimean-Congo hemorrhagic fever (CCHF), the efficacy of antivirals targeting the causative agent, CCHF virus…”
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A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus by Flint, Mike, Chatterjee, Payel, Lin, David L., McMullan, Laura K., Shrivastava-Ranjan, Punya, Bergeron, Éric, Lo, Michael K., Welch, Stephen R., Nichol, Stuart T., Tai, Andrew W., Spiropoulou, Christina F.

“…There are no approved therapies for Ebola virus infection. Here, to find potential therapeutic targets, we perform a screen for genes essential for Ebola virus…”
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Structural characterization of protective non-neutralizing antibodies targeting Crimean-Congo hemorrhagic fever virus by Durie, Ian A., Tehrani, Zahra R., Karaaslan, Elif, Sorvillo, Teresa E., McGuire, Jack, Golden, Joseph W., Welch, Stephen R., Kainulainen, Markus H., Harmon, Jessica R., Mousa, Jarrod J., Gonzalez, David, Enos, Suzanne, Koksal, Iftihar, Yilmaz, Gurdal, Karakoc, Hanife Nur, Hamidi, Sanaz, Albay, Cansu, Spengler, Jessica R., Spiropoulou, Christina F., Garrison, Aura R., Sajadi, Mohammad M., Bergeron, Éric, Pegan, Scott D.

“…Crimean-Congo Hemorrhagic Fever Virus (CCHFV) causes a life-threatening disease with up to a 40% mortality rate. With no approved medical countermeasures,…”
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Crimean-Congo Hemorrhagic Fever Virus Suppresses Innate Immune Responses via a Ubiquitin and ISG15 Specific Protease by Scholte, Florine E.M., Zivcec, Marko, Dzimianski, John V., Deaton, Michelle K., Spengler, Jessica R., Welch, Stephen R., Nichol, Stuart T., Pegan, Scott D., Spiropoulou, Christina F., Bergeron, Éric

“…Antiviral responses are regulated by conjugation of ubiquitin (Ub) and interferon-stimulated gene 15 (ISG15) to proteins. Certain classes of viruses encode Ub-…”
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Macrophage Activation Marker Soluble CD163 Associated with Fatal and Severe Ebola Virus Disease in Humans by McElroy, Anita K, Shrivastava-Ranjan, Punya, Harmon, Jessica R, Martines, Roosecelis B, Silva-Flannery, Luciana, Flietstra, Timothy D, Kraft, Colleen S, Mehta, Aneesh K, Lyon, G. Marshall, Varkey, Jay B, Ribner, Bruce S, Nichol, Stuart T, Zaki, Sherif R, Spiropoulou, Christina F

“…Ebola virus disease (EVD) is associated with elevated cytokine levels, and hypercytokinemia is more pronounced in fatal cases. This type of hyperinflammatory…”
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25-Hydroxycholesterol Inhibition of Lassa Virus Infection through Aberrant GP1 Glycosylation by Shrivastava-Ranjan, Punya, Bergeron, Éric, Chakrabarti, Ayan K, Albariño, César G, Flint, Mike, Nichol, Stuart T, Spiropoulou, Christina F

“…Lassa virus (LASV) infection is a major public health concern due to high fatality rates and limited effective treatment. The interferon-stimulated gene…”
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Humanized Mouse Model of Ebola Virus Disease Mimics the Immune Responses in Human Disease by Bird, Brian H., Spengler, Jessica R., Chakrabarti, Ayan K., Khristova, Marina L., Sealy, Tara K., Coleman-McCray, JoAnn D., Martin, Brock E., Dodd, Kimberly A., Goldsmith, Cynthia S., Sanders, Jeanine, Zaki, Sherif R., Nichol, Stuart T., Spiropoulou, Christina F.

“…Animal models recapitulating human Ebola virus disease (EVD) are critical for insights into virus pathogenesis. Ebola virus (EBOV) isolates derived directly…”
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