Search Results - "Christina, V."

Learning the language of DNA by Theodoris, Christina V.

“…A genomic foundation model broadly enables sequence modeling, prediction, and design With a vocabulary of just four nucleotides, the language of DNA encodes…”
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Supporting students' meaningful engagement in scientific modeling through epistemological messages: A case study of contrasting teaching approaches by Ke, Li, Schwarz, Christina V.

“…Teachers' instructional practices are critical for guiding students' engagement in scientific practices within the classroom knowledge building community. In…”
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A Work in Progress: Diversity, Equity, and Inclusion Challenges and Opportunities Within Veterinary Medicine by Tran, Christina V

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Development of an autonomous and bifunctional quorum-sensing circuit for metabolic flux control in engineered Escherichia coli by Dinh, Christina V., Prather, Kristala L. J.

“…Metabolic engineering seeks to reprogram microbial cells to efficiently and sustainably produce value-added compounds. Since chemical production can be at odds…”
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Human Disease Modeling Reveals Integrated Transcriptional and Epigenetic Mechanisms of NOTCH1 Haploinsufficiency by Theodoris, Christina V., Li, Molong, White, Mark P., Liu, Lei, He, Daniel, Pollard, Katherine S., Bruneau, Benoit G., Srivastava, Deepak

“…The mechanisms by which transcription factor haploinsufficiency alters the epigenetic and transcriptional landscape in human cells to cause disease are…”
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Facilitation of sensorimotor temporal recalibration mechanisms by cerebellar tDCS in patients with schizophrenia spectrum disorders and healthy individuals by Schmitter, Christina V., Straube, Benjamin

“…Core symptoms in patients with schizophrenia spectrum disorders (SSD), like hallucinations or ego-disturbances, have been associated with a failure of internal…”
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Efficient and accurate binding free energy calculation of Aβ 9-40 protofilament propagation by Frost, Christina V, Schwierz, Nadine, Zacharias, Martin

“…Self-assembled aggregation of peptides and proteins into regular amyloid fibrils is associated with several neurodegenerative diseases. In case of Alzheimer's…”
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Efficient and accurate binding free energy calculation of Aβ9-40 protofilament propagation by Frost, Christina V, Schwierz, Nadine, Zacharias, Martin

“…Self-assembled aggregation of peptides and proteins into regular amyloid fibrils is associated with several neurodegenerative diseases. In case of Alzheimer's…”
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Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes by Grarup, Niels, Moltke, Ida, Andersen, Mette K., Dalby, Maria, Vitting-Seerup, Kristoffer, Kern, Timo, Mahendran, Yuvaraj, Jørsboe, Emil, Larsen, Christina V. L., Dahl-Petersen, Inger K., Gilly, Arthur, Suveges, Daniel, Dedoussis, George, Zeggini, Eleftheria, Pedersen, Oluf, Andersson, Robin, Bjerregaard, Peter, Jørgensen, Marit E., Albrechtsen, Anders, Hansen, Torben

“…We have identified a variant in ADCY3 (encoding adenylate cyclase 3) associated with markedly increased risk of obesity and type 2 diabetes in the Greenlandic…”
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From monomer to fibril: Abeta‐amyloid binding to Aducanumab antibody studied by molecular dynamics simulation by Frost, Christina V., Zacharias, Martin

“…Alzheimer's disease is one of the most common causes of dementia. It is believed that the aggregation of short Aβ‐peptides to form oligomeric and…”
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Identifying Essential Epistemic Heuristics for Guiding Mechanistic Reasoning in Science Learning by Krist, Christina, Schwarz, Christina V., Reiser, Brian J.

“…Mechanistic reasoning, or reasoning systematically through underlying factors and relationships that give rise to phenomena, is a powerful thinking strategy…”
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Epistemologies in practice: Making scientific practices meaningful for students by Berland, Leema K., Schwarz, Christina V., Krist, Christina, Kenyon, Lisa, Lo, Abraham S., Reiser, Brian J.

“…Recent research and policy documents call for engaging students and teachers in scientific practices such that the goal of science education shifts from…”
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Dynamics of Seeded Aβ40-Fibril Growth from Atomistic Molecular Dynamics Simulations: Kinetic Trapping and Reduced Water Mobility in the Locking Step by Schwierz, Nadine, Frost, Christina V, Geissler, Phillip L, Zacharias, Martin

“…Filamentous β-amyloid aggregates are crucial for the pathology of Alzheimer’s disease. Despite the tremendous biomedical importance, the molecular pathway of…”
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Memory CD8+ T cell responses to cancer by Han, Jichang, Khatwani, Nikhil, Searles, Tyler G., Turk, Mary Jo, Angeles, Christina V.

“…•Memory CD8+ T cell subsets mediate long-lived anti-tumor immunity.•Stem-like memory T cells infiltrate tumors and are capable of self-renewal.•TRM cells are…”
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Transfer learning enables predictions in network biology by Theodoris, Christina V., Xiao, Ling, Chopra, Anant, Chaffin, Mark D., Al Sayed, Zeina R., Hill, Matthew C., Mantineo, Helene, Brydon, Elizabeth M., Zeng, Zexian, Liu, X. Shirley, Ellinor, Patrick T.

“…Mapping gene networks requires large amounts of transcriptomic data to learn the connections between genes, which impedes discoveries in settings with limited…”
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The impact of cerebellar transcranial direct current stimulation (tDCS) on sensorimotor and inter-sensory temporal recalibration by Schmitter, Christina V., Straube, Benjamin

“…The characteristic temporal relationship between actions and their sensory outcomes allows us to distinguish self- from externally generated sensory events…”
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Predicting tensile properties of Ti-6Al-4V produced via directed energy deposition by Hayes, Brian J., Martin, Brian W., Welk, Brian, Kuhr, Samuel J., Ales, Thomas K., Brice, David A., Ghamarian, Iman, Baker, Andrew H., Haden, Christina V., Harlow, D. Gary, Fraser, Hamish L., Collins, Peter C.

“…Advanced manufacturing approaches, including additive manufacturing (i.e., “3D printing”) of metallic structures requires a change to qualification strategies…”
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Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease by Theodoris, Christina V, Zhou, Ping, Liu, Lei, Zhang, Yu, Nishino, Tomohiro, Huang, Yu, Kostina, Aleksandra, Ranade, Sanjeev S, Gifford, Casey A, Uspenskiy, Vladimir, Malashicheva, Anna, Ding, Sheng, Srivastava, Deepak

“…Mapping the gene-regulatory networks dysregulated in human disease would allow the design of network-correcting therapies that treat the core disease…”
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Beyond assessing knowledge about models and modeling: Moving toward expansive, meaningful, and equitable modeling practice by Schwarz, Christina V., Ke, Li, Salgado, Michelle, Manz, Eve

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Majorana edge States in atomic wires coupled by pair hopping by Kraus, Christina V, Dalmonte, Marcello, Baranov, Mikhail A, Läuchli, Andreas M, Zoller, P

“…We present evidence for Majorana edge states in a number conserving theory describing a system of spinless fermions on two wires that are coupled by pair…”
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