Search Results - "Christina, Szabo M"

Assessment of higher order structure comparability in therapeutic proteins using nuclear magnetic resonance spectroscopy by Amezcua, Carlos A, Szabo, Christina M

“…In this work, we applied nuclear magnetic resonance (NMR) spectroscopy to rapidly assess higher order structure (HOS) comparability in protein samples. Using a…”
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Structure-activity relationship of the pro- and anticoagulant effects of Fucus vesiculosus fucoidan by Zhang, Z, Till, S, Jiang, C, Knappe, S, Reutterer, S, Scheiflinger, F, Szabo, C M, Dockal, M

“…Fucoidan is a highly complex sulfated polysaccharide commonly extracted from brown seaweed. In addition to their many biological activities, fucoidans have…”
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A comparison of quantitative nuclear magnetic resonance methods: internal, external, and electronic referencing by Cullen, Christopher H., Ray, G. Joseph, Szabo, Christina M.

“…The performance of three quantitative NMR methods was compared in terms of short‐term and long‐term precision and accuracy, robustness, linear range, and…”
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Complete Monosaccharide Analysis by High-Performance Anion-Exchange Chromatography with Pulsed Amperometric Detection by Zhang, Zhenqing, Khan, Nazeer M, Nunez, Karen M, Chess, Edward K, Szabo, Christina M

“…Monosaccharide analysis is a critical way to profile the composition of complex carbohydrates. Methods to analyze neutral and amino sugars have been…”
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Inhibition of Geranylgeranyl Diphosphate Synthase by Bisphosphonates and Diphosphates:  A Potential Route to New Bone Antiresorption and Antiparasitic Agents by Szabo, Christina M, Matsumura, Yoshihiro, Fukura, Sayaka, Martin, Michael B, Sanders, John M, Sengupta, Suraj, Cieslak, John A, Loftus, Timothy C, Lea, Christopher R, Lee, Hyung-Jae, Koohang, Ali, Coates, Robert M, Sagami, Hiroshi, Oldfield, Eric

“…We report the inhibition of a human recombinant geranylgeranyl diphosphate synthase (GGPPSase) by 23 bisphosphonates and six azaprenyl diphosphates. The IC50…”
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Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics by Brinson, Robert G, Marino, John P, Delaglio, Frank, Arbogast, Luke W, Evans, Ryan M, Kearsley, Anthony, Gingras, Geneviève, Ghasriani, Houman, Aubin, Yves, Pierens, Gregory K, Jia, Xinying, Mobli, Mehdi, Grant, Hamish G, Keizer, David W, Schweimer, Kristian, Ståhle, Jonas, Widmalm, Göran, Zartler, Edward R, Lawrence, Chad W, Reardon, Patrick N, Cort, John R, Xu, Ping, Ni, Feng, Yanaka, Saeko, Kato, Koichi, Parnham, Stuart R, Tsao, Desiree, Blomgren, Andreas, Rundlöf, Torgny, Trieloff, Nils, Schmieder, Peter, Ross, Alfred, Skidmore, Ken, Chen, Kang, Keire, David, Freedberg, Darón I, Suter-Stahel, Thea, Wider, Gerhard, Ilc, Gregor, Plavec, Janez, Bradley, Scott A, Baldisseri, Donna M, Sforça, Mauricio Luis, Zeri, Ana Carolina de Mattos, Wei, Julie Yu, Szabo, Christina M, Amezcua, Carlos A, Jordan, John B, Wikström, Mats

“…The increased interest in using monoclonal antibodies (mAbs) as a platform for biopharmaceuticals has led to the need for new analytical techniques that can…”
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Screening of complex fucoidans from four brown algae species as procoagulant agents by Zhang, Zhenqing, Till, Susanne, Knappe, Sabine, Quinn, Catherine, Catarello, James, Ray, G. Joseph, Scheiflinger, Friedrich, Szabo, Christina M., Dockal, Michael

“…•Selected fucoidan species normalize thrombin generation of hemophilic plasma.•Fucoidans differ in undesired contact activation or in content of…”
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Correction to Complete Structural Elucidation of an Oxidized Polysialic Acid Drug Intermediate by Nuclear Magnetic Resonance Spectroscopy by Ray, G. Joseph, Ravenscroft, Neil, Siekmann, Jürgen, Zhang, Zhenqing, Sanders, Paul, Shaligram, Umesh, Szabo, Christina M, Kosma, Paul

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Reaction of Oxidized Polysialic Acid and a Diaminooxy Linker: Characterization and Process Optimization Using Nuclear Magnetic Resonance Spectroscopy by Ray, G. Joseph, Siekmann, Jürgen, Scheinecker, Richard, Zhang, Zhenqing, Gerasimov, Mikhail V., Szabo, Christina M., Kosma, Paul

“…Native polysialic acid (natPSA) is a high-molecular-weight glycan composed of repeat units of α-(2 → 8) linked N-acetylneuraminic acid (Neu5Ac). Mild periodate…”
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Metabolic profiling of normal and hypertensive rat kidney tissues by hrMAS-NMR spectroscopy by Huhn, Stephen D, Szabo, Christina M, Gass, Jerome H, Manzi, Adriana E

“…Intact kidney tissue samples of normal and spontaneously hypertensive rats (SHRs) were analyzed by hrMAS-NMR spectroscopy and principal component analysis…”
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Complete Structural Elucidation of an Oxidized Polysialic Acid Drug Intermediate by Nuclear Magnetic Resonance Spectroscopy by Ray, G. Joseph, Ravenscroft, Neil, Siekmann, Jürgen, Zhang, Zhenqing, Sanders, Paul, Shaligram, Umesh, Szabo, Christina M, Kosma, Paul

“…Polysialic acid (PSA) is a high molecular weight glycan composed of repeat units of α(2→8) linked 5-N-acetyl-neuraminic acid. Mild periodate oxidation of PSA…”
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The effect of oral care on intracranial pressure: a review of the literature by Szabo, Christina M

“…Neuroscience intensive care unit nurses routinely perform oral care on patients with intracranial pressure (ICP) monitoring. When the ICP is elevated or rises…”
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1H NMR study of the phase behavior of aqueous eutectic solutions using the inverse Laplace transform analysis of T2 relaxation by Baughman, Jessi A., Joseph Ray, G., Christina, Szabo M., Werling, Jane O., Rinaldi, Peter L.

“…High‐field 1H NMR T2 relaxation studies were used to characterize the changes in the physical phases of water, NaCl, and dextrose solutions over a temperature…”
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1 H NMR study of the phase behavior of aqueous eutectic solutions using the inverse Laplace transform analysis of T 2 relaxation by Baughman, Jessi A, Joseph Ray, G, Christina, Szabo M, Werling, Jane O, Rinaldi, Peter L

“…High-field H NMR T relaxation studies were used to characterize the changes in the physical phases of water, NaCl, and dextrose solutions over a temperature…”
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The effect of oral care on intracranial pressure in critically ill adults by Szabo, Christina M, Grap, Mary Jo, Munro, Cindy L, Starkweather, Angela, Merchant, Randall E

“…A major goal in the care of patients with neurological problems is to prevent or minimize episodes of increased intracranial pressure (ICP). Elevations in ICP…”
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NMR of heparin API: investigation of unidentified signals in the USP-specified range of 2.12-3.00 ppm by Lee, Sarah E, Chess, Edward K, Rabinow, Barrett, Ray, G. Joseph, Szabo, Christina M, Melnick, Bennett, Miller, Reagan L, Nair, Lakshmy M, Moore, Edwin G

“…This article addresses the identification and quantification of the chemical species resulting in resonances at 2.17 and 2.25 ppm in the ¹H nuclear magnetic…”
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An Investigation of Bone Resorption and Dictyostelium discoideum Growth Inhibition by Bisphosphonate Drugs by Szabo, Christina M, Martin, Michael B, Oldfield, Eric

“…We report the results of 3D-QSAR/CoMFA investigations of the activity of bisphosphonate drugs, farnesyl pyrophosphate synthase (FPPSase) inhibitors, in the…”
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Sexuality and Spinal Cord Injury by Ricciardi, Richard, Szabo, Christina M., Poullos, Amy Yribarren

“…In the United States, more than 250,000 people are living with spinal cord injury (SCI). SCI is most often the result of direct trauma to the spinal cord, but…”
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More Peptides and Other Diverse Constituents of the Marine Mollusk Philinopsis speciosa by Nakao, Yoichi, Yoshida, Wesley Y, Szabo, Christina M, Baker, Bill J, Scheuer, Paul J

“…In addition to five new depsipeptides related to kulolide-1 (1), further examination of the mollusk Philinopsis speciosa has yielded a linear peptide,…”
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1 H NMR study of the phase behavior of aqueous eutectic solutions using the inverse Laplace transform analysis of T2 relaxation by Baughman, Jessi A, Joseph Ray, G, Christina, Szabo M, Werling, Jane O, Rinaldi, Peter L

“…High-field 1 H NMR T2 relaxation studies were used to characterize the changes in the physical phases of water, NaCl, and dextrose solutions over a temperature…”
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