Search Results - "Christin, John R."

Lineage-Biased Stem Cells Maintain Estrogen-Receptor-Positive and -Negative Mouse Mammary Luminal Lineages by Wang, Chunhui, Christin, John R., Oktay, Maja H., Guo, Wenjun

“…Delineating the mammary differentiation hierarchy is important for the study of mammary gland development and tumorigenesis. Mammary luminal cells are…”
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Cholinergic Signals from the CNS Regulate G-CSF-Mediated HSC Mobilization from Bone Marrow via a Glucocorticoid Signaling Relay by Pierce, Halley, Zhang, Dachuan, Magnon, Claire, Lucas, Daniel, Christin, John R., Huggins, Matthew, Schwartz, Gary J., Frenette, Paul S.

“…Hematopoietic stem cells (HSCs) are mobilized from niches in the bone marrow (BM) to the blood circulation by the cytokine granulocyte colony-stimulating…”
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Mammary-Stem-Cell-Based Somatic Mouse Models Reveal Breast Cancer Drivers Causing Cell Fate Dysregulation by Zhang, Zheng, Christin, John R., Wang, Chunhui, Ge, Kai, Oktay, Maja H., Guo, Wenjun

“…Cancer genomics has provided an unprecedented opportunity for understanding genetic causes of human cancer. However, distinguishing which mutations are…”
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Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation by Donnelly, Sara K, Cabrera, Ramon, Mao, Serena P H, Christin, John R, Wu, Bin, Guo, Wenjun, Bravo-Cordero, Jose Javier, Condeelis, John S, Segall, Jeffrey E, Hodgson, Louis

“…The initial step of metastasis is the local invasion of tumor cells into the surrounding tissue. Invadopodia are actin-based protrusions that mediate the…”
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A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses by Wec, Anna Z., Nyakatura, Elisabeth K., Herbert, Andrew S., Howell, Katie A., Holtsberg, Frederick W., Bakken, Russell R., Mittler, Eva, Christin, John R., Shulenin, Sergey, Jangra, Rohit K., Bharrhan, Sushma, Kuehne, Ana I., Bornholdt, Zachary A., Flyak, Andrew I., Saphire, Erica Ollmann, Crowe, James E., Aman, M. Javad, Dye, John M., Lai, Jonathan R., Chandran, Kartik

“…There is an urgent need for monoclonal antibody (mAb) therapies that broadly protect against Ebola virus and other filoviruses. The conserved, essential…”
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Loss of amphiregulin reduces myoepithelial cell coverage of mammary ducts and alters breast tumor growth by Mao, Serena P H, Park, Minji, Cabrera, Ramon M, Christin, John R, Karagiannis, George S, Oktay, Maja H, Zaiss, Dietmar M W, Abrams, Scott I, Guo, Wenjun, Condeelis, John S, Kenny, Paraic A, Segall, Jeffrey E

“…Amphiregulin (AREG), a ligand of the epidermal growth factor receptor, is not only essential for proper mammary ductal development, but also associated with…”
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Stem Cell Determinant SOX9 Promotes Lineage Plasticity and Progression in Basal-like Breast Cancer by Christin, John R., Wang, Chunhui, Chung, Chi-Yeh, Liu, Yu, Dravis, Christopher, Tang, Wei, Oktay, Maja H., Wahl, Geoffrey M., Guo, Wenjun

“…Lineage plasticity is important for the development of basal-like breast cancer (BLBC), an aggressive cancer subtype. While BLBC is likely to originate from…”
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A SOX9-B7x axis safeguards dedifferentiated tumor cells from immune surveillance to drive breast cancer progression by Liu, Yu, John, Peter, Nishitani, Kenta, Cui, Jihong, Nishimura, Christopher D, Christin, John R, Couturier, Nicole, Ren, Xiaoxin, Wei, Yao, Pulanco, Marc C, Galbo, Jr, Phillip M, Zhang, Xusheng, Fu, Wenyan, Cui, Wei, Bartholdy, Boris A, Zheng, Deyou, Lauvau, Gregoire, Fineberg, Susan A, Oktay, Maja H, Zang, Xingxing, Guo, Wenjun

“…How dedifferentiated stem-like tumor cells evade immunosurveillance remains poorly understood. We show that the lineage-plasticity regulator SOX9, which is…”
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Modeling tumor plasticity in organoid models of human cancer by Christin, John R, Shen, Michael M

“…Due to its inherent plasticity and heterogeneity, cancer is a difficult disease to model both in vitro and in vivo. However, recent advances in organoid…”
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Targeting ABCA12-controlled ceramide homeostasis inhibits breast cancer stem cell function and chemoresistance by Cui, Jihong, Christin, John R, Reisz, Julie A, Cendali, Francesca Isabelle, Sanawar, Rahul, Coutinho De Miranda, Marcelo, D'Alessandro, Angelo, Guo, Wenjun

“…Cancer stem cells (CSCs) drive tumor growth, metastasis, and chemoresistance. While emerging evidence suggests that CSCs have a unique dependency on lipid…”
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Homologous Elements hs3a and hs3b in the 3′ Regulatory Region of the Murine Immunoglobulin Heavy Chain (Igh) Locus Are Both Dispensable for Class-switch Recombination by Yan, Yi, Pieretti, Joyce, Ju, Zhongliang, Wei, Shiniu, Christin, John R., Bah, Fatmata, Birshtein, Barbara K., Eckhardt, Laurel A.

“…Immunoglobulin heavy chain (IgH) genes are formed, tested, and modified to yield diverse, specific, and high affinity antibody responses to antigen. The…”
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MP65-08 OPTIMIZING AN ORGANOID ASSAY FOR PREDICTING INTRAVESICAL THERAPY RESPONSE IN LOW-GRADE INTERMEDIATE RISK NON-MUSCLE INVASIVE BLADDER CANCER by Joffe, Benjamin I., Christin, John R., Le Coz, Clémentine, Laplaca, Caroline, DeCastro, G. Joel, Anderson, Christopher B., McKiernan, James M., Shen, Michael, Lenis, Andrew T.

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MP15-16 MOLECULAR CHARACTERIZATION OF BLADDER CANCER TUMOR INVASION USING SINGLE-CELL DNA SEQUENCING by Joffe, Benjamin I., Le Coz, Clémentine, Wang, Zejian, Christin, John R., Laplaca, Caroline, DeCastro, G. Joel, Anderson, Christopher B., McKiernan, James M., Shen, Michael, Lenis, Andrew T.

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MP15-15 CHARACTERIZATION OF BLADDER CARCINOMA IN SITU USING SINGLE-CELL DNA SEQUENCING by Joffe, Benjamin I., Le Coz, Clémentine, Wang, Zejian, Christin, John R., Laplaca, Caroline, DeCastro, G. Joel, Anderson, Christopher B., McKiernan, James M., Shen, Michael, Lenis, Andrew T.

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Abstract B009: A SOX9-B7x axis safeguards dedifferentiated tumor cells from immunosurveillance to enable DCIS progression by Liu, Yu, John, Peter, Christin, John R, Oktay, Maja, Zang, XingXing, Guo, Wenjun

“…Abstract Accumulating evidence has demonstrated a central role of dedifferentiation in carcinogenesis. In basal-like breast cancer mouse models, upregulation…”
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MP16-18 COMBINATION REGIMEN OF INTRAVESICAL DOCETAXEL, GEMCITABINE, AND CISPLATIN IN PATIENTS WITH BCG-UNRESPONSIVE NON-MUSCLE INVASIVE UROTHELIAL CARCINOMA OF THE BLADDER by Joffe, Benjamin I., Christin, John R., Le Coz, Clémentine, Pak, Jamie S., Laplaca, Caroline, Reyes, Helena Vila, DeCastro, G. Joel, Anderson, Christopher B., Abate-Shen, Cory, McKiernan, James M., Lenis, Andrew T.

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Abstract B47: Validation of novel breast cancer drivers using mammary stem cell-based somatic mouse models by Zhang, Zheng, Christin, John R., Wang, Chunhui, Ge, Kai, Oktay, Maja, Guo, Wenjun

“…Abstract Cancer genomics has provided an unprecedented opportunity for understanding genetic causes of human cancer. However, distinguishing which mutations…”
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Abstract B025: Luminal-to-basal phenotypic plasticity promotes invasive phenotypes in a live-imaging assay using patient-derived bladder tumor organoids by Coz, Clementine Le, Christin, John R., Syed, Talal, Wang, Zejian, Laplaca, Caroline J., Lenis, Andrew T., Shen, Michael M.

“…Abstract Lineage plasticity in cancer is characterized by changes in cell state that are often associated with tumor progression and treatment resistance…”
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Abstract 5931: Characterizing tumor heterogeneity through bulk and single cell analysis of patient derived bladder cancer models by Chen, Ziyu, Tang, Xinran, Havasov, Eliyahu, Mcpherson, Andrew, Chu, Carissa, Christin, John R., Berger, Michael F., Schultz, Nikolaus D., de Stanchina, Elisa, Shen, Michael M., Al-Ahmadie, Hikmat, Kim, Kwanghee, Iyer, Gopa, Solit, David B.

“…Abstract Background: A major hurdle to the development of novel targeted therapies for bladder cancer is the lack of preclinical models that reflect the…”
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Abstract A028: A living biobank of patient-derived organoids reveals a role for KMT2D in maintaining luminal identity in urothelial carcinoma by Christin, John R., Nguyen, Alana, Syed, Talal, Kim, Kwanghee, Coz, Clementine Le, Laplaca, Caroline J., Pina, Luis A., Akabas, Reuben, Hibshoosh, Hanina, Lenis, Andrew T., Decastro, Guarionex J., Anderson, Christopher B., McKiernan, James M., Lu, Chao, Al-Ahmadie, Hikmat A., Solit, David B., Shen, Michael M.

“…Abstract Patient-derived organoid models provide a highly amenable experimental platform to study human tumor biology. Over the past seven years, our group has…”
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