Search Results - "Christie, A"

Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants by Walton, Russell T, Christie, Kathleen A, Whittaker, Madelynn N, Kleinstiver, Benjamin P

“…Manipulation of DNA by CRISPR-Cas enzymes requires the recognition of a protospacer-adjacent motif (PAM), limiting target site recognition to a subset of…”
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Distribution of plastic polymer types in the marine environment; A meta-analysis by Erni-Cassola, Gabriel, Zadjelovic, Vinko, Gibson, Matthew I., Christie-Oleza, Joseph A.

“…[Display omitted] •Incidence of common polymers is similar in intertidal- and shallow subtidal sediments.•Open oceans favours segregation of microplastic…”
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Marine Plastic Debris: A New Surface for Microbial Colonization by Wright, Robyn J, Erni-Cassola, Gabriel, Zadjelovic, Vinko, Latva, Mira, Christie-Oleza, Joseph A

“…Plastics become rapidly colonized by microbes when released into marine environments. This microbial communitythe Plastispherehas recently sparked a…”
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Women Physicians and Promotion in Academic Medicine by Richter, Kimber P, Clark, Lauren, Wick, Jo A, Cruvinel, Erica, Durham, Dianne, Shaw, Pamela, Shih, Grace H, Befort, Christie A, Simari, Robert D

“…In analyses of data on graduates from all U.S. medical schools from 1979 through 2013, women were less likely than men to be promoted from assistant to…”
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Diet and the Human Gut Microbiome: An International Review by Wilson, Annette S., Koller, Kathryn R., Ramaboli, Matsepo C., Nesengani, Lucky T., Ocvirk, Soeren, Chen, Caixia, Flanagan, Christie A., Sapp, Flora R., Merritt, Zoe T., Bhatti, Faheem, Thomas, Timothy K., O’Keefe, Stephen J. D.

“…This review summarizes the key results of recently published studies on the effects of dietary change and nutritional intervention on the human microbiome from…”
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Prevalence of Obesity Among Adults From Rural and Urban Areas of the United States: Findings From NHANES (2005-2008) by Befort, Christie A., Nazir, Niaman, Perri, Michael G.

“…Purpose: Rural residents have higher rates of chronic diseases compared to their urban counterparts, and obesity may be a major contributor to this disparity…”
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Cutaneous Leishmaniasis: Updates in Diagnosis and Management by Aronson, Naomi E, Joya, Christie A

“…Cutaneous leishmaniasis (CL) is a diverse human disease caused by more than 20 Leishmania species transmitted by the bite of an infected sand fly. Diagnostic…”
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Impacts of Shale Gas Wastewater Disposal on Water Quality in Western Pennsylvania by Warner, Nathaniel R, Christie, Cidney A, Jackson, Robert B, Vengosh, Avner

“…The safe disposal of liquid wastes associated with oil and gas production in the United States is a major challenge given their large volumes and typically…”
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Transforming Growth Factor β1 Function in Airway Remodeling and Hyperresponsiveness. The Missing Link? by Ojiaku, Christie A, Yoo, Edwin J, Panettieri, Jr, Reynold A

“…The pathogenesis of asthma includes a complex interplay among airway inflammation, hyperresponsiveness, and remodeling. Current evidence suggests that airway…”
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Beyond oil degradation: enzymatic potential of Alcanivorax to degrade natural and synthetic polyesters by Zadjelovic, Vinko, Chhun, Audam, Quareshy, Mussa, Silvano, Eleonora, Hernandez‐Fernaud, Juan R., Aguilo‐Ferretjans, María M., Bosch, Rafael, Dorador, Cristina, Gibson, Matthew I., Christie‐Oleza, Joseph A.

“…Summary Pristine marine environments are highly oligotrophic ecosystems populated by well‐established specialized microbial communities. Nevertheless, during…”
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Forecasting insect dynamics in a changing world by Bahlai, Christie A

“…Predicting how insects will respond to stressors through time is difficult because of the diversity of insects, environments, and approaches used to monitor…”
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Risk factors for depressive symptoms during pregnancy: a systematic review by Lancaster, Christie A., MD, MS, Gold, Katherine J., MD, MSW, MS, Flynn, Heather A., PhD, Yoo, Harim, Marcus, Sheila M., MD, Davis, Matthew M., MD, MAPP

“…The purpose of this study was to evaluate risk factors for antepartum depressive symptoms that can be assessed in routine obstetric care. We evaluated articles…”
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Engineering overexpression of ORCA3 and strictosidine glucosidase in Catharanthus roseus hairy roots increases alkaloid production by Sun, Jiayi, Peebles, Christie A. M.

“…Catharanthus roseus produces many pharmaceutically important terpenoid indole alkaloids (TIAs) such as vinblastine, vincristine, ajmalicine, and serpentine…”
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Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease by McAlpine, Cameron S., Park, Joseph, Griciuc, Ana, Kim, Eunhee, Choi, Se Hoon, Iwamoto, Yoshiko, Kiss, Máté G., Christie, Kathleen A., Vinegoni, Claudio, Poller, Wolfram C., Mindur, John E., Chan, Christopher T., He, Shun, Janssen, Henrike, Wong, Lai Ping, Downey, Jeffrey, Singh, Sumnima, Anzai, Atsushi, Kahles, Florian, Jorfi, Mehdi, Feruglio, Paolo Fumene, Sadreyev, Ruslan I., Weissleder, Ralph, Kleinstiver, Benjamin P., Nahrendorf, Matthias, Tanzi, Rudolph E., Swirski, Filip K.

“…Communication within the glial cell ecosystem is essential for neuronal and brain health 1 – 3 . The influence of glial cells on the accumulation and clearance…”
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How long do population level field experiments need to be? Utilising data from the 40‐year‐old LTER network by Cusser, Sarah, Helms, Jackson, Bahlai, Christie A., Haddad, Nick M., Chase, Jonathan

“…We utilise the wealth of data accessible through the 40‐year‐old Long‐Term Ecological Research (LTER) network to ask if aspects of the study environment or…”
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Phosphoinositide 3-Kinase in Asthma: Novel Roles and Therapeutic Approaches by Yoo, Edwin J, Ojiaku, Christie A, Sunder, Krishna, Panettieri, Jr, Reynold A

“…Asthma manifests as airway hyperresponsiveness and inflammation, including coughing, wheezing, and shortness of breath. Immune cells and airway structural…”
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Hairy roots: An untapped potential for production of plant products by Morey, Kevin J., Peebles, Christie A. M.

“…While plants are an abundant source of valuable natural products, it is often challenging to produce those products for commercial application. Often organic…”
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Ecospheric life cycle impacts of annual global space activities by Wilson, Andrew Ross, Vasile, Massimiliano, Maddock, Christie A., Baker, Keith J.

“…This paper presents a first-order approximation of ecospheric life cycle impacts from annual global space activities across two scenarios using a streamlined…”
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A novel alcohol+nicotine co-use self-administration procedure reveals sex differences and differential alteration of mesocorticolimbic TLR- and cholinergic-related neuroimmune gene expression in rats by Randall, Christie A., Sun, Dongxiao, Randall, Patrick A.

“…Although alcohol and nicotine are two of the most commonly co-used drugs with upwards of 90% of adults with an alcohol use disorder (AUD) in the US also…”
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Data gap or biodiversity gap? Evaluating apparent spatial biases in community science observations of Odonata in the east-central United States by Bullion, Christian M, Bahlai, Christie A

“…Odonates (dragonflies and damselflies) have become popular study organisms for insect-based climate studies, due to the taxon's strong sensitivity to…”
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