Search Results - "Christians, U."

Development and validation of an LC-MS/MS assay for the quantification of allopregnanolone and its progesterone-derived isomers, precursors, and cortisol/cortisone in pregnancy by Mayne, G., De Bloois, E., Dabelea, D., Christians, U.

“…Neuroactive steroids are potent neuromodulators that play a critical role in both maternal and fetal health during pregnancy. These stress-responsive compounds…”
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Development of a Physiologically‐Based Pharmacokinetic Model for Sirolimus: Predicting Bioavailability Based on Intestinal CYP3A Content by Emoto, C, Fukuda, T, Cox, S, Christians, U, Vinks, AA

“…Sirolimus is an inhibitor of mammalian target of rapamycin (mTOR) and is increasingly being used in transplantation and cancer therapies. Sirolimus has low…”
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Mechanisms of clinically relevant drug interactions associated with tacrolimus by Christians, Uwe, Jacobsen, Wolfgang, Benet, Leslie Z, Lampen, Alfonso

“…The clinical management of tacrolimus, a macrolide used as immunosuppressant after transplantation, is complicated by its narrow therapeutic index in…”
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Time-dependent effects of imatinib in human leukaemia cells: a kinetic NMR-profiling study by Klawitter, J, Anderson, N, Klawitter, J, Christians, U, Leibfritz, D, Eckhardt, S G, Serkova, N J

“…The goal of this study was to evaluate the time course of metabolic changes in leukaemia cells treated with the Bcr-Abl tyrosine kinase inhibitor imatinib…”
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SLCO1B1 Genotype Influences the Drug-Drug Interaction between Cyclosporine and Pravastatin by Aquilante, C.L, Page, R.L, Brieke, A, Hopley, C.W, Christians, U, Hoffman, K.L, Schniedewind, B

“…Purpose Cyclosporine (CYA) increases pravastatin (PRAV) plasma exposure by inhibiting the OATP1B1 ( SLCO1B1 ) transporter. The aim of this study was to…”
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515 Everolimus for Calcineurin Inhibitor Minimization in Lung Transplant Recipients with Chronic Renal Insufficiency by Schoeppler, K, Lyu, D, Kim, I, Grazia, T, Crossno, J, Christians, U, Zamora, M.R

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Comparison of the in vitro metabolism of the macrolide immunosuppressants sirolimus and RAD by Jacobsen, W, Serkova, N, Hausen, B, Morris, R.E, Benet, L.Z, Christians, U

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Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability by Lampen, A, Christians, U, Guengerich, F P, Watkins, P B, Kolars, J C, Bader, A, Gonschior, A K, Dralle, H, Hackbarth, I, Sewing, K F

“…The small intestinal metabolism of tacrolimus, which is used as an immunosuppressant in transplantation medicine, was investigated in this study. Tacrolimus…”
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Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat by Sattler, M, Guengerich, F P, Yun, C H, Christians, U, Sewing, K F

“…The hepatic cytochrome P-450 responsible for metabolism of the structurally related macrolides FK506 and rapamycin in humans was identified using in vitro…”
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Cyclosporin metabolism in transplant patients by Christians, U, Sewing, K F

“…The immunosuppressant cyclosporin, a cyclic undecapeptide, is metabolized to more than 30 metabolites. Cytochrome P450IIIA enzymes located in liver and small…”
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In Vitro Evaluation of the Disposition of A Novel Cysteine Protease Inhibitor by JACOBSEN, Wolfgang, CHRISTIANS, Uwe, BENET, Leslie Z

“…K11777 ( N -methyl-piperazine-Phe-homoPhe-vinylsulfone-phenyl) is a potent, irreversible cysteine protease inhibitor. Its therapeutic targets are cruzain, a…”
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Effect of hepatitis C infection on tacrolimus doses and blood levels in liver transplantation recipients by TROTTER, J. F., OSBORNE, J. C., HELLER, M., CHRISTIANS, U.

“…Summary Background : In our cohort of patients with hepatitis‐C virus, which is the most common indication for liver transplantation, we have noted higher…”
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Biochemical Mechanisms of Cyclosporine Neurotoxicity by Serkova, Natalie J, Christians, Uwe, Benet, Leslie Z

“…Proper management of chemotoxicity in transplant patients requires detailed knowledge of the biochemical mechanisms underlying immunosuppressant toxicity…”
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Metabolism of Sirolimus and Its Derivative Everolimus by Cytochrome P450 3A4:  Insights from Docking, Molecular Dynamics, and Quantum Chemical Calculations by Kuhn, Bernd, Jacobsen, Wolfgang, Christians, Uwe, Benet, Leslie Z, Kollman, Peter A

“…A combination of quantum chemical calculations and molecular simulations (DOCKing and molecular dynamics) is used to investigate the metabolism of sirolimus…”
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Coadministration of either cyclosporine or steroids with humanized monoclonal antibodies against CD80 and CD86 successfully prolong allograft survival after life supporting renal transplantation in cynomolgus monkeys by HAUSEN, Bernard, KLUPP, Jochen, CHRISTIANS, U. W. E, HIGGINS, John P, BAUMGARTNER, Roxanne E, HOOK, Laurie E, FRIEDRICH, Stuart, CELNICKER, Abbie, MORRIS, Randall E

“…Recent studies have shown some efficacy using monotherapy with monoclonal antibodies (mAb) against CD80 and CD86 receptors after life-supporting renal…”
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Worsening of long-term myocardial function after successful pharmacological pretreatment with cyclosporine by Laudi, S, Weimann, J, Haschke, M, Trump, S, Schmitz, V, Christians, U, Kaisers, U, Steudel, W

“…Pretreatment with cyclosporine (CsA) decreases infarct size 24h after myocardial ischemia/reperfusion (I/R). The goal of this study was to determine effects of…”
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Biotransformation of cyclosporin in primary rat, porcine and human liver cell co-cultures by Schmelzer, E., Acikgoez, A., Frühauf, N. R., Crome, O., Klempnauer, J., Christians, U., Bader, A.

“…The purpose of this study was to investigate the species-specific cyclosporin biotransformation in primary rat, human, and porcine liver cell cultures, and to…”
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Combined immunosuppression with cyclosporine (NEORAL) and SDZ RAD in non-human primate lung transplantation : Systematic pharmacokinetic-based trials to improve efficacy and tolerability by HAUSEN, B, IKONEN, T, MORRIS, R. E, BRIFFA, N, BERRY, G. J, CHRISTIANS, U, ROBBINS, R. C, HOOK, L, SERKOVA, N, BENET, L. Z, SCHULER, W

“…We studied the efficacy and tolerability of combined immunosuppressive therapy with cyclosporine A microemulsion (Neoral) plus the macrolide SDZ RAD 40-0…”
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Sensitive and specific quantification of sirolimus (rapamycin) and its metabolites in blood of kidney graft recipients by HPLC/electrospray- mass spectrometry by Streit, F, Christians, U, Schiebel, HM, Napoli, KL, Ernst, L, Linck, A, Kahan, BD, Sewing, KF

“…Sirolimus (rapamycin) has a macrolide structure and is under clinical investigation as an immunosuppressant after organ transplantation. An HPLC/mass…”
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79 IMMUNOASSAY CROSS-REACTIVITY TESTING OF THE MAJOR EVEROLIMUS METABOLITES IN THE BLOOD OF KIDNEY TRANSPLANT PATIENTS by Strom, T., Christians, U., Chan, L.

“…Everolimus was developed for use with cyclosporine as a new immunosuppressant in the prevention of rejection in transplant patients. It binds to FK binding…”
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