Search Results - "Christian M. Orr"

Light activation of Orange Carotenoid Protein reveals bicycle-pedal single-bond isomerization by Chukhutsina, Volha U., Baxter, James M., Fadini, Alisia, Morgan, Rhodri M., Pope, Matthew A., Maghlaoui, Karim, Orr, Christian M., Wagner, Armin, van Thor, Jasper J.

“…Orange Carotenoid protein (OCP) is the only known photoreceptor which uses carotenoid for its activation. It is found exclusively in cyanobacteria, where it…”
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Characterization of two putative Dichelobacter nodosus footrot vaccine antigens identifies the first lysozyme inhibitor in the genus by Humbert, Maria Victoria, Jackson, Alexandra, Orr, Christian M., Tews, Ivo, Christodoulides, Myron

“…The Gram-negative anaerobic bacterium Dichelobacter nodosus (Dn) causes footrot in ruminants, a debilitating and highly contagious disease that results in…”
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Reducing affinity as a strategy to boost immunomodulatory antibody agonism by Yu, Xiaojie, Orr, Christian M., Chan, H. T. Claude, James, Sonya, Penfold, Christine A., Kim, Jinny, Inzhelevskaya, Tatyana, Mockridge, C. Ian, Cox, Kerry L., Essex, Jonathan W., Tews, Ivo, Glennie, Martin J., Cragg, Mark S.

“…Antibody responses during infection and vaccination typically undergo affinity maturation to achieve high-affinity binding for efficient neutralization of…”
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Utilizing anomalous signals for element identification in macromolecular crystallography by El Omari, Kamel, Forsyth, Ismay, Duman, Ramona, Orr, Christian M., Mykhaylyk, Vitaliy, Mancini, Erika J., Wagner, Armin

“…AlphaFold2 has revolutionized structural biology by offering unparalleled accuracy in predicting protein structures. Traditional methods for determining…”
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Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies by Yu, Xiaojie, Chan, H.T. Claude, Orr, Christian M., Dadas, Osman, Booth, Steven G., Dahal, Lekh N., Penfold, Christine A., O'Brien, Lyn, Mockridge, C. Ian, French, Ruth R., Duriez, Patrick, Douglas, Leon R., Pearson, Arwen R., Cragg, Mark S., Tews, Ivo, Glennie, Martin J., White, Ann L.

“…Anti-CD40 monoclonal antibodies (mAbs) that promote or inhibit receptor function hold promise as therapeutics for cancer and autoimmunity. Rules governing…”
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Serial Femtosecond Crystallography Reveals that Photoactivation in a Fluorescent Protein Proceeds via the Hula Twist Mechanism by Fadini, Alisia, Hutchison, Christopher D.M., Morozov, Dmitry, Chang, Jeffrey, Maghlaoui, Karim, Perrett, Samuel, Luo, Fangjia, Kho, Jeslyn C.X., Romei, Matthew G., Morgan, R. Marc L., Orr, Christian M., Cordon-Preciado, Violeta, Fujiwara, Takaaki, Nuemket, Nipawan, Tosha, Takehiko, Tanaka, Rie, Owada, Shigeki, Tono, Kensuke, Iwata, So, Boxer, Steven G., Groenhof, Gerrit, Nango, Eriko, van Thor, Jasper J.

“…Chromophore cis/trans photoisomerization is a fundamental process in chemistry and in the activation of many photosensitive proteins. A major task is…”
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Molecular mechanism of Mad1 kinetochore targeting by phosphorylated Bub1 by Fischer, Elyse S, Yu, Conny W H, Bellini, Dom, McLaughlin, Stephen H, Orr, Christian M, Wagner, Armin, Freund, Stefan M V, Barford, David

“…During metaphase, in response to improper kinetochore-microtubule attachments, the spindle assembly checkpoint (SAC) activates the mitotic checkpoint complex…”
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Evaluating Anti-CD32b F(ab) Conformation Using Molecular Dynamics and Small-Angle X-Ray Scattering by Sutton, Emma J., Bradshaw, Richard T., Orr, Christian M., Frendéus, Bjorn, Larsson, Gunilla, Teige, Ingrid, Cragg, Mark S., Tews, Ivo, Essex, Jonathan W.

“…Complementary strategies of small-angle x-ray scattering (SAXS) and crystallographic analysis are often used to determine atomistic three-dimensional models of…”
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Embedding AI in the Protein Crystallography Workflow by J. Gildea, Richard, Orr, Christian M., Paterson, Neil G., Hall, David R.

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Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility by Orr, Christian M, Fisher, Hayden, Yu, Xiaojie, Chan, Claude H-T, Gao, Yunyun, Duriez, Patrick J, Booth, Steven G, Elliott, Isabel, Inzhelevskaya, Tatyana, Mockridge, Ian, Penfold, Christine A, Wagner, Armin, Glennie, Martin J, White, Ann L, Essex, Jonathan W, Pearson, Arwen R, Cragg, Mark S, Tews, Ivo

“…Antibodies protect from infection, underpin successful vaccines and elicit therapeutic responses in otherwise untreatable cancers and autoimmune conditions…”
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Experimental phasing opportunities for macromolecular crystallography at very long wavelengths by El Omari, Kamel, Duman, Ramona, Mykhaylyk, Vitaliy, Orr, Christian M., Latimer-Smith, Merlyn, Winter, Graeme, Grama, Vinay, Qu, Feng, Bountra, Kiran, Kwong, Hok Sau, Romano, Maria, Reis, Rosana I., Vogeley, Lutz, Vecchia, Luca, Owen, C. David, Wittmann, Sina, Renner, Max, Senda, Miki, Matsugaki, Naohiro, Kawano, Yoshiaki, Bowden, Thomas A., Moraes, Isabel, Grimes, Jonathan M., Mancini, Erika J., Walsh, Martin A., Guzzo, Cristiane R., Owens, Raymond J., Jones, E. Yvonne, Brown, David G., Stuart, Dave I., Beis, Konstantinos, Wagner, Armin

“…Despite recent advances in cryo-electron microscopy and artificial intelligence-based model predictions, a significant fraction of structure determinations by…”
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Structure of the Recombinant Neisseria gonorrhoeae Adhesin Complex Protein (rNg-ACP) and Generation of Murine Antibodies with Bactericidal Activity against Gonococci by Almonacid-Mendoza, Hannia Liliana, Humbert, María Victoria, Dijokaite, Aiste, Cleary, David W, Soo, Yiwen, Hung, Miao-Chiu, Orr, Christian M, Machelett, Moritz M, Tews, Ivo, Christodoulides, Myron

“…(gonococcus [Ng]) is the causative organism of the sexually transmitted disease gonorrhoea, and no effective vaccine exists currently. In this study, the…”
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Structure of the Recombinant italic toggle="yes">Neisseria gonorrhoeae /italic> Adhesin Complex Protein (rNg-ACP) and Generation of Murine Antibodies with Bactericidal Activity against Gonococci by Hannia Liliana Almonacid-Mendoza, María Victoria Humbert, Aiste Dijokaite, David W. Cleary, Yiwen Soo, Miao-Chiu Hung, Christian M. Orr, Moritz M. Machelett, Ivo Tews, Myron Christodoulides

“…ABSTRACT Neisseria gonorrhoeae (gonococcus [Ng]) is the causative organism of the sexually transmitted disease gonorrhoea, and no effective vaccine exists…”
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Embedding AI in the Protein Crystallography Workflow by J. Gildea, Richard, Orr, Christian M., Paterson, Neil G., Hall, David R.

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