Search Results - "Christian Ludin"
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Discovery of Highly Potent and Selective CXCR4 Inhibitors Using Protein Epitope Mimetics (PEM) Technology
Published in Chimia (25-04-2007)“…Novel, highly potent CXCR4 inhibitors with good pharmacokinetic properties were obtained by applying PEM technology starting from the naturally occurring…”
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Gas-Selective Optical Sensors for Fire Detectors
Published in Chimia (01-01-2001)“…At the Center for Chemical Sensors (CCS) of ETH-Zürich, gas-sensitive membranes have been developed during the last three years. In co-operation with…”
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Lysophosphatidic Acid Receptors LPA1 and LPA3 Promote CXCL12-Mediated Smooth Muscle Progenitor Cell Recruitment in Neointima Formation
Published in Circulation research (09-07-2010)“…RATIONALE:The chemokine CXCL12 (CXC motif ligand 12) and its receptor CXCR 4 (CXC motif receptor 4) direct the recruitment of smooth muscle progenitor cells…”
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Discovery of novel, highly potent and selective β-hairpin mimetic CXCR4 inhibitors with excellent anti-HIV activity and pharmacokinetic profiles
Published in Bioorganic & medicinal chemistry (15-12-2006)“…Protein epitope mimetics (PEM) of Polyphemusin II act as highly potent CXCR4 inhibitors with good in vivo pharmacokinetic properties. Novel highly potent CXCR4…”
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Targeting CXCR4, SDF1 and Beta-Adrenergic Receptors In the AML Microenvironment by Novel Antagonist POL6326, G-CSF and Isoproterenol
Published in Blood (19-11-2010)“…Abstract 2179 The role of SDF-1α /CXCR4 signaling in leukemia cell/bone marrow microenvironment interactions has recently been established. Activation of CXCR4…”
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First Results of a Phase-II Study with the New CXCR4 Antagonist POL6326 to Mobilize Hematopoietic Stem Cells (HSC) In Multiple Myeloma (MM)
Published in Blood (19-11-2010)“…Abstract 824 In multiple myeloma (MM), the second most common hematological malignancy, high-dose therapy followed by autologous CD34+ stem cell…”
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Lysophosphatidic Acid Receptors LPA 1 and LPA 3 Promote CXCL12-Mediated Smooth Muscle Progenitor Cell Recruitment in Neointima Formation
Published in Circulation research (09-07-2010)“…Rationale : The chemokine CXCL12 (CXC motif ligand 12) and its receptor CXCR 4 (CXC motif receptor 4) direct the recruitment of smooth muscle progenitor cells…”
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8
Gas-Selective Optical Sensors for Fire Detectors
Published in Chimia (01-09-2001)“…At the Center for Chemical Sensors (CCS) of ETH-Zürich, gas-sensitive membranes have been developed during the last three years. In co-operation with…”
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9
Total synthesis of rhizoferrin, an iron chelator
Published in Tetrahedron (13-01-1997)“…The absolute configuration of rhizoferrin, a novel siderophore isolated from the fungus Rhizopus microsporus var. rhizopodiformis, was determined via its total…”
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10
Development of a Hypusine Reagent for Peptide Synthesis
Published in Journal of organic chemistry (16-05-1997)“…The synthesis of a reagent that enables the incorporation of the unusual amino acid (2S,9R)-hypusine (Hpu) into peptide sequences is described. The reagent,…”
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