Search Results - "Christian Flotho"

Juvenile myelomonocytic leukemia: who's the driver at the wheel? by Niemeyer, Charlotte M., Flotho, Christian

“…Juvenile myelomonocytic leukemia (JMML) is a unique clonal hematopoietic disorder of early childhood. It is classified as an overlap…”
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Gene mutations do not operate in a vacuum: the increasing importance of epigenetics in juvenile myelomonocytic leukemia by Flotho, Christian

“…Juvenile myelomonocytic leukemia (JMML) stands out among malignant neoplasms of childhood in several ways. First, JMML is a model condition to elucidate the…”
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The epigenetics of breast cancer - Opportunities for diagnostics, risk stratification and therapy by Schröder, Rieke, Illert, Anna-Lena, Erbes, Thalia, Flotho, Christian, Lübbert, Michael, Duque-Afonso, Jesús

“…The stage and molecular pathology-dependent prognosis of breast cancer, the limited treatment options for triple-negative carcinomas, as well as the…”
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Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia by Stieglitz, Elliot, Mazor, Tali, Olshen, Adam B., Geng, Huimin, Gelston, Laura C., Akutagawa, Jon, Lipka, Daniel B., Plass, Christoph, Flotho, Christian, Chehab, Farid F., Braun, Benjamin S., Costello, Joseph F., Loh, Mignon L.

“…Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative disorder of childhood caused by mutations in the Ras pathway. Outcomes in JMML vary markedly…”
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Genotyping circulating tumor DNA of pediatric Hodgkin lymphoma by Desch, Ann-Kathrin, Hartung, Kristin, Botzen, Ante, Brobeil, Alexander, Rummel, Mathias, Kurch, Lars, Georgi, Thomas, Jox, Theresa, Bielack, Stefan, Burdach, Stefan, Classen, Carl Friedrich, Claviez, Alexander, Debatin, Klaus-Michael, Ebinger, Martin, Eggert, Angelika, Faber, Jörg, Flotho, Christian, Frühwald, Michael, Graf, Norbert, Jorch, Norbert, Kontny, Udo, Kramm, Christof, Kulozik, Andreas, Kühr, Joachim, Sykora, Karl-Walter, Metzler, Markus, Müller, Hermann L., Nathrath, Michaela, Nüßlein, Thomas, Paulussen, Michael, Pekrun, Arnulf, Reinhardt, Dirk, Reinhard, Harald, Rössig, Claudia, Sauerbrey, Axel, Schlegel, Paul-Gerhardt, Schneider, Dominik T., Scheurlen, Wolfram, Schweigerer, Lothar, Simon, Thorsten, Suttorp, Meinolf, Vorwerk, Peter, Schmitz, Roland, Kluge, Regine, Mauz-Körholz, Christine, Körholz, Dieter, Gattenlöhner, Stefan, Bräuninger, Andreas

“…We used hybrid capture-targeted next-generation sequencing of circulating cell-free DNA (ccfDNA) of pediatric Hodgkin lymphoma (PHL) patients to determine…”
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International Consensus Definition of DNA Methylation Subgroups in Juvenile Myelomonocytic Leukemia by Schönung, Maximilian, Meyer, Julia, Nöllke, Peter, Olshen, Adam B, Hartmann, Mark, Murakami, Norihiro, Wakamatsu, Manabu, Okuno, Yusuke, Plass, Christoph, Loh, Mignon L, Niemeyer, Charlotte M, Muramatsu, Hideki, Flotho, Christian, Stieglitz, Elliot, Lipka, Daniel B

“…Known clinical and genetic markers have limitations in predicting disease course and outcome in juvenile myelomonocytic leukemia (JMML). DNA methylation…”
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Induced Pluripotent Stem Cells to Model Juvenile Myelomonocytic Leukemia: New Perspectives for Preclinical Research by Wehbe, Zeinab, Ghanjati, Foued, Flotho, Christian

“…Juvenile myelomonocytic leukemia (JMML) is a malignant myeloproliferative disorder arising in infants and young children. The origin of this neoplasm is…”
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Mutations in CBL occur frequently in juvenile myelomonocytic leukemia by Loh, Mignon L., Sakai, Debbie S., Flotho, Christian, Kang, Michelle, Fliegauf, Manfred, Archambeault, Sophie, Mullighan, Charles G., Chen, Leslie, Bergstraesser, Eva, Bueso-Ramos, Carlos E., Emanuel, Peter D., Hasle, Henrik, Issa, Jean-Pierre, van den Heuvel-Eibrink, Marry M., Locatelli, Franco, Starý, Jan, Trebo, Monica, Wlodarski, Marcin, Zecca, Marco, Shannon, Kevin M., Niemeyer, Charlotte M.

“…Juvenile myelomonocytic leukemia is an aggressive myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell…”
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Long non-coding RNAs as novel therapeutic targets in juvenile myelomonocytic leukemia by Hofmans, Mattias, Lammens, Tim, Depreter, Barbara, Wu, Ying, Erlacher, Miriam, Caye, Aurélie, Cavé, Hélène, Flotho, Christian, de Haas, Valerie, Niemeyer, Charlotte M., Stary, Jan, Van Nieuwerburgh, Filip, Deforce, Dieter, Van Loocke, Wouter, Van Vlierberghe, Pieter, Philippé, Jan, De Moerloose, Barbara

“…Juvenile myelomonocytic leukemia (JMML) treatment primarily relies on hematopoietic stem cell transplantation and results in long-term overall survival of…”
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LIN28B overexpression defines a novel fetal-like subgroup of juvenile myelomonocytic leukemia by Helsmoortel, Hetty H., Bresolin, Silvia, Lammens, Tim, Cavé, Hélène, Noellke, Peter, Caye, Aurélie, Ghazavi, Farzaneh, de Vries, Andrica, Hasle, Henrik, Labarque, Veerle, Masetti, Riccardo, Stary, Jan, van den Heuvel-Eibrink, Marry M., Philippé, Jan, Van Roy, Nadine, Benoit, Yves, Speleman, Frank, Niemeyer, Charlotte, Flotho, Christian, Basso, Giuseppe, te Kronnie, Geertruy, Van Vlierberghe, Pieter, De Moerloose, Barbara

“…Juvenile myelomonocytic leukemia (JMML) is a rare and aggressive stem cell disease of early childhood. RAS activation constitutes the core component of…”
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P1000: JUVENILE MYELOMONOCYTIC LEUKEMIA (JMML) INHIBITS T CELL PROLIFERATION VIA THE ECTONUCLEOTIDASE CD39 AND THE PURINERGIC NETWORK by Rajak, Jovana, Koleci, Naile, Mesesan, Andreea, Flotho, Christian, Niemeyer, Charlotte, Bengsch, Bertram, Erlacher, Miriam

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Azacitidine is effective for targeting leukemia-initiating cells in juvenile myelomonocytic leukemia by Krombholz, Christopher F., Gallego-Villar, Lorena, Sahoo, Sushree S., Panda, Pritam K., Wlodarski, Marcin W., Aumann, Konrad, Hartmann, Mark, Lipka, Daniel B., Daskalakis, Michael, Plass, Christoph, Niemeyer, Charlotte M., Erlacher, Miriam, Flotho, Christian

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Epigenetic dysregulation of the erythropoietic transcription factor KLF1 and the β-like globin locus in juvenile myelomonocytic leukemia by Fluhr, Silvia, Krombholz, Christopher Felix, Meier, Angelina, Epting, Thomas, Mücke, Oliver, Plass, Christoph, Niemeyer, Charlotte M., Flotho, Christian

“…Increased levels of fetal hemoglobin (HbF) are a hallmark of more than half of the children diagnosed with juvenile myelomonocytic leukemia (JMML). Elevated…”
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THE INTERFACE OF EPIGENETICS AND ENERGY METABOLISM IN JUVENILE MYELOMONOCYTIC LEUKEMIA by Wehbe, Zoé, Hammad, Ruba, Cathomen, Toni, Bohler, Sheila, Rajak, Jovana, Erlacher, Miriam, Ghanjati, Foued, Niemeyer, Charlotte, Flotho, Christian

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Gene Expression–Based Classification As an Independent Predictor of Clinical Outcome in Juvenile Myelomonocytic Leukemia by BRESOLIN, Silvia, ZECCA, Marco, TE KRONNIE, Geertruy, LOCATELLI, Franco, BASSO, Giuseppe, FLOTHO, Christian, TRENTIN, Luca, ZANGRANDO, Andrea, SAINATI, Laura, STARY, Jan, DE MOERLOOSE, Barbara, HASLE, Henrik, NIEMEYER, Charlotte M

“…PURPOSE Juvenile myelomonocytic leukemia (JMML) is a rare early childhood myelodysplastic/myeloproliferative disorder characterized by an aggressive clinical…”
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Long-term serial xenotransplantation of juvenile myelomonocytic leukemia recapitulates human disease in Rag2-/-γc-/- mice by Krombholz, Christopher Felix, Aumann, Konrad, Kollek, Matthias, Bertele, Daniela, Fluhr, Silvia, Kunze, Mirjam, Niemeyer, Charlotte M, Flotho, Christian, Erlacher, Miriam

“…Juvenile myelomonocytic leukemia is a clonal malignant disease affecting young children. Current cure rates, even with allogeneic hematopoietic stem cell…”
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The long non-coding RNA landscape in juvenile myelomonocytic leukemia by Hofmans, Mattias, Lammens, Tim, Helsmoortel, Hetty H, Bresolin, Silvia, Cavé, Hélène, Flotho, Christian, Hasle, Henrik, van den Heuvel-Eibrink, Marry M, Niemeyer, Charlotte, Stary, Jan, Van Roy, Nadine, Van Vlierberghe, Pieter, Philippé, Jan, De Moerloose, Barbara

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Epigenetic silencing of AKAP12 in juvenile myelomonocytic leukemia by Wilhelm, Thomas, Lipka, Daniel B, Witte, Tania, Wierzbinska, Justyna A, Fluhr, Silvia, Helf, Monika, Mücke, Oliver, Claus, Rainer, Konermann, Carolin, Nöllke, Peter, Niemeyer, Charlotte M, Flotho, Christian, Plass, Christoph

“…A-kinase anchor protein 12 (AKAP12) is a regulator of protein kinase A and protein kinase C signaling, acting downstream of RAS. Epigenetic silencing of AKAP12…”
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Hypersensitivity Reactions to Native E. coli L‐asparaginase in Children With Acute Lymphoblastic Leukemia Treated in Trial ALL‐BFM 2000: Impact of Treatment Schedule and Type of Glucocorticoid in Induction by Möricke, Anja, Rizzari, Carmelo, Alten, Julia, Attarbaschi, Andishe, Beier, Rita, Biondi, Andrea, Burkhardt, Birgit, Bodmer, Nicole, Boos, Joachim, Cario, Gunnar, Conter, Valentino, Flotho, Christian, Kulozik, Andreas, Lanvers‐Kaminsky, Claudia, Mann, Georg, Niggli, Felix, Silvestri, Daniela, Stackelberg, Arend, Stanulla, Martin, Valsecchi, Maria‐Grazia, Schrappe, Martin, Zimmermann, Martin

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Tracing the development of acute myeloid leukemia in CBL syndrome by Becker, Heiko, Yoshida, Kenichi, Blagitko-Dorfs, Nadja, Claus, Rainer, Pantic, Milena, Abdelkarim, Mahmoud, Niemöller, Christoph, Greil, Christine, Hackanson, Björn, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Miyano, Satoru, Döhner, Konstanze, Schnittger, Susanne, Henneke, Philipp, Niemeyer, Charlotte M., Flotho, Christian, Pfeifer, Dietmar, Ogawa, Seishi, Lübbert, Michael

“…We describe the development of acute myeloid leukemia (AML) in an adult with CBL syndrome caused by a heterozygous de novo germline mutation in CBL codon D390…”
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