Search Results - "Christian Dölle"

The NAD metabolome — a key determinant of cancer cell biology by Chiarugi, Alberto, Dölle, Christian, Felici, Roberta, Ziegler, Mathias

“…Key Points NAD is an important redox factor and substrate in various signalling processes, in which it is irreversibly degraded to form molecules that are of…”
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Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation by Nikiforov, Andrey, Dölle, Christian, Niere, Marc, Ziegler, Mathias

“…NAD is a vital redox carrier, and its degradation is a key element of important regulatory pathways. NAD-mediated functions are compartmentalized and have to…”
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The power to reduce: pyridine nucleotides--small molecules with a multitude of functions by Pollak, Nadine, Dölle, Christian, Ziegler, Mathias

“…The pyridine nucleotides NAD and NADP play vital roles in metabolic conversions as signal transducers and in cellular defence systems. Both coenzymes…”
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ADP‐ribosylation of DNA moving into focus by Dölle, Christian, Ziegler, Mathias

“…In this issue of The FEBS Journal, Munnur and Ahel describe the reversible mono‐ADP‐ribosylation of DNA by PARP3, a member of the poly‐ADP‐ribose‐polymerase…”
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Poly-ADP-ribose assisted protein localization resolves that DJ-1, but not LRRK2 or α-synuclein, is localized to the mitochondrial matrix by Osuagwu, Nelson, Dölle, Christian, Tzoulis, Charalampos

“…Several proteins linked to familial Parkinson disease have been associated with mitochondrial (dys-)function and have been described to reside within…”
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NAD and ADP‐ribose metabolism in mitochondria by Dölle, Christian, Rack, Johannes G.M., Ziegler, Mathias

“…Mitochondrial metabolism is intimately connected to the universal coenzyme NAD. In addition to its role in redox reactions of energy transduction, NAD serves…”
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Regulation of SIRT2-dependent α-tubulin deacetylation by cellular NAD levels by Skoge, Renate Hvidsten, Dölle, Christian, Ziegler, Mathias

“…Acetylation of α-tubulin on lysine 40 is one of the major posttranslational modifications of microtubules. The acetylation reaction is catalyzed by…”
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Brain Proteome Profiling Reveals Common and Divergent Signatures in Parkinson's Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy by Dick, Fiona, Johanson, Gard Aasmund Skulstad, Tysnes, Ole-Bjørn, Alves, Guido, Dölle, Christian, Tzoulis, Charalampos

“…The molecular pathogenesis of degenerative parkinsonisms, including Parkinson's disease (PD), progressive supranuclear palsy (PSP), and Multiple system atrophy…”
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ADP-ribosylhydrolase 3 (ARH3), Not Poly(ADP-ribose) Glycohydrolase (PARG) Isoforms, Is Responsible for Degradation of Mitochondrial Matrix-associated Poly(ADP-ribose) by Niere, Marc, Mashimo, Masato, Agledal, Line, Dölle, Christian, Kasamatsu, Atsushi, Kato, Jiro, Moss, Joel, Ziegler, Mathias

“…Important cellular processes are regulated by poly(ADP-ribosyl)ation. This protein modification is catalyzed mainly by nuclear poly(ADP-ribose) polymerase…”
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Visualization of subcellular NAD pools and intra-organellar protein localization by poly-ADP-ribose formation by Dölle, Christian, Niere, Marc, Lohndal, Emilia, Ziegler, Mathias

“…Poly-ADP-ribose polymerases (PARPs) use NAD + as substrate to generate polymers of ADP-ribose. We targeted the catalytic domain of human PARP1 as molecular NAD…”
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3,3′-Diaminobenzidine staining interferes with PCR-based DNA analysis by Dölle, Christian, Bindoff, Laurence A., Tzoulis, Charalampos

“…3,3′-Diaminobenzidine (DAB) is a widely used chromogen in histological staining methods and stained tissue is often used in downstream molecular analyses such…”
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NR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson’s disease by Berven, Haakon, Kverneng, Simon, Sheard, Erika, Søgnen, Mona, Af Geijerstam, Solveig Amdahl, Haugarvoll, Kristoffer, Skeie, Geir-Olve, Dölle, Christian, Tzoulis, Charalampos

“…Nicotinamide adenine dinucleotide (NAD) replenishment therapy using nicotinamide riboside (NR) shows promise for Parkinson’s disease (PD) and other…”
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Mitochondrial complex I deficiency stratifies idiopathic Parkinson’s disease by Flønes, Irene H., Toker, Lilah, Sandnes, Dagny Ann, Castelli, Martina, Mostafavi, Sepideh, Lura, Njål, Shadad, Omnia, Fernandez-Vizarra, Erika, Painous, Cèlia, Pérez-Soriano, Alexandra, Compta, Yaroslau, Molina-Porcel, Laura, Alves, Guido, Tysnes, Ole-Bjørn, Dölle, Christian, Nido, Gonzalo S., Tzoulis, Charalampos

“…Idiopathic Parkinson’s disease (iPD) is believed to have a heterogeneous pathophysiology, but molecular disease subtypes have not been identified. Here, we…”
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Compartment-Specific Poly-ADP-Ribose Formation as a Biosensor for Subcellular NAD Pools by VanLinden, Magali R, Niere, Marc, Nikiforov, Andrey A, Ziegler, Mathias, Dölle, Christian

“…Nicotinamide adenine dinucleotide (NAD) is vital to many cellular processes and is distributed between distinct subcellular pools in the compartmentalized…”
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Application of a coupled enzyme assay to characterize nicotinamide riboside kinases by Dölle, Christian, Ziegler, Mathias

“…The recently identified nicotinamide riboside kinases (Nrks) constitute a distinct pathway of nicotinamide adenine dinucleotide (NAD) biosynthesis. Here we…”
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Agile-waterfall hybrid product development in the manufacturing industry - Introducing guidelines for implementation of parallel use of the two models by Schuh, Gunther, Rebentisch, Eric, Riesener, Michael, Diels, Frederic, Dolle, Christian, Eich, Steffen

“…Agile development methods received a lot of attention throughout research and industry in recent years. Hybrid agile-waterfall models become increasingly…”
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Nicotinamide riboside supplementation is not associated with altered methylation homeostasis in Parkinson’s disease by Gaare, Johannes J., Dölle, Christian, Brakedal, Brage, Brügger, Kim, Haugarvoll, Kristoffer, Nido, Gonzalo S., Tzoulis, Charalampos

“…Replenishing nicotinamide adenine dinucleotide (NAD) via supplementation of nicotinamide riboside (NR) has been shown to confer neuroprotective effects in…”
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Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells by Nikiforov, Andrey, Dölle, Christian, Niere, Marc, Ziegler, Mathias

“…NAD is a vital redox carrier, and its degradation is a key element of important regulatory pathways. NAD-mediated functions are compartmentalized and have to…”
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Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease by Dölle, Christian, Flønes, Irene, Nido, Gonzalo S., Miletic, Hrvoje, Osuagwu, Nelson, Kristoffersen, Stine, Lilleng, Peer K., Larsen, Jan Petter, Tysnes, Ole-Bjørn, Haugarvoll, Kristoffer, Bindoff, Laurence A., Tzoulis, Charalampos

“…Increased somatic mitochondrial DNA (mtDNA) mutagenesis causes premature aging in mice, and mtDNA damage accumulates in the human brain with aging and…”
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The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease by Brakedal, Brage, Dölle, Christian, Riemer, Frank, Ma, Yilong, Nido, Gonzalo S., Skeie, Geir Olve, Craven, Alexander R., Schwarzlmüller, Thomas, Brekke, Njål, Diab, Joseph, Sverkeli, Lars, Skjeie, Vivian, Varhaug, Kristin, Tysnes, Ole-Bjørn, Peng, Shichun, Haugarvoll, Kristoffer, Ziegler, Mathias, Grüner, Renate, Eidelberg, David, Tzoulis, Charalampos

“…We conducted a double-blinded phase I clinical trial to establish whether nicotinamide adenine dinucleotide (NAD) replenishment therapy, via oral intake of…”
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