Search Results - "Christian Boitard"

Environmental Triggering of Type 1 Diabetes Autoimmunity by Houeiss, Pamela, Luce, Sandrine, Boitard, Christian

“…Type 1 diabetes (T1D) is a chronic autoimmune disease in which pancreatic islet β cells are destroyed by immune cells, ultimately leading to overt diabetes…”
Get full text

Preclinical Models to Evaluate the Human Response to Autoantigen and Antigen-Specific Immunotherapy in Human Type 1 Diabetes by Houeiss, Pamela, Boitard, Christian, Luce, Sandrine

“…Type 1 Diabetes (T1D) is an autoimmune disease that results from the destruction of pancreatic islet β-cells by auto-reactive T cells. The clinical management…”
Get full text

IFNγ causes mitochondrial dysfunction and oxidative stress in myositis by Abad, Catalina, Pinal-Fernandez, Iago, Guillou, Clement, Bourdenet, Gwladys, Drouot, Laurent, Cosette, Pascal, Giannini, Margherita, Debrut, Lea, Jean, Laetitia, Bernard, Sophie, Genty, Damien, Zoubairi, Rachid, Remy-Jouet, Isabelle, Geny, Bernard, Boitard, Christian, Mammen, Andrew, Meyer, Alain, Boyer, Olivier

“…Idiopathic inflammatory myopathies (IIMs) are severe autoimmune diseases with poorly understood pathogenesis and unmet medical needs. Here, we examine the role…”
Get full text

First-in-human, double-blind, randomized phase 1b study of peptide immunotherapy IMCY-0098 in new-onset type 1 diabetes: an exploratory analysis of immune biomarkers by Van Rampelbergh, Jean, Achenbach, Peter, Leslie, Richard David, Kindermans, Martin, Parmentier, Frédéric, Carlier, Vincent, Bovy, Nicolas, Vanderelst, Luc, Van Mechelen, Marcelle, Vandepapelière, Pierre, Boitard, Christian

“…IMCY-0098, a synthetic peptide developed to halt disease progression via elimination of key immune cells in the autoimmune cascade, has shown a promising…”
Get full text

A Humanized Mouse Model to Study Type 1 Diabetes by Luce, Sandrine, Guinoiseau, Sophie, Gadault, Alexis, Letourneur, Franck, Blondeau, Bertrand, Nitschke, Patrick, Pasmant, Eric, Vidaud, Michel, Lemonnier, François, Boitard, Christian

“…Key requirements in type 1 diabetes are in setting up new assays as diagnostic biomarkers that will apply to prediabetes, likely T-lymphocyte assays, and in…”
Get full text

First-in-human, double-blind, randomized phase 1b study of peptide immunotherapy IMCY-0098 in new-onset type 1 diabetes by Van Rampelbergh, Jean, Achenbach, Peter, Leslie, Richard David, Ali, Mohammad Alhadj, Dayan, Colin, Keymeulen, Bart, Owen, Katharine R, Kindermans, Martin, Parmentier, Frédéric, Carlier, Vincent, Ahangarani, Roxana R, Gebruers, Evelien, Bovy, Nicolas, Vanderelst, Luc, Van Mechelen, Marcelle, Vandepapelière, Pierre, Boitard, Christian

“…Type 1 diabetes (T1D) is a CD4 T cell-driven autoimmune disease characterized by the destruction of insulin-producing pancreatic β-cells by CD8 T cells…”
Get full text

A Humanized Mouse Strain That Develops Spontaneously Immune-Mediated Diabetes by Luce, Sandrine, Guinoiseau, Sophie, Gadault, Alexis, Letourneur, Franck, Nitschke, Patrick, Bras, Marc, Vidaud, Michel, Charneau, Pierre, Larger, Etienne, Colli, Maikel L, Eizirik, Decio L, Lemonnier, François, Boitard, Christian

“…To circumvent the limitations of available preclinical models for the study of type 1 diabetes (T1D), we developed a new humanized model, the YES-RIP-hB7.1…”
Get full text

Potential role of IL-17-producing iNKT cells in type 1 diabetes by Li, Shamin, Joseph, Claudine, Becourt, Chantal, Klibi, Jihene, Luce, Sandrine, Dubois-Laforgue, Daniele, Larger, Etienne, Boitard, Christian, Benlagha, Kamel

“…We explored in this study the status and potential role of IL-17-producing iNKT cells (iNKT17) in type 1 diabetes (T1D) by analyzing these cells in patients…”
Get full text

Microglial changes occur without neural cell death in diabetic retinopathy by Gaucher, David, Chiappore, Jean-Armand, Pâques, Michel, Simonutti, Manuel, Boitard, Christian, Sahel, José A., Massin, Pascale, Picaud, Serge

“…Very early neuroglial changes have been observed to precede major vascular changes in the retina of diabetic patients and animal models. We investigated the…”
Get full text

CD4(+) type II NKT cells mediate ICOS and programmed death-1-dependent regulation of type 1 diabetes by Kadri, Nadir, Korpos, Eva, Gupta, Shashank, Briet, Claire, Löfbom, Linda, Yagita, Hideo, Lehuen, Agnes, Boitard, Christian, Holmberg, Dan, Sorokin, Lydia, Cardell, Susanna L

“…Type 1 diabetes (T1D) is a chronic autoimmune disease that results from T cell-mediated destruction of pancreatic β cells. CD1d-restricted NKT lymphocytes have…”
Get full text

Antigen-Based Immune Therapeutics for Type 1 Diabetes : Magic Bullets or Ordinary Blanks? by Culina, Slobodan, Mallone, Roberto, Boitard, Christian

“…The ideal drug of modern medicine is the one that achieves its therapeutic target with minimal adverse effects. Immune therapy of Type 1 diabetes (T1D) is no…”
Get full text

Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice by Thébault-Baumont, Karine, Dubois-Laforgue, Danielle, Krief, Patricia, Briand, Jean-Paul, Halbout, Philippe, Vallon-Geoffroy, Karine, Morin, Joëlle, Laloux, Véronique, Lehuen, Agnès, Carel, Jean-Claude, Jami, Jacques, Muller, Sylviane, Boitard, Christian

“…Accumulating evidence favors a role for proinsulin as a key autoantigen in diabetes. In the mouse, two proinsulin isoforms coexist. Most studies point to…”
Get full text

Recognition of a Subregion of Human Proinsulin by Class I-Restricted T Cells in Type 1 Diabetic Patients by Toma, Andréa, Haddouk, Samy, Briand, Jean-Paul, Camoin, Luc, Gahery, Hanne, Connan, Francine, Dubois-Laforgue, Danielle, Caillat-Zucman, Sophie, Guillet, Jean-Gérard, Carel, Jean-Claude, Muller, Sylviane, Choppin, Jeannine, Boitard, Christian, McDevitt, Hugh O.

“…Proinsulin is a key autoantigen in type 1 diabetes. Evidence in the mouse has underscored the importance of the insulin B chain region in autoimmunity to…”
Get full text

A simple and fast non-radioactive bridging immunoassay for insulin autoantibodies by Kikkas, Ingrid, Mallone, Roberto, Tubiana-Rufi, Nadia, Chevenne, Didier, Carel, Jean Claude, Créminon, Christophe, Volland, Hervé, Boitard, Christian, Morel, Nathalie

“…Type 1 diabetes (T1D) is an autoimmune disease which results from the destruction of pancreatic beta cells. Autoantibodies directed against islet antigens are…”
Get full text

Recognition of Human Proinsulin Leader Sequence by Class I–Restricted T-Cells in HLA-A0201 Transgenic Mice and in Human Type 1 Diabetes by TOMA, Andréa, LAÏKA, Taghrid, MULLER, Sylviane, CHOPPIN, Jeannine, LEMONNIER, Francois, BOITARD, Christian, HADDOUK, Samy, LUCE, Sandrine, BRIAND, Jean-Paul, CAMOIN, Luc, CONNAN, Francine, LAMBERT, Marion, CAILLAT-ZUCMAN, Sophie, CAREL, Jean-Claude

“…Recognition of Human Proinsulin Leader Sequence by Class I–Restricted T-Cells in HLA-A*0201 Transgenic Mice and in Human Type 1 Diabetes Andréa Toma 1 ,…”
Get full text

Role of β-Cells in Type 1 Diabetes Pathogenesis by FAIDEAU, Beatrice, LARGER, Etienne, LEPAULT, Francoise, CAREL, Jean Claude, BOITARD, Christian

“…Role of β-Cells in Type 1 Diabetes Pathogenesis Béatrice Faideau , Etienne Larger , Françoise Lepault , Jean Claude Carel and Christian Boitard From the INSERM…”
Get full text

Hyperparathyroidism in a Patient with Autoimmune Polyglandular Syndrome by Pelletier-Morel, Lorraine, Fabien, Nicole, Mouhoub, Yamina, Boitard, Christian, Larger, Etienne

“…Autoimmune hypercalcemia has been reported in only a few cases, and never in the context of autoimmune polyglandular syndrome. A patient with type 1,…”
Get full text

Pancreatic islet autoimmunity by Boitard, Christian

“…Type 1 diabetes (T1D) represents 10 to 15% of all forms of diabetes. Its incidence shows a consistent rise in all countries under survey. Evidence for…”
Get full text

Three Loci on Mouse Chromosome 6 Influence Onset and Final Incidence of Type I Diabetes in NOD.C3H Congenic Strains by Rogner, Ute C., Boitard, Christian, Morin, Joelle, Melanitou, Evie, Avner, Philip

“…The development of insulin-dependent diabetes mellitus in both human and mouse is dependent on the interaction between genetic and environmental factors. The…”
Get full text

The Diabetes Type 1 Locus Idd6 Modulates Activity of CD4+CD25+ Regulatory T-Cells by ROGNER, Ute Christine, LEPAULT, Francoise, GAGNERAULT, Marie-Claude, VALLOIS, David, MORIN, Joëlle, AVNER, Philip, BOITARD, Christian

“…The Diabetes Type 1 Locus Idd6 Modulates Activity of CD4 + CD25 + Regulatory T-Cells Ute Christine Rogner 1 , Françoise Lepault 2 , Marie-Claude Gagnerault 2 ,…”
Get full text