Search Results - "Christian, K M"
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Recovery of genomes from metagenomes via a dereplication, aggregation and scoring strategy
Published in Nature microbiology (01-07-2018)“…Microbial communities are critical to ecosystem function. A key objective of metagenomic studies is to analyse organism-specific metabolic pathways and…”
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Interplay between pathway-specific and global regulation of the fumonisin gene cluster in the rice pathogen Fusarium fujikuroi
Published in Applied microbiology and biotechnology (01-07-2016)“…The rice pathogenic fungus Fusarium fujikuroi is known to produce a large variety of secondary metabolites. Besides the gibberellins, causing the bakanae…”
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The Fusarium graminearum genome reveals more secondary metabolite gene clusters and hints of horizontal gene transfer
Published in PloS one (15-10-2014)“…Fungal secondary metabolite biosynthesis genes are of major interest due to the pharmacological properties of their products (like mycotoxins and antibiotics)…”
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Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites
Published in PLoS pathogens (01-06-2013)“…The fungus Fusarium fujikuroi causes "bakanae" disease of rice due to its ability to produce gibberellins (GAs), but it is also known for producing harmful…”
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Apicidin F: characterization and genetic manipulation of a new secondary metabolite gene cluster in the rice pathogen Fusarium fujikuroi
Published in PloS one (24-07-2014)“…The fungus F. fujikuroi is well known for its production of gibberellins causing the 'bakanae' disease of rice. Besides these plant hormones, it is able to…”
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Increased circulating butyrate and ursodeoxycholate during probiotic intervention in humans with type 2 diabetes
Published in BMC microbiology (08-01-2022)“…An increasing body of evidence implicates the resident gut microbiota as playing a critical role in type 2 diabetes (T2D) pathogenesis. We previously reported…”
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Wide diversity of methane and short-chain alkane metabolisms in uncultured archaea
Published in Nature microbiology (01-04-2019)“…Methanogenesis is an ancient metabolism of key ecological relevance, with direct impact on the evolution of Earth’s climate. Recent results suggest that the…”
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Comparative genomics of geographically distant Fusarium fujikuroi isolates revealed two distinct pathotypes correlating with secondary metabolite profiles
Published in PLoS pathogens (26-10-2017)“…Fusarium fujikuroi causes bakanae ("foolish seedling") disease of rice which is characterized by hyper-elongation of seedlings resulting from production of…”
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Comparative transcriptome and proteome analysis reveals a global impact of the nitrogen regulators AreA and AreB on secondary metabolism in Fusarium fujikuroi
Published in PloS one (25-04-2017)“…The biosynthesis of multiple secondary metabolites in the phytopathogenic ascomycete Fusarium fujikuroi is strongly affected by nitrogen availability. Here, we…”
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Globally distributed root endophyte Phialocephala subalpina links pathogenic and saprophytic lifestyles
Published in BMC genomics (09-12-2016)“…Whereas an increasing number of pathogenic and mutualistic ascomycetous species were sequenced in the past decade, species showing a seemingly neutral…”
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Differential depth distribution of microbial function and putative symbionts through sediment-hosted aquifers in the deep terrestrial subsurface
Published in Nature microbiology (01-03-2018)“…An enormous diversity of previously unknown bacteria and archaea has been discovered recently, yet their functional capacities and distributions in the…”
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Two separate key enzymes and two pathway‐specific transcription factors are involved in fusaric acid biosynthesis in Fusarium fujikuroi
Published in Environmental microbiology (01-03-2016)“…Fusaric acid (FSA) is a mycotoxin produced by several fusaria, including the rice pathogen Fusarium fujikuroi. Genes involved in FSA biosynthesis were…”
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Unusual Metabolism and Hypervariation in the Genome of a Gracilibacterium (BD1-5) from an Oil-Degrading Community
Published in mBio (12-11-2019)“…The candidate phyla radiation (CPR) comprises a large monophyletic group of bacterial lineages known almost exclusively based on genomes obtained using…”
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Chronic stress-induced hippocampal dendritic retraction requires CA3 NMDA receptors
Published in Neuroscience (03-02-2011)“…Abstract Chronic stress induces dendritic retraction in the hippocampal CA3 subregion, but the mechanisms responsible for this retraction and its impact on…”
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FiberGrowth Pipeline: A Framework Toward Predicting Fiber-Specific Growth From Human Gut Bacteroidetes Genomes
Published in Frontiers in microbiology (06-10-2021)“…Dietary fibers impact gut colonic health, through the production of short-chain fatty acids. A low-fiber diet has been linked to lower bacterial diversity,…”
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The GATA-Type Transcription Factor Csm1 Regulates Conidiation and Secondary Metabolism in Fusarium fujikuroi
Published in Frontiers in microbiology (26-06-2017)“…GATA-type transcription factors (TFs) such as the nitrogen regulators AreA and AreB, or the light-responsive TFs WC-1 and WC-2, play global roles in fungal…”
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Secreted frizzled-related protein 3 (sFRP3) regulates antidepressant responses in mice and humans
Published in Molecular psychiatry (01-09-2013)Get full text
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Identification of recurrent c.742G>T nonsense mutation in ECM1 in Pakistani families suffering from lipoid proteinosis
Published in Molecular biology reports (2014)“…Lipoid proteinosis (LP) is one of the rare, recessive autosomal disorders clinically characterized by widespread deposition of hyaline-like material in the…”
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Simulation of Deepwater Horizon oil plume reveals substrate specialization within a complex community of hydrocarbon degraders
Published in Proceedings of the National Academy of Sciences - PNAS (11-07-2017)“…The Deepwater Horizon (DWH) accident released an estimated 4.1 million barrels of oil and 1010 mol of natural gas into the Gulf of Mexico, forming deep-sea…”
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Elucidation of the Two H3K36me3 Histone Methyltransferases Set2 and Ash1 in Fusarium fujikuroi Unravels Their Different Chromosomal Targets and a Major Impact of Ash1 on Genome Stability
Published in Genetics (Austin) (01-01-2018)“…In this work, we present a comprehensive analysis of the H3K36 histone methyltransferases Set2 and Ash1 in the filamentous ascomycete In , one single…”
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