Search Results - "Christian, J.M."
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The Glove-like Structure of the Conserved Membrane Protein TatC Provides Insight into Signal Sequence Recognition in Twin-Arginine Translocation
Published in Structure (London) (07-05-2013)“…In bacteria, two signal-sequence-dependent secretion pathways translocate proteins across the cytoplasmic membrane. Although the mechanism of the ubiquitous…”
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Model for eukaryotic tail-anchored protein binding based on the structure of Get3
Published in Proceedings of the National Academy of Sciences - PNAS (01-09-2009)“…The Get3 ATPase directs the delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER). TA-proteins are characterized by having a single…”
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Characterization of the various forms of the Reelin protein in the cerebrospinal fluid of normal subjects and in neurological diseases
Published in Neurobiology of disease (01-03-2004)“…Reelin is a large extracellular glycoprotein that is defective in reeler mutant mice and plays a well-established role during brain development in human as…”
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Families of exact similaritons with flexible modulations in N-coupled homogeneous and inhomogeneous systems
Published in Physics letters. A (15-12-2024)“…•A family of exact solutions are derived for N-CNLS under the constraints of amplitude and coupling coefficients.•The bright solutions with the constraints can…”
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Usability testing: a review of some methodological and technical aspects of the method
Published in International journal of medical informatics (Shannon, Ireland) (01-04-2010)“…Abstract The aim of this paper is to review some work conducted in the field of user testing that aims at specifying or clarifying the test procedures and at…”
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Spontaneous coronary artery dissection
Published in Heart (British Cardiac Society) (01-05-2010)Get more information
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The effect of coherent coupling nonlinearity on modulation instability and rogue wave excitation
Published in Communications in nonlinear science & numerical simulation (01-05-2022)“…We study modulation instability (MI) in both anomalous and normal dispersion regimes of a coherently coupled system. It is found that there exist three types…”
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A mathematical model for the motion of a micro-robot consisting of three spheres linked with axially aligned retractable arms in Stokes flow that gives expressions for mean distance moved, mean drift velocity and energy efficiency of the non-reciprocal cyclic swimming motion
Published in Computers & fluids (15-11-2023)“…The problem studied was the non-reciprocal cyclic swimming motion of three spheres linked with axially aligned retractable arms in Stokes flow. The arms are…”
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Ultrashort nonautonomous similariton solutions and the cascade tunneling of interacting similaritons
Published in Optics communications (15-03-2020)“…Similarity transformation and Hirota bilinearization are deployed to derive exact bright and dark ultrashort one- and two-similariton solutions of a…”
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B7-1 (CD80), B7-2 (CD86), interleukin-12 and transforming growth factor-β mRNA expression in CSF and peripheral blood mononuclear cells from multiple sclerosis patients
Published in Journal of neuroimmunology (02-11-1998)“…Costimulatory molecules B7-1 (CD80) and B7-2 (CD86) are differently involved in T cell stimulation. In chronic experimental autoimmune encephalomyelitis (EAE)…”
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Cytokine mRNA expression in CSF and peripheral blood mononuclear cells in multiple sclerosis: detection by RT-PCR without in vitro stimulation
Published in Journal of neuroimmunology (01-12-1997)“…We amplified the mRNA for cytokines in peripheral blood mononuclear cells (PBMC) and cerebrospinal fluid (CSF) cells from 18 multiple sclerosis (MS) patients…”
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Características clínicas, pronóstico y evolución de los pacientes con VIH y trasplante cardíaco
Published in Cirugía cardiovascular (01-01-2018)Get full text
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Fingolimod increases CD39-expressing regulatory T cells in multiple sclerosis patients
Published in PloS one (20-11-2014)“…Multiple sclerosis (MS) likely results from an imbalance between regulatory and inflammatory immune processes. CD39 is an ectoenzyme that cleaves ATP to AMP…”
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Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway
Published in Cell death and differentiation (01-06-2017)“…Keratins (K) are intermediate filament proteins important in stress protection and mechanical support of epithelial tissues. K8, K18 and K19 are the main…”
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Sumoylation of Notch1 represses its target gene expression during cell stress
Published in Cell death and differentiation (01-03-2018)“…The Notch signaling pathway is a key regulator of stem cells during development, and its deregulated activity is linked to developmental defects and cancer…”
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Infectious neuropathies
Published in Current opinion in neurology (01-10-2013)“…Infectious neuropathies are heterogeneous neuropathies with multiple causes. They still represent an important world health burden and some of them have no…”
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The complex process of GETting tail-anchored membrane proteins to the ER
Published in Current opinion in structural biology (01-04-2012)“…► Get3 is a central nucleotide hydrolase in the GET pathway, and models for interaction of tail-anchored (TA) proteins with Get3 include a binding groove…”
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Structural characterization of the Get4/Get5 complex and its interaction with Get3
Published in Proceedings of the National Academy of Sciences - PNAS (06-07-2010)“…The recently elucidated Get proteins are responsible for the targeted delivery of the majority of tail-anchored (TA) proteins to the endoplasmic reticulum…”
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Regulation of Treg-associated CD39 in multiple sclerosis and effects of corticotherapy during relapse
Published in Multiple sclerosis (01-10-2015)“…Background: Accumulating data highlight proinflammatory processes leading to MS relapses. Whether anti-inflammatory mechanisms are concomitantly activated is…”
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