Search Results - "Christian, Hartinger"

Biodistribution of the novel anticancer drug sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] KP-1339/IT139 in nude BALB/c mice and implications on its mode of action by Bytzek, Anna K., Koellensperger, Gunda, Keppler, Bernhard K., G. Hartinger, Christian

“…The ruthenium complex sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] (KP-1339/IT139) has entered clinical trials as the more soluble alternative to…”
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Anticancer metallodrugs: where is the next cisplatin? by Hanif, Muhammad, Hartinger, Christian G

“…Despite the severe side effects and the emergence of drug resistance, the use of DNA-targeting platinum drugs remains strong either alone or in a combination…”
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Bioorganometallic chemistry--from teaching paradigms to medicinal applications by Hartinger, Christian G, Dyson, Paul J

“…In undergraduate level organometallic chemistry courses students are usually taught that organometallic compounds are toxic and unstable in air and water…”
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Development of anticancer agents: wizardry with osmium by Hanif, Muhammad, Babak, Maria V., Hartinger, Christian G.

“…•Osmium complexes are promising anticancer agents.•In vitro assays revealed antiproliferative activity in nanomolar concentrations.•New leads of osmium are…”
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Anticancer activity of metal complexes: involvement of redox processes by Jungwirth, Ute, Kowol, Christian R, Keppler, Bernhard K, Hartinger, Christian G, Berger, Walter, Heffeter, Petra

“…Cells require tight regulation of the intracellular redox balance and consequently of reactive oxygen species for proper redox signaling and maintenance of…”
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Zwitterionic Polyelectrolyte Complex Vesicles Assembled from Homopoly(2-Oxazoline)s as Enzyme Catalytic Nanoreactors for Potent Anti-Tumor Efficiency by Wang, Hepeng, Zhang, Guojing, Lin, Min, Hartinger, Christian G., Sun, Jing

“…Enzymes are known for their remarkable catalytic efficiency across a wide range of applications. Here, we present a novel and convenient nanoreactor platform…”
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Impact of the Halogen Substitution Pattern on the Biological Activity of Organoruthenium 8‑Hydroxyquinoline Anticancer Agents by Kubanik, Mario, Holtkamp, Hannah, Söhnel, Tilo, Jamieson, Stephen M. F, Hartinger, Christian G

“…8-Hydroxyquinoline and its derivatives have a broad variety of pharmacological properties, which make them an ideal bioactive building block in the development…”
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From Catalysis to Cancer: Toward Structure–Activity Relationships for Benzimidazol-2-ylidene-Derived N‑Heterocyclic-Carbene Complexes as Anticancer Agents by Lam, Nelson Y. S, Truong, Dianna, Burmeister, Hilke, Babak, Maria V, Holtkamp, Hannah U, Movassaghi, Sanam, Ayine-Tora, Daniel Moscoh, Zafar, Ayesha, Kubanik, Mario, Oehninger, Luciano, Söhnel, Tilo, Reynisson, Jóhannes, Jamieson, Stephen M. F, Gaiddon, Christian, Ott, Ingo, Hartinger, Christian G

“…The promise of the metal­(arene) structure as an anticancer pharmacophore has prompted intensive exploration of this chemical space. While N-heterocyclic…”
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Heterotrimetallic Double Cavity Cages: Syntheses and Selective Guest Binding by Lisboa, Lynn S., Preston, Dan, McAdam, C. John, Wright, L. James, Hartinger, Christian G., Crowley, James D.

“…A strategy for the generation of heterotrimetallic double cavity (DC) cages [PdnPtmL4]6+ (DC1: n=1, m=2; and DC2: n=2, m=1) is reported. The DC cages were…”
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Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs by Hartinger, Christian G, Groessl, Michael, Meier, Samuel M, Casini, Angela, Dyson, Paul J

“…Mass spectrometry (MS) has emerged as an important tool for studying anticancer metallodrugs in complex biological samples and for characterising their…”
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Determination of Relative Stabilities of Metal‐Peptide Bonds in the Gas Phase by Cziferszky, Monika, Truong, Dianna, Hartinger, Christian G., Gust, Ronald

“…Understanding binding site preferences in biological systems as well as affinities to binding partners is a crucial aspect in metallodrug development. We here…”
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KP1019, A New Redox-Active Anticancer Agent - Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients by Hartinger, Christian G., Jakupec, Michael A., Zorbas-Seifried, Stefanie, Groessl, Michael, Egger, Alexander, Berger, Walter, Zorbas, Haralabos, Dyson, Paul J., Keppler, Bernhard K.

“…The promising drug candidate indazolium trans‐[tetrachlorobis(1H‐indazole)ruthenate(III)] (KP1019) is the second Ru‐based anticancer agent to enter clinical…”
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Electrophoretic separation techniques and their hyphenation to mass spectrometry in biological inorganic chemistry by Holtkamp, Hannah, Grabmann, Gerlinde, Hartinger, Christian G.

“…Electrophoretic methods have been widely applied in research on the roles of metal complexes in biological systems. In particular, CE, often hyphenated to a…”
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An Organoruthenium Anticancer Agent Shows Unexpected Target Selectivity For Plectin by Meier, Samuel M., Kreutz, Dominique, Winter, Lilli, Klose, Matthias H. M., Cseh, Klaudia, Weiss, Tamara, Bileck, Andrea, Alte, Beatrix, Mader, Johanna C., Jana, Samir, Chatterjee, Annesha, Bhattacharyya, Arindam, Hejl, Michaela, Jakupec, Michael A., Heffeter, Petra, Berger, Walter, Hartinger, Christian G., Keppler, Bernhard K., Wiche, Gerhard, Gerner, Christopher

“…Organometallic metal(arene) anticancer agents require ligand exchange for their anticancer activity and this is generally believed to confer low selectivity…”
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Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action by Babak, Maria V, Pfaffeneder-Kmen, Martin, Meier-Menches, Samuel M, Legina, Maria S, Theiner, Sarah, Licona, Cynthia, Orvain, Christophe, Hejl, Michaela, Hanif, Muhammad, Jakupec, Michael A, Keppler, Bernhard K, Gaiddon, Christian, Hartinger, Christian G

“…Platinum-based anticancer coordination compounds are widely used in the treatment of many tumor types, where they are very effective but also cause severe side…”
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Anticancer metallodrug research analytically painting the “omics” picture—current developments and future trends by Groessl, Michael, Hartinger, Christian G.

“…Anticancer metallodrug development has for a long time been characterised by the similarity of new drug candidates to cisplatin and DNA as the primary target…”
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AsBIC8 –8th Asia/Pacific Biological Inorganic Chemistry Conference by Hartinger, Christian G.

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Polynuclear ruthenium, osmium and gold complexes. The quest for innovative anticancer chemotherapeutics by Hartinger, Christian G, Phillips, Andrew D, Nazarov, Alexey A

“…Polynuclear compounds are a relatively new and successful approach in metal-based cancer chemotherapy as typified by the trinuclear Pt compound BBR3464 which…”
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Antitumour metal compounds: more than theme and variations by Jakupec, Michael A, Galanski, Markus, Arion, Vladimir B, Hartinger, Christian G, Keppler, Bernhard K

“…Triggered by the resounding success of cisplatin, the past decades have seen tremendous efforts to produce clinically beneficial analogues. The recent…”
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Not All Binding Sites Are Equal: Site Determination and Folding State Analysis of Gas‐Phase Protein‐Metallodrug Adducts by Eade, Liam, Sullivan, Matthew P., Allison, Timothy M., Goldstone, David C., Hartinger, Christian G.

“…Modern approaches in metallodrug research focus on compounds that bind protein targets rather than DNA. However, the identification of protein targets and…”
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