Search Results - "Christian, Bradley T"

Amyloid and tau imaging biomarkers explain cognitive decline from late middle-age by Betthauser, Tobey J, Koscik, Rebecca L, Jonaitis, Erin M, Allison, Samantha L, Cody, Karly A, Erickson, Claire M, Rowley, Howard A, Stone, Charles K, Mueller, Kimberly D, Clark, Lindsay R, Carlsson, Cynthia M, Chin, Nathaniel A, Asthana, Sanjay, Christian, Bradley T, Johnson, Sterling C

“…This study investigated differences in retrospective cognitive trajectories between amyloid and tau PET biomarker stratified groups in initially cognitively…”
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Autologous transplant therapy alleviates motor and depressive behaviors in parkinsonian monkeys by Tao, Yunlong, Vermilyea, Scott C., Zammit, Matthew, Lu, Jianfeng, Olsen, Miles, Metzger, Jeanette M., Yao, Lin, Chen, Yuejun, Phillips, Sean, Holden, James E., Bondarenko, Viktoriya, Block, Walter F., Barnhart, Todd E., Schultz-Darken, Nancy, Brunner, Kevin, Simmons, Heather, Christian, Bradley T., Emborg, Marina E., Zhang, Su-Chun

“…Degeneration of dopamine (DA) neurons in the midbrain underlies the pathogenesis of Parkinson’s disease (PD). Supplement of DA via L-DOPA alleviates motor…”
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A multi-scanner neuroimaging data harmonization using RAVEL and ComBat by Eshaghzadeh Torbati, Mahbaneh, Minhas, Davneet S., Ahmad, Ghasan, O’Connor, Erin E., Muschelli, John, Laymon, Charles M., Yang, Zixi, Cohen, Ann D., Aizenstein, Howard J., Klunk, William E., Christian, Bradley T., Hwang, Seong Jae, Crainiceanu, Ciprian M., Tudorascu, Dana L.

“…•RAVEL substantially improved the reproducibility of image intensities.•ComBat is preferred over RAVEL and the RAVEL-ComBat combination in terms of regional…”
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Basal Forebrain Cholinergic Neurons: Linking Down Syndrome and Alzheimer's Disease by Martinez, Jose L, Zammit, Matthew D, West, Nicole R, Christian, Bradley T, Bhattacharyya, Anita

“…Down syndrome (DS, trisomy 21) is characterized by intellectual impairment at birth and Alzheimer's disease (AD) pathology in middle age. As individuals with…”
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PET measurement of longitudinal amyloid load identifies the earliest stages of amyloid-beta accumulation during Alzheimer's disease progression in Down syndrome by Zammit, Matthew D., Tudorascu, Dana L., Laymon, Charles M., Hartley, Sigan L., Zaman, Shahid H., Ances, Beau M., Johnson, Sterling C., Stone, Charles K., Mathis, Chester A., Klunk, William E., Cohen, Ann D., Handen, Benjamin L., Christian, Bradley T.

“…Adults with Down syndrome (DS) are predisposed to Alzheimer's disease (AD) and reveal early amyloid beta (Aβ) pathology in the brain. Positron emission…”
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Cerebrovascular disease emerges with age and Alzheimer’s disease in adults with Down syndrome by Lao, Patrick, Edwards, Natalie, Flores-Aguilar, Lisi, Alshikho, Mohamad, Rizvi, Batool, Tudorascu, Dana, Rosas, H. Diana, Yassa, Michael, Christian, Bradley T., Mapstone, Mark, Handen, Benjamin, Zimmerman, Molly E., Gutierrez, Jose, Wilcock, Donna, Head, Elizabeth, Brickman, Adam M.

“…Adults with Down syndrome have a genetic form of Alzheimer’s disease (AD) and evidence of cerebrovascular disease across the AD continuum, despite few systemic…”
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Mind-body interactions in the regulation of airway inflammation in asthma: A PET study of acute and chronic stress by Rosenkranz, Melissa A, Esnault, Stephane, Christian, Bradley T, Crisafi, Gina, Gresham, Lauren K, Higgins, Andrew T, Moore, Mollie N, Moore, Sarah M, Weng, Helen Y, Salk, Rachel H, Busse, William W, Davidson, Richard J

“…Highlights • Chronic stress is associated with increased depression and anxiety and poorer asthma control. • Asthmatics with high chronic stress have an…”
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Measuring longitudinal cognition: Individual tests versus composites by Jonaitis, Erin M., Koscik, Rebecca L., Clark, Lindsay R., Ma, Yue, Betthauser, Tobey J., Berman, Sara E., Allison, Samantha L., Mueller, Kimberly D., Hermann, Bruce P., Van Hulle, Carol A., Christian, Bradley T., Bendlin, Barbara B., Blennow, Kaj, Zetterberg, Henrik, Carlsson, Cynthia M., Asthana, Sanjay, Johnson, Sterling C.

“…Longitudinal cohort studies of cognitive aging must confront several sources of within-person variability in scores. In this article, we compare several…”
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Human brain imaging of nicotinic acetylcholine α4β2 receptors using [18F]Nifene: Selectivity, functional activity, toxicity, aging effects, gender effects, and extrathalamic pathways by Mukherjee, Jogeshwar, Lao, Patrick J., Betthauser, Tobey J., Samra, Gurleen K., Pan, Min‐Liang, Patel, Ishani H., Liang, Christopher, Metherate, Raju, Christian, Bradley T.

“…Nicotinic acetylcholinergic receptors (nAChR's) have been implicated in several brain disorders, including addiction, Parkinson's disease, Alzheimer's disease…”
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Validity Evidence for the Research Category, "Cognitively Unimpaired - Declining," as a Risk Marker for Mild Cognitive Impairment and Alzheimer's Disease by Langhough Koscik, Rebecca, Hermann, Bruce P, Allison, Samantha, Clark, Lindsay R, Jonaitis, Erin M, Mueller, Kimberly D, Betthauser, Tobey J, Christian, Bradley T, Du, Lianlian, Okonkwo, Ozioma, Birdsill, Alex, Chin, Nathaniel, Gleason, Carey, Johnson, Sterling C

“…While clinically significant cognitive impairment is the key feature of the symptomatic stages of the Alzheimer's disease (AD) continuum, subtle cognitive…”
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The relationship of insulin resistance and diabetes to tau PET SUVR in middle-aged to older adults by Ennis, Gilda E, Betthauser, Tobey J, Koscik, Rebecca Langhough, Chin, Nathaniel A, Christian, Bradley T, Asthana, Sanjay, Johnson, Sterling C, Bendlin, Barbara B

“…Insulin resistance (IR) and type 2 diabetes have been found to increase the risk for Alzheimer's clinical syndrome in epidemiologic studies but have not been…”
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Amyloid duration is associated with preclinical cognitive decline and tau PET by Koscik, Rebecca L., Betthauser, Tobey J., Jonaitis, Erin M., Allison, Samantha L., Clark, Lindsay R., Hermann, Bruce P., Cody, Karly A., Engle, Jonathan W., Barnhart, Todd E., Stone, Charles K., Chin, Nathaniel A., Carlsson, Cynthia M., Asthana, Sanjay, Christian, Bradley T., Johnson, Sterling C.

“…Introduction This study applies a novel algorithm to longitudinal amyloid positron emission tomography (PET) imaging to identify age‐heterogeneous amyloid…”
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Cardiorespiratory Fitness Attenuates the Influence of Amyloid on Cognition by Schultz, Stephanie A, Boots, Elizabeth A, Almeida, Rodrigo P, Oh, Jennifer M, Einerson, Jean, Korcarz, Claudia E, Edwards, Dorothy F, Koscik, Rebecca L, Dowling, Maritza N, Gallagher, Catherine L, Bendlin, Barbara B, Christian, Bradley T, Zetterberg, Henrik, Blennow, Kaj, Carlsson, Cynthia M, Asthana, Sanjay, Hermann, Bruce P, Sager, Mark A, Johnson, Sterling C, Stein, James H, Okonkwo, Ozioma C

“…The aim of this study was to examine cross-sectionally whether higher cardiorespiratory fitness (CRF) might favorably modify amyloid-β (Aβ)-related decrements…”
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Corrigendum: Basal Forebrain Cholinergic Neurons: Linking Down Syndrome and Alzheimer's Disease by Martinez, Jose L., Zammit, Matthew D., West, Nicole R., Christian, Bradley T., Bhattacharyya, Anita

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Beta-amyloid and cognitive decline in late middle age: Findings from the Wisconsin Registry for Alzheimer's Prevention study by Clark, Lindsay R, Racine, Annie M, Koscik, Rebecca L, Okonkwo, Ozioma C, Engelman, Corinne D, Carlsson, Cynthia M, Asthana, Sanjay, Bendlin, Barbara B, Chappell, Rick, Nicholas, Christopher R, Rowley, Howard A, Oh, Jennifer M, Hermann, Bruce P, Sager, Mark A, Christian, Bradley T, Johnson, Sterling C

“…Abstract Introduction The present study investigated the relationship between beta-amyloid (Aβ) and cognition in a late middle-aged cohort at risk for…”
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Physical activity, memory function, and hippocampal volume in adults with Down syndrome by Peven, Jamie C, Handen, Benjamin L, Laymon, Charles M, Fleming, Victoria, Piro-Gambetti, Brianna, Christian, Bradley T, Klunk, William, Cohen, Ann D, Okonkwo, Ozioma, Hartley, Sigan L

“…Higher engagement in moderate-intensity physical activity (PA) is related to better cognitive functioning in neurotypical adults; however, little is known…”
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Role of tau deposition in early cognitive decline in Down syndrome by Hartley, Sigan L., Handen, Benjamin L., Tudorascu, Dana, Lee, Laise, Cohen, Annie, Piro‐Gambetti, Brianna, Zammit, Matthew, Klunk, William, Laymon, Charles, Zaman, Shahid, Ances, Beau M., Sabbagh, Marwan, Christian, Bradley T.

“…Introduction Drawing on the amyloid/tau/neurodegeneration (AT[N]) model, the study examined whether the tau positron emission tomography (PET) biomarker…”
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Associations between white matter microstructure and amyloid burden in preclinical Alzheimer's disease: A multimodal imaging investigation by Racine, Annie M, Adluru, Nagesh, Alexander, Andrew L, Christian, Bradley T, Okonkwo, Ozioma C, Oh, Jennifer, Cleary, Caitlin A, Birdsill, Alex, Hillmer, Ansel T, Murali, Dhanabalan, Barnhart, Todd E, Gallagher, Catherine L, Carlsson, Cynthia M, Rowley, Howard A, Dowling, N Maritza, Asthana, Sanjay, Sager, Mark A, Bendlin, Barbara B, Johnson, Sterling C

“…Some cognitively healthy individuals develop brain amyloid accumulation, suggestive of incipient Alzheimer's disease (AD), but the effect of amyloid on other…”
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Human biodistribution and dosimetry of [18F]nifene, an α4β2 nicotinic acetylcholine receptor PET tracer by Betthauser, Tobey J., Hillmer, Ansel T., Lao, Patrick J., Ehlerding, Emily, Mukherjee, Jogeshwar, Stone, Charles K., Christian, Bradley T.

“…The α4β2* nicotinic acetylcholine receptor (nAChR) system is implicated in many neuropsychiatric pathologies. [18F]Nifene is a positron emission tomography…”
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Cognitive indicators of transition to preclinical and prodromal stages of Alzheimer's disease in Down syndrome by Hartley, Sigan L., Handen, Benjamin L., Devenny, Darlynne, Tudorascu, Dana, Piro‐Gambetti, Brianna, Zammit, Matthew D., Laymon, Charles M., Klunk, William E., Zaman, Shahid, Cohen, Annie, Christian, Bradley T.

“…Introduction There is a critical need to identify measures of cognitive functioning sensitive to early Alzheimer's disease (AD) pathophysiology in Down…”
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