Search Results - "Christgen, Shelbi"

Toward targeting inflammasomes: insights into their regulation and activation by Christgen, Shelbi, Place, David E., Kanneganti, Thirumala-Devi

“…Inflammasomes are multi-component signaling complexes critical to the initiation of pyroptotic cell death in response to invading pathogens and cellular…”
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Role of Proline in Pathogen and Host Interactions by Christgen, Shelbi L, Becker, Donald F

“…Proline metabolism has complex roles in a variety of biological processes, including cell signaling, stress protection, and energy production. Proline also…”
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ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis by Karki, Rajendra, Sundaram, Balamurugan, Sharma, Bhesh Raj, Lee, SangJoon, Malireddi, R.K. Subbarao, Nguyen, Lam Nhat, Christgen, Shelbi, Zheng, Min, Wang, Yaqiu, Samir, Parimal, Neale, Geoffrey, Vogel, Peter, Kanneganti, Thirumala-Devi

“…Cell death provides host defense and maintains homeostasis. Zα-containing molecules are essential for these processes. Z-DNA binding protein 1 (ZBP1) activates…”
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Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis) by Christgen, Shelbi, Zheng, Min, Kesavardhana, Sannula, Karki, Rajendra, Malireddi, R K Subbarao, Banoth, Balaji, Place, David E, Briard, Benoit, Sharma, Bhesh Raj, Tuladhar, Shraddha, Samir, Parimal, Burton, Amanda, Kanneganti, Thirumala-Devi

“…Programmed cell death plays crucial roles in organismal development and host defense. Recent studies have highlighted mechanistic overlaps and extensive,…”
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Methods for determining the reduction potentials of flavin enzymes by Christgen, Shelbi L, Becker, Sophia M, Becker, Donald F

“…A key factor for flavoenzyme activity is the reduction potential of the bound flavin. The reduction potentials of protein-bound flavins span approximately a…”
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Galactosaminogalactan activates the inflammasome to provide host protection by Briard, Benoit, Fontaine, Thierry, Samir, Parimal, Place, David E., Muszkieta, Laetitia, Malireddi, R. K. Subbarao, Karki, Rajendra, Christgen, Shelbi, Bomme, Perrine, Vogel, Peter, Beau, Rémi, Mellado, Emilia, Ibrahim-Granet, Oumaima, Henrissat, Bernard, Kalathur, Ravi C., Robinson, Cam, Latgé, Jean-Paul, Kanneganti, Thirumala-Devi

“…Inflammasomes are important sentinels of innate immune defence that are activated in response to diverse stimuli, including pathogen-associated molecular…”
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Probing the function of a ligand-modulated dynamic tunnel in bifunctional proline utilization A (PutA) by Korasick, David A., Christgen, Shelbi L., Qureshi, Insaf A., Becker, Donald F., Tanner, John J.

“…In many bacteria, the reactions of proline catabolism are catalyzed by the bifunctional enzyme known as proline utilization A (PutA). PutA catalyzes the…”
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Discovery of the Membrane Binding Domain in Trifunctional Proline Utilization A by Christgen, Shelbi L, Zhu, Weidong, Sanyal, Nikhilesh, Bibi, Bushra, Tanner, John J, Becker, Donald F

“…Escherichia coli proline utilization A (EcPutA) is the archetype of trifunctional PutA flavoproteins, which function both as regulators of the proline…”
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Hierarchical Cell Death Program Disrupts the Intracellular Niche Required for Burkholderia thailandensis Pathogenesis by Place, David E, Christgen, Shelbi, Tuladhar, Shraddha, Vogel, Peter, Malireddi, R K Subbarao, Kanneganti, Thirumala-Devi

“…infections can result in serious diseases with high mortality, such as melioidosis, and they are difficult to treat with antibiotics. Innate immunity is…”
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Redox Modulation of Oligomeric State in Proline Utilization A by Korasick, David A., Campbell, Ashley C., Christgen, Shelbi L., Chakravarthy, Srinivas, White, Tommi A., Becker, Donald F., Tanner, John J.

“…Homooligomerization of proline utilization A (PutA) bifunctional flavoenzymes is intimately tied to catalytic function and substrate channeling. PutA from…”
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Inflammasomes and the fine line between defense and disease by Christgen, Shelbi, Kanneganti, Thirumala-Devi

“…•IRF proteins regulate important components of inflammasome activation.•The NLRP1b inflammasome is activated through ‘functional degradation’.•NLRP6 senses…”
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Programming inflammatory cell death for therapy by Christgen, Shelbi, Tweedell, Rebecca E., Kanneganti, Thirumala-Devi

“…Programmed cell death (PCD) is an essential part of organismal development and plays fundamental roles in host defense against pathogens and the maintenance of…”
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Sepsis take-out: Inhibiting bacterial deliveries by Christgen, Shelbi, Kanneganti, Thirumala-Devi

“…Sepsis remains a deadly disease with limited treatment options. In this issue of Immunity, Tang et al. propose that heparin provides protection during…”
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Galactosaminogalactan activates the inflammasome to provide host protection by Briard, Benoit, Fontaine, Thierry, Samir, Parimal, Place, David E, Muszkieta, Laetitia, Malireddi, R K Subbarao, Karki, Rajendra, Christgen, Shelbi, Bomme, Perrine, Vogel, Peter, Beau, Rémi, Mellado, Emilia, Ibrahim-Granet, Oumaima, Henrissat, Bernard, Kalathur, Ravi C, Robinson, Cam, Latgé, Jean-Paul, Kanneganti, Thirumala-Devi

“…Inflammasomes are important sentinels of innate immune defence that are activated in response to diverse stimuli, including pathogen-associated molecular…”
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Probing the Function of a Ligand-Modulated Dynamic Tunnel in Bi-functional Proline Utilization A (PutA) by Korasick, David A., Christgen, Shelbi L., Qureshi, Insaf A., Becker, Donald F., Tanner, John J.

“…In many bacteria, the reactions of proline catabolism are catalyzed by the bifunctional enzyme known as proline utilization A (PutA). PutA catalyzes the…”
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The IFN‐inducible GTPase IRGB10 regulates viral replication and inflammasome activation during influenza A virus infection in mice by Christgen, Shelbi, Place, David E., Zheng, Min, Briard, Benoit, Yamamoto, Masahiro, Kanneganti, Thirumala‐Devi

“…The upregulation of interferon (IFN)‐inducible GTPases in response to pathogenic insults is vital to host defense against many bacterial, fungal, and viral…”
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Exploring the Role of Proline Metabolism in Helicobacter Pathogenicity by Christgen, Shelbi, Ramer‐Tait, Amanda, Becker, Don

“…Abstract only Helicobacters have been associated with many diseases; including inflammatory bowel disease (Shomer, N et. al. 1997 Infec & Immun 65: 4858‐64)…”
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Identification of a Conserved Histidine as Critical for the Catalytic Mechanism and Functional Switching of the Multifunctional Proline Utilization A Protein by Moxley, Michael A., Zhang, Lu, Christgen, Shelbi, Tanner, John J., Becker, Donald F.

“…Proline utilization A from Escherichia coli ( Ec PutA) is a multifunctional flavoenzyme that oxidizes proline to glutamate through proline dehydrogenase…”
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Redox Modulation of Oligomeric State in Proline Utilization A by Korasick, David A., Campbell, Ashley C., Christgen, Shelbi L., Chakravarthy, Srinivas, White, Tommi A., Becker, Donald F., Tanner, John J.

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Publisher Correction: Galactosaminogalactan activates the inflammasome to provide host protection by Briard, Benoit, Fontaine, Thierry, Samir, Parimal, Place, David E., Muszkieta, Laetitia, Malireddi, R. K. Subbarao, Karki, Rajendra, Christgen, Shelbi, Bomme, Perrine, Vogel, Peter, Beau, Rémi, Mellado, Emilia, Ibrahim-Granet, Oumaima, Henrissat, Bernard, Kalathur, Ravi C., Robinson, Cam, Latgé, Jean-Paul, Kanneganti, Thirumala-Devi

“…A Correction to this paper has been published: https://doi.org/10.1038/s41586-020-03088-5…”
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