Search Results - "Christensen, Kenneth V."

Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells by Thirstrup, Kenneth, Dächsel, Justus C., Oppermann, Felix S., Williamson, Douglas S., Smith, Garrick P., Fog, Karina, Christensen, Kenneth V.

“…Genetic variation in the leucine-rich repeat kinase 2 ( LRRK2 ) gene is associated with risk of familial and sporadic Parkinson’s disease (PD). To support…”
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Persistent gating deficit and increased sensitivity to NMDA receptor antagonism after puberty in a new mouse model of the human 22q11.2 microdeletion syndrome: a study in male mice by Didriksen, Michael, PhD, Fejgin, Kim, PhD, Birknow, Michelle R., MSc, Larsen, Peter H., PhD, Lauridsen, Jes B., PhD, Nielsen, Vibeke, BSc, Kallunki, Pekka, PhD, Christensen, Kenneth V., PhD, Stensbøl, Tine B., PhD, Egebjerg, Jan, PhD, Nielsen, Jacob, PhD, Nilsson, Simon R.O., PhD, Grayton, Hannah M., PhD, Gastambide, Francois, PhD, Celada, Pau, PhD, Artigas, Francesc, PhD, Santana, Noemi, PhD, Werge, Thomas M., PhD, Bastlund, Jesper F., PhD

“…Background The hemizygous 22q11.2 microdeletion is a common copy number variant in humans. The deletion confers high risk for neurodevelopmental disorders,…”
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A mouse model of the schizophrenia-associated 1q21.1 microdeletion syndrome exhibits altered mesolimbic dopamine transmission by Nielsen, Jacob, Fejgin, Kim, Sotty, Florence, Nielsen, Vibeke, Mørk, Arne, Christoffersen, Claus T., Yavich, Leonid, Lauridsen, Jes B., Clausen, Dorte, Larsen, Peter H., Egebjerg, Jan, Werge, Thomas M., Kallunki, Pekka, Christensen, Kenneth V., Didriksen, Michael

“…1q21.1 hemizygous microdeletion is a copy number variant leading to eightfold increased risk of schizophrenia. In order to investigate biological alterations…”
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Levetiracetam attenuates hippocampal expression of synaptic plasticity-related immediate early and late response genes in amygdala-kindled rats by Christensen, Kenneth V, Leffers, Henrik, Watson, William P, Sánchez, Connie, Kallunki, Pekka, Egebjerg, Jan

“…The amygdala-kindled rat is a model for human temporal lobe epilepsy and activity-dependent synaptic plasticity. Hippocampal RNA isolated from amygdala-kindled…”
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Design and Synthesis of Pyrrolo[2,3‑d]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate by Williamson, Douglas S, Smith, Garrick P, Mikkelsen, Gitte K, Jensen, Thomas, Acheson-Dossang, Pamela, Badolo, Lassina, Bedford, Simon T, Chell, Victoria, Chen, I-Jen, Dokurno, Pawel, Hentzer, Morten, Newland, Samantha, Ray, Stuart C, Shaw, Terry, Surgenor, Allan E, Terry, Lindsey, Wang, Yikang, Christensen, Kenneth V

“…Inhibitors of leucine-rich repeat kinase 2 (LRRK2) and mutants, such as G2019S, have potential utility in Parkinson’s disease treatment. Fragment hit-derived…”
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A Mouse Model that Recapitulates Cardinal Features of the 15q13.3 Microdeletion Syndrome Including Schizophrenia- and Epilepsy-Related Alterations by Fejgin, Kim, Nielsen, Jacob, Birknow, Michelle R, Bastlund, Jesper F, Nielsen, Vibeke, Lauridsen, Jes B, Stefansson, Hreinn, Steinberg, Stacy, Sorensen, Helge B.D, Mortensen, Troels E, Larsen, Peter H, Klewe, Ib V, Rasmussen, Søren V, Stefansson, Kari, Werge, Thomas M, Kallunki, Pekka, Christensen, Kenneth V, Didriksen, Michael

“…Background Genome-wide scans have uncovered rare copy number variants conferring high risk of psychiatric disorders. The 15q13.3 microdeletion is associated…”
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Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1) by Williamson, Douglas S, Smith, Garrick P, Acheson-Dossang, Pamela, Bedford, Simon T, Chell, Victoria, Chen, I-Jen, Daechsel, Justus C. A, Daniels, Zoe, David, Laurent, Dokurno, Pawel, Hentzer, Morten, Herzig, Martin C, Hubbard, Roderick E, Moore, Jonathan D, Murray, James B, Newland, Samantha, Ray, Stuart C, Shaw, Terry, Surgenor, Allan E, Terry, Lindsey, Thirstrup, Kenneth, Wang, Yikang, Christensen, Kenneth V

“…Mutations in leucine-rich repeat kinase 2 (LRRK2), such as G2019S, are associated with an increased risk of developing Parkinson’s disease. Surrogates for the…”
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Abnormal visual gain control in a Parkinson's disease model by Afsari, Farinaz, Christensen, Kenneth V, Smith, Garrick Paul, Hentzer, Morten, Nippe, Olivia M, Elliott, Christopher J H, Wade, Alex R

“…Our understanding of Parkinson's disease (PD) has been revolutionized by the discovery of disease-causing genetic mutations. The most common of these is the…”
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Preexercise Energy Drink Consumption Does Not Improve Endurance Cycling Performance But Increases Lactate, Monocyte, and Interleukin-6 Response by Phillips, Melody D, Rola, Kelyn S, Christensen, Kenneth V, Ross, Jacob W, Mitchell, Joel B

“…ABSTRACTPhillips, MD, Rola, KS, Christensen, KV, Ross, JW, and Mitchell, JB. Preexercise energy drink consumption does not improve endurance cycling…”
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Recruitment of β-arrestin2 to the dopamine D2 receptor: Insights into anti-psychotic and anti-parkinsonian drug receptor signaling by Klewe, Ib V., Nielsen, Søren M., Tarpø, Louise, Urizar, Eneko, Dipace, Concetta, Javitch, Jonathan A., Gether, Ulrik, Egebjerg, Jan, Christensen, Kenneth V.

“…Drugs acting at dopamine D2-like receptors play a pivotal role in the treatment of both schizophrenia and Parkinson's disease. Recent studies have demonstrated…”
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Glucocorticoid Receptor and Myocyte Enhancer Factor 2 Cooperate to Regulate the Expression of c-JUN in a Neuronal Context by Speksnijder, Niels, Christensen, Kenneth V., Didriksen, Michael, De Kloet, E. Ronald, Datson, Nicole A.

“…The glucocorticoid receptor (GR) and myocyte enhancer factor 2 (MEF2) are transcription factors involved in neuronal plasticity. c-JUN, a target gene of GR and…”
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Over-expression, purification and characterization of an Asc-1 homologue from Gloeobacter violaceus by Wang, Xiaole, Hald, Helle, Ernst, Heidi A., Egebjerg, Jan, Christensen, Kenneth V., Gajhede, Michael, Kastrup, Jette S., Mirza, Osman

“…The human alanine–serine–cysteine transporter 1 (Asc-1) belongs to the slc7a family of solute carrier transporters. Asc-1 mediates the uptake of d-serine in an…”
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Support for a bipolar affective disorder susceptibility locus on chromosome 12q24.3 by Buttenschøn, Henriette Nørmølle, Buttenchøn, Henriette Nørmølle, Foldager, Leslie, Flint, Tracey J, Olsen, Inger Marie L, Deleuran, Thomas, Nyegaard, Mette, Hansen, Mette M, Kallunki, Pekka, Christensen, Kenneth V, Blackwood, Douglas H, Muir, Walter J, Straarup, Steen E, Als, Thomas D, Nordentoft, Merete, Børglum, Anders D, Mors, Ole

“…Linkage and association studies of bipolar affective disorder (BAD) point out chromosome 12q24 as a region of interest. To investigate this region further, we…”
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Correlation of the expression of kainate receptor subtypes to responses evoked in cultured cortical and spinal cord neurones by Dai, Wei-Min, Christensen, Kenneth V, Egebjerg, Jan, Ebert, Bjarke, Lambert, John D.C

“…Responses of cultured rat cortical and spinal cord neurones to kainate (KA) have been related to the expression of KA receptor subunits revealed by single-cell…”
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Larger intercellular variation in (Q/R) editing of GluR6 than GluR5 revealed by single cell RT-PCR by Christensen, Kenneth V, Dai, Wei-Min, Lambert, John D. C, Egebjerg, Jan

“…RNA editing of the pre-mRNA encoding the kainate receptor subtypes determines the Ca permeability and the rectifying properties of the receptors in which these…”
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The Effect of Short and Long Recovery Periods on the Contribution of Oxidative Processes to Energy Expenditure During Multiple Bouts of Supramaximal Exercise by Olson, Eric C, Christensen, Kenneth V, Jajtner, Adam, Copeland, Jen, Unthank, Matt, Mitchell, Joel B

“…The purpose of this study was to examine the effect of short and long active recovery durations on oxidative and anaerobic energy contributions during maximal…”
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Serum IL-6 Is Increased During Performance Cycling After Energy Drink Consumption: 2457 Board #65 June 4 9:00 AM - 10:30 AM by Woodson, Jonathan P., Phillips, Melody D., Ross, Jacob W., Rola, Kelyn S., Christensen, Kenneth V.

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