Search Results - "Christensen, Keegan A"

Auranofin inhibition of thioredoxin reductase sensitizes lung neuroendocrine tumor cells (NETs) and small cell lung cancer (SCLC) cells to sorafenib as well as inhibiting SCLC xenograft growth by Johnson, Spenser S, Liu, Dijie, Ewald, Jordan T, Robles-Planells, Claudia, Pulliam, Casey, Christensen, Keegan A, Bayanbold, Khaliunaa, Wels, Brian R, Solst, Shane R, O'Dorisio, M Sue, Menda, Yusuf, Spitz, Douglas R, Fath, Melissa A

“…Thioredoxin Reductase (TrxR) functions to recycle thioredoxin (Trx) during hydroperoxide metabolism mediated by peroxiredoxins and is currently being targeted…”
Get full text

Missense Mutations in Myc Box I Influence Nucleocytoplasmic Transport to Promote Leukemogenesis by Arthur, Nancy B J, Christensen, Keegan A, Mannino, Kathleen, Ruzinova, Marianna B, Kumar, Ashutosh, Gruszczynska, Agata, Day, Ryan B, Erdmann-Gilmore, Petra, Mi, Yiling, Sprung, Robert, York, Conner R, Townsend, Robert R, Spencer, David H, Sykes, Stephen M, Ferraro, Francesca

“…Somatic missense mutations in the phosphodegron domain of the MYC gene (MYC Box I or MBI) are detected in the dominant clones of a subset of patients with…”
Get full text

Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes by Ferraro, Francesca, Miller, Christopher A., Christensen, Keegan A., Helton, Nichole M., O’Laughlin, Margaret, Fronick, Catrina C., Fulton, Robert S., Kohlschmidt, Jessica, Eisfeld, Ann-Kathrin, Bloomfield, Clara D., Ramakrishnan, Sai Mukund, Day, Ryan B., Wartman, Lukas D., Uy, Geoffrey L., Welch, John S., Christopher, Matthew J., Heath, Sharon E., Baty, Jack D., Schuelke, Matthew J., Payton, Jacqueline E., Spencer, David H., Rettig, Michael P., Link, Daniel C., Walter, Matthew J., Westervelt, Peter, DiPersio, John F., Ley, Timothy J.

“…Acute myeloid leukemia (AML) patients rarely have long first remissions (LFRs; >5 y) after standard-of-care chemotherapy, unless classified as favorable risk…”
Get full text

MYC Influences mRNA Processing and Nuclear Export to Initiate Acute Myeloid Leukemia by Arthur, Nancy, Christensen, Keegan A, Mannino, Kathleen, Sykes, Stephen M., Kumar, Ashutosh, Helton, Nichole M, Gruszczynska, Agata, Ley, Timothy J, Ferraro, Francesca

Get full text

Adverse Outcomes in Acute Myeloid Leukemia Are Associated with Tumor Cell-Mediated Immunosuppression by Ferraro, Francesca, Miller, Christopher A, Christensen, Keegan A, Helton, Nichole M, O'Laughlin, Michelle, Fulton, Robert, Kohlschmidt, Jessica, Eisfeld, Ann-Kathrin, Clara, Bloomfield, Ramakrishnan, Sai Mukund, Wartman, Lukas D, Welch, John, Christopher, Matthew, Heath, Sharon E, Westervelt, Peter, Baty, Jack D, Payton, Jacqueline E., Retting, Michael, Link, Daniel C., Walter, Matthew J., DiPersio, John F., Day, Ryan, Uy, Geoffrey L., Schuelke, Matthew, Spencer, David H, Ley, Timothy J

“…Background: A normal karyotype is the most common cytogenetic finding in acute myeloid leukemia cells (“NK-AML”) and has highly variable and difficult to…”
Get full text

Abstract 5062: Small molecule superoxide dismutase mimetic avasopasem manganese for the mitigation of cisplatin induced ototoxicity by Christensen, Keegan A., Tarabichi, Osama, Sho, Sei, Hernández, Hidaly, Hunger, Bryce, Fath, Melissa A., Keene, Jeffery, Beardsley, Robert, Hansen, Marlan, Spitz, Douglas R.

“…Abstract Introduction: Avasopasem manganese (GC4419) is a selective superoxide dismutase mimetic which has recently completed a Phase 3 clinical trial…”
Get full text

Abstract 5034: Targeting CXCR4 and thioredoxin reductase in high grade neuroendocrine tumors and neuroendocrine carcinomas by Fath, Melissa A., Liu, Dijie, Robles-Planells, Claudia, Ewald, Jordan T., Christensen, Keegan A., Johnson, Spenser S., Graves, Stephen A., Spitz, Douglas R., Menda, Yusuf, Sue O’Dorisio, M.

“…Abstract Introduction/Background: Atypical lung carcinoids and lung neuroendocrine carcinomas (NECs) are currently incurable. Most of these cancers express the…”
Get full text