Search Results - "Christensen, E M"

Voice analysis as an objective state marker in bipolar disorder by Faurholt-Jepsen, M, Busk, J, Frost, M, Vinberg, M, Christensen, E M, Winther, O, Bardram, J E, Kessing, L V

“…Changes in speech have been suggested as sensitive and valid measures of depression and mania in bipolar disorder. The present study aimed at investigating (1)…”
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Daily electronic self-monitoring in bipolar disorder using smartphones - the MONARCA I trial: a randomized, placebo-controlled, single-blind, parallel group trial by Faurholt-Jepsen, M, Frost, M, Ritz, C, Christensen, E M, Jacoby, A S, Mikkelsen, R L, Knorr, U, Bardram, J E, Vinberg, M, Kessing, L V

“…The number of studies on electronic self-monitoring in affective disorder and other psychiatric disorders is increasing and indicates high patient acceptance…”
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From items to syndromes in the Hypomania Checklist (HCL-32): Psychometric validation and clinical validity analysis by Bech, P, Christensen, E.M, Vinberg, M, Bech-Andersen, G, Kessing, L.V

“…Abstract Background The Hypomania Checklist (HCL-32) was developed to identify subthreshold bipolarity in patients with major depression. An HCL-32 version…”
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Fine tuning of the catalytic activity of colicin E7 nuclease domain by systematic N‐terminal mutations by Németh, Eszter, Körtvélyesi, Tamás, Thulstrup, Peter W., Christensen, Hans E. M., Kožíšek, Milan, Nagata, Kyosuke, Czene, Anikó, Gyurcsik, Béla

“…The nuclease domain of colicin E7 (NColE7) promotes the nonspecific cleavage of nucleic acids at its C‐terminal HNH motif. Interestingly, the deletion of four…”
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The Biological Functions of Glutathione Revisited in Arabidopsis Transgenic Plants with Altered Glutathione Levels by Xiang, Chengbin, Bonnie L. Werner, E'Lise M. Christensen, Oliver, David J.

“…A functional analysis of the role of glutathione in protecting plants from environmental stress was undertaken by studying Arabidopsis that had been…”
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Long-range interfacial electron transfer of metalloproteins based on molecular wiring assemblies by Chi, Qijin, Zhang, Jingdong, Jensen, Palle S, Christensen, Hans E M, Ulstrup, Jens

“…We address some physical features associated with long-range interfacial electron transfer (ET) of metalloproteins in both electrochemical and electrochemical…”
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The role of the N-terminal loop in the function of the colicin E7 nuclease domain by Czene, Anikó, Németh, Eszter, Zóka, István G., Jakab-Simon, Noémi I., Körtvélyesi, Tamás, Nagata, Kyosuke, Christensen, Hans E. M., Gyurcsik, Béla

“…Colicin E7 (ColE7) is a metallonuclease toxin of Escherichia coli belonging to the HNH superfamily of nucleases. It contains highly conserved amino acids in…”
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Characterization of Conformational Exchange of a Histidine Side Chain: Protonation, Rotamerization, and Tautomerization of His61 in Plastocyanin from Anabaena variabilis by Hass, Mathias A. S, Hansen, D. Flemming, Christensen, Hans E. M, Led, Jens J, Kay, Lewis E

“…A model describing conformational exchange of His 61 in plastocyanin from Anabaena variabilis is presented. A detailed picture of the exchange dynamics has…”
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Psychometric validation and clinical validity of the Minor Melancholia Mood Checklist (MMCL-32) by Bech, P, Christensen, E.M, Vinberg, M, Bech-Andersen, G, Kessing, L.V

“…Abstract Background The Minor Melancholia Mood Checklist (MMCL-32) was developed to identify sub-threshold states of major depression. The MMCL-32 can be…”
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Isoform-Specific Substrate Inhibition Mechanism of Human Tryptophan Hydroxylase by Tidemand, Kasper D, Peters, Günther H, Harris, Pernille, Stensgaard, Eva, Christensen, Hans E. M

“…Tryptophan hydroxylase (TPH) catalyzes the initial and rate-limiting step in the biosynthesis of serotonin, which is associated with a variety of disorders…”
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Chemical Approach to Biological Safety: Molecular‐Level Control of an Integrated Zinc Finger Nuclease by Németh, Eszter, Asaka, Masamitsu N., Kato, Kohsuke, Fábián, Zita, Oostenbrink, Chris, Christensen, Hans E. M., Nagata, Kyosuke, Gyurcsik, Béla

“…Application of artificial nucleases (ANs) in genome editing is still hindered by their cytotoxicity related to off‐target cleavages. This problem can be…”
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The G-protein coupled estrogen receptor, GPER: The inside and inside-out story by Gaudet, H.M., Cheng, S.B., Christensen, E.M., Filardo, E.J.

“…GPER possesses structural and functional characteristics shared by members of the G-protein-coupled receptor (GPCR) superfamily, the largest class of plasma…”
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Isolation of clonogenic, long-term self renewing embryonic renal stem cells by Lusis, M, Li, J, Ineson, J, Christensen, M E, Rice, A, Little, M H

“…A tissue stem cell should exhibit long-term self-renewal, clonogenicity and a capacity to differentiate into the tissue of origin. Such a postnatal renal stem…”
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Direct coordination of pterin to FeII enables neurotransmitter biosynthesis in the pterin-dependent hydroxylases by Iyer, Shyam R., Tidemand, Kasper D., Babicz, Jeffrey T., Jacobs, Ariel B., Gee, Leland B., Haahr, Lærke T., Yoda, Yoshitaka, Kurokuzu, Masayuki, Kitao, Shinji, Saito, Makina, Seto, Makoto, Christensen, Hans E. M., Peters, Günther H. J., Solomon, Edward I.

“…The pterin-dependent nonheme iron enzymes hydroxylate aromatic amino acids to perform the biosynthesis of neurotransmitters to maintain proper brain function…”
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Evaluation of a concerted vs. sequential oxygen activation mechanism in α-ketoglutarate–dependent nonheme ferrous enzymes by Goudarzi, Serra, Iyer, Shyam R., Babicz, Jeffrey T., Yan, James J., Peters, Günther H. J., Christensen, Hans E. M., Hedman, Britt, Hodgson, Keith O., Solomon, Edward I.

“…Determining the requirements for efficient oxygen (O₂) activation is key to understanding how enzymes maintain efficacy and mitigate unproductive, often…”
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Accurate Computation of Reduction Potentials of 4Fe−4S Clusters Indicates a Carboxylate Shift in Pyrococcus furiosus Ferredoxin by Jensen, Kasper P, Ooi, Bee-Lean, Christensen, Hans E. M

“…This work describes the computation and accurate reproduction of subtle shifts in reduction potentials for two mutants of the iron−sulfur protein Pyrococcus…”
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An efficient arabinoxylan-debranching α-l-arabinofuranosidase of family GH62 from Aspergillus nidulans contains a secondary carbohydrate binding site by Wilkens, Casper, Andersen, Susan, Petersen, Bent O., Li, An, Busse-Wicher, Marta, Birch, Johnny, Cockburn, Darrell, Nakai, Hiroyuki, Christensen, Hans E. M., Kragelund, Birthe B., Dupree, Paul, McCleary, Barry, Hindsgaul, Ole, Hachem, Maher Abou, Svensson, Birte

“…An α- l -arabinofuranosidase of GH62 from Aspergillus nidulans FGSC A4 ( An Abf62A-m2,3) has an unusually high activity towards wheat arabinoxylan (WAX)…”
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Substrate binding activates the designed triple mutant of the colicin E7 metallonuclease by Németh, Eszter, Körtvélyesi, Tamás, Kožíšek, Milan, Thulstrup, Peter W., Christensen, Hans E. M., Asaka, Masamitsu N., Nagata, Kyosuke, Gyurcsik, Béla

“…The nuclease domain of colicin E7 (NColE7) cleaves DNA nonspecifically. The active center is a Zn 2+ -containing HNH motif at the C-terminus. The N-terminal…”
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The 1.5 Å Resolution Crystal Structure of [Fe3S4]-Ferredoxin from the Hyperthermophilic Archaeon Pyrococcus furiosus by Nielsen, Michael S, Harris, Pernille, Ooi, Bee Lean, Christensen, Hans E. M

“…The structure of [Fe3S4]-ferredoxin from the hyperthermophilic archaeon Pyrococcus furiosus has been determined to 1.5 Å resolution from a crystal belonging to…”
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The association between mixed symptoms, irritability and functioning measured using smartphones in bipolar disorder by Faurholt‐Jepsen, M., Frost, M., Christensen, E. M., Bardram, J. E., Vinberg, M., Kessing, L. V.

“…Objective To (i) validate patient‐evaluated mixed symptoms and irritability measured using smartphones against clinical evaluations; (ii) investigate…”
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