Search Results - "Christen, L."

Audacity of Gene Therapy by Dimitrov, Marketa, Ebens, Christen L, Tolar, Jakub

“…Since the identification of DNA as the hereditary material, therapeutic advances have focused on gene therapy and allogeneic haematopoietic cell transplants…”
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Deconstructing progressive inflammatory fibrosis in recessive dystrophic epidermolysis bullosa by Ebens, Christen L

“…Recessive dystrophic epidermolysis bullosa (RDEB) is an inherited blistering skin disease, resulting from biallelic mutations in COL7A1, the gene encoding type…”
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Metagenome-Assembled Genomes of Novel Taxa from an Acid Mine Drainage Environment by Grettenberger, Christen L, Hamilton, Trinity L

“…Acid mine drainage (AMD) is a global problem in which iron sulfide minerals oxidize and generate acidic, metal-rich water. Bioremediation relies on…”
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Evaluating Shigella flexneri Pathogenesis in the Human Enteroid Model by Ranganathan, Sridevi, Doucet, Michele, Grassel, Christen L, Delaine-Elias, BreOnna, Zachos, Nicholas C, Barry, Eileen M

“…The enteric pathogen is one of the leading causes of moderate-to-severe diarrhea and death in young children in developing countries. Transformed cell lines…”
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Ankyloglossia and Tethered Oral Tissue: An Evidence-Based Review by Talmor, Guy, Caloway, Christen L

“…Tethered oral tissue may represent anatomic variation or true pathology with functional limitations. The most prevalent functional limitation is impaired…”
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Physiology, Not Nutrient Availability, May Have Limited Primary Productivity After the Emergence of Oxygenic Photosynthesis by Grettenberger, Christen L., Sumner, Dawn Y.

“…ABSTRACT The evolution of oxygenic photosynthesis in Cyanobacteria was a transformative event in Earth's history. However, the scientific community disagrees…”
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Novel Gloeobacterales spp. from Diverse Environments across the Globe by Grettenberger, Christen L

“…Photosynthetic and their descendants are the only known organisms capable of oxygenic photosynthesis. Their metabolism permanently changed the Earth's surface…”
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Machine learning can identify newly diagnosed patients with CLL at high risk of infection by Agius, Rudi, Brieghel, Christian, Andersen, Michael A., Pearson, Alexander T., Ledergerber, Bruno, Cozzi-Lepri, Alessandro, Louzoun, Yoram, Andersen, Christen L., Bergstedt, Jacob, von Stemann, Jakob H., Jørgensen, Mette, Tang, Man-Hung Eric, Fontes, Magnus, Bahlo, Jasmin, Herling, Carmen D., Hallek, Michael, Lundgren, Jens, MacPherson, Cameron Ross, Larsen, Jan, Niemann, Carsten U.

“…Infections have become the major cause of morbidity and mortality among patients with chronic lymphocytic leukemia (CLL) due to immune dysfunction and…”
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Update on hypoglossal nerve stimulation in children with down syndrome and obstructive sleep apnea by Caloway, Christen L., Diercks, Gillian R., Keamy, Donald, Guzman, Vanessa, Soose, Ryan, Raol, Nikhila, Shott, Sally R., Ishman, Stacey L., Hartnick, Christopher J.

“…Objectives/Hypothesis Hypoglossal nerve (HGN) stimulation is a novel therapy for obstructive sleep apnea (OSA) in adults. Its efficacy and safety in children…”
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Leading edge: emerging drug, cell, and gene therapies for junctional epidermolysis bullosa by Keith, Allison R, Twaroski, Kirk, Ebens, Christen L, Tolar, Jakub

“…Junctional epidermolysis bullosa (JEB) is a rare inherited genetic disorder with limited treatments beyond palliative care. A major hallmark of JEB is skin…”
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Metabolic diversity and co-occurrence of multiple Ferrovum species at an acid mine drainage site by Grettenberger, Christen L, Havig, Jeff R, Hamilton, Trinity L

“…Ferrovum spp. are abundant in acid mine drainage sites globally where they play an important role in biogeochemical cycling. All known taxa in this genus are…”
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A phylogenetically novel cyanobacterium most closely related to Gloeobacter by Grettenberger, Christen L., Sumner, Dawn Y., Wall, Kate, Brown, C. Titus, Eisen, Jonathan A., Mackey, Tyler J., Hawes, Ian, Jospin, Guillaume, Jungblut, Anne D.

“…Clues to the evolutionary steps producing innovations in oxygenic photosynthesis may be preserved in the genomes of organisms phylogenetically placed between…”
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Microglial priming through the lung—brain axis: the role of air pollution‐induced circulating factors by Mumaw, Christen L., Levesque, Shannon, McGraw, Constance, Robertson, Sarah, Lucas, Selita, Stafflinger, Jillian E, Campen, Matthew J., Hall, Pamela, Norenberg, Jeffrey P., Anderson, Tamara, Lund, Amie K., McDonald, Jacob D., Ottens, Andrew K., Block, Michelle L.

“…Air pollution is implicated in neurodegenerative disease risk and progression and in microglial activation, but the mechanisms are unknown. In this study,…”
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Bacterial community structure of microbial pinnacles in ice-covered Lake Vanda, Antarctica by Grettenberger, Christen L., Sumner, Dawn Y., Wall, Kate, Hawes, Ian, Mackey, Tyler, Jungblut, Anne D.

“…The McMurdo Dry Valleys are a cold and arid environment with low biomass relative to most ice-free environments. The ice-covered lakes in the valleys, however,…”
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The bidirectional lung brain-axis of amyloid-β pathology: ozone dysregulates the peri-plaque microenvironment by Greve, Hendrik J, Dunbar, August L, Lombo, Carla Garza, Ahmed, Chandrama, Thang, Morrent, Messenger, Evan J, Mumaw, Christen L, Johnson, James A, Kodavanti, Urmila P, Oblak, Adrian L, Block, Michelle L

“…Abstract The mechanisms underlying how urban air pollution affects Alzheimer’s disease (AD) are largely unknown. Ozone (O3) is a reactive gas component of air…”
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Immune-Mediated Cytopenias After Hematopoietic Cell Transplantation: Pathophysiology, Clinical Manifestations, Diagnosis, and Treatment Strategies by Michniacki, Thomas F., Ebens, Christen L., Choi, Sung Won

“…Purpose of Review Discuss the pathophysiology, clinical presentation, diagnosis, and treatment of immune-mediated cytopenias (IMC) after hematopoietic cell…”
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The role of CFA/I in adherence and toxin delivery by ETEC expressing multiple colonization factors in the human enteroid model by Smith, Emily M, Grassel, Christen L, Papadimas, Antonia, Foulke-Abel, Jennifer, Barry, Eileen M

“…Enterotoxigenic Escherichia coli (ETEC) is a primary causative agent of diarrhea in travelers and young children in low-to-middle-income countries (LMICs)…”
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ABCB5+ dermal mesenchymal stromal cells with favorable skin homing and local immunomodulation for recessive dystrophic epidermolysis bullosa treatment by Riedl, Julia, Pickett‐Leonard, Michael, Eide, Cindy, Kluth, Mark Andreas, Ganss, Christoph, Frank, Natasha Y., Frank, Markus H., Ebens, Christen L., Tolar, Jakub

“…Recessive dystrophic epidermolysis bullosa (RDEB) is a rare, incurable blistering skin disease caused by biallelic mutations in type VII collagen (C7)…”
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Interrogation of RDEB Epidermal Allografts after BMT Reveals Coexpression of Collagen VII and Keratin 15 with Proinflammatory Immune Cells and Fibroblasts by Riedl, Julia A., Riddle, Megan, Xia, Lily, Eide, Cindy, Boull, Christina, Ebens, Christen L., Tolar, Jakub

“…Recessive dystrophic epidermolysis bullosa (RDEB) is a devastating genodermatosis characterized by dysfunctional collagen VII protein resulting in epithelial…”
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Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function by Shouval, Dror S., Biswas, Amlan, Goettel, Jeremy A., McCann, Katelyn, Conaway, Evan, Redhu, Naresh S., Mascanfroni, Ivan D., Al Adham, Ziad, Lavoie, Sydney, Ibourk, Mouna, Nguyen, Deanna D., Samsom, Janneke N., Escher, Johanna C., Somech, Raz, Weiss, Batia, Beier, Rita, Conklin, Laurie S., Ebens, Christen L., Santos, Fernanda G.M.S., Ferreira, Alexandre R., Sherlock, Mary, Bhan, Atul K., Müller, Werner, Mora, J. Rodrigo, Quintana, Francisco J., Klein, Christoph, Muise, Aleixo M., Horwitz, Bruce H., Snapper, Scott B.

“…Intact interleukin-10 receptor (IL-10R) signaling on effector and T regulatory (Treg) cells are each independently required to maintain immune tolerance. Here…”
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