Search Results - "Christ, Daniel"

Clonal redemption of autoantibodies by somatic hypermutation away from self-reactivity during human immunization by Reed, Joanne H, Jackson, Jennifer, Christ, Daniel, Goodnow, Christopher C

“…Clonal anergy is an enigmatic self-tolerance mechanism because no apparent purpose is served by retaining functionally silenced B cells bearing autoantibodies…”
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Stability engineering of the human antibody repertoire by Rouet, Romain, Lowe, David, Christ, Daniel

“…Human monoclonal antibodies often display limited thermodynamic and colloidal stabilities. This behavior hinders their production, and places limitations on…”
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Efficient Intracellular Delivery of CRISPR-Cas Ribonucleoproteins through Receptor Mediated Endocytosis by Rouet, Romain, Christ, Daniel

“…We recently reported a new delivery system harnessing surface receptors for targeted uptake of CRISPR-Cas9 ribonucleoprotein into mammalian cells (Rouet et…”
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Clonal redemption and clonal anergy as mechanisms to balance B cell tolerance and immunity by Burnett, Deborah L., Reed, Joanne H., Christ, Daniel, Goodnow, Christopher C.

“…The adaptive immune system is tasked with producing antibodies that recognize a wide scope of potential pathogens, including those never before encountered,…”
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The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells by Gatto, Dominique, Wood, Katherine, Caminschi, Irina, Murphy-Durland, Danielle, Schofield, Peter, Christ, Daniel, Karupiah, Gunasegaran, Brink, Robert

“…Precise lymphoid tissue architecture is needed to generate adaptive immune responses. Brink and colleagues show that CD4 + DCs express the chemotactic receptor…”
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General strategy for the generation of human antibody variable domains with increased aggregation resistance by Dudgeon, Kip, Rouet, Romain, Kokmeijer, Iris, Schofield, Peter, Stolp, Jessica, Langley, David, Stock, Daniela, Christ, Daniel

“…The availability of stable human antibody reagents would be of considerable advantage for research, diagnostic, and therapeutic applications. Unfortunately,…”
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Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination by Burnett, Deborah L, Langley, David B, Schofield, Peter, Hermes, Jana R, Chan, Tyani D, Jackson, Jennifer, Bourne, Katherine, Reed, Joanne H, Patterson, Kate, Porebski, Benjamin T, Brink, Robert, Christ, Daniel, Goodnow, Christopher C

“…Antibodies have the specificity to differentiate foreign antigens that mimic self antigens, but it remains unclear how such specificity is acquired. In a mouse…”
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Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody by Singh, Mandeep, Jackson, Katherine J.L., Wang, Jing J., Schofield, Peter, Field, Matt A., Koppstein, David, Peters, Timothy J., Burnett, Deborah L., Rizzetto, Simone, Nevoltris, Damien, Masle-Farquhar, Etienne, Faulks, Megan L., Russell, Amanda, Gokal, Divya, Hanioka, Asami, Horikawa, Keisuke, Colella, Alexander D., Chataway, Timothy K., Blackburn, James, Mercer, Tim R., Langley, David B., Goodall, D. Margaret, Jefferis, Roy, Gangadharan Komala, Muralikrishna, Kelleher, Anthony D., Suan, Dan, Rischmueller, Maureen, Christ, Daniel, Brink, Robert, Luciani, Fabio, Gordon, Tom P., Goodnow, Christopher C., Reed, Joanne H.

“…Pathogenic autoantibodies arise in many autoimmune diseases, but it is not understood how the cells making them evade immune checkpoints. Here, single-cell…”
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Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity by Sabouri, Zahra, Schofield, Peter, Horikawa, Keisuke, Spierings, Emily, Kipling, David, Randall, Katrina L, Langley, David, Roome, Brendan, Vazquez-Lombardi, Rodrigo, Rouet, Romain, Hermes, Jana, Chan, Tyani D, Brink, Robert, Dunn-Walters, Deborah K, Christ, Daniel, Goodnow, Christopher C

“…The best-understood mechanisms for achieving antibody self/non-self discrimination discard self-reactive antibodies before they can be tested for binding…”
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Exploring Superacid‐Promoted Skeletal Reorganization of Aliphatic Nitrogen‐Containing Compounds by Artault, Maxime, Cantin, Thomas, Longuet, Mélissa, Vitse, Kassandra, Mbengo, Christ Daniel Matatu, Guégan, Frédéric, Michelet, Bastien, Martin‐Mingot, Agnès, Thibaudeau, Sébastien

“…Here we report a method to reorganize the core structure of aliphatic unsaturated nitrogen‐containing substrates exploiting polyprotonation in superacid…”
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Next-Generation Sequencing of Antibody Display Repertoires by Rouet, Romain, Jackson, Katherine J L, Langley, David B, Christ, Daniel

“…selection technology has transformed the development of therapeutic monoclonal antibodies. Using methods such as phage, ribosome, and yeast display, high…”
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Potent antitumour activity of interleukin-2-Fc fusion proteins requires Fc-mediated depletion of regulatory T-cells by Vazquez-Lombardi, Rodrigo, Loetsch, Claudia, Zinkl, Daniela, Jackson, Jennifer, Schofield, Peter, Deenick, Elissa K., King, Cecile, Phan, Tri Giang, Webster, Kylie E., Sprent, Jonathan, Christ, Daniel

“…Interleukin-2 (IL-2) is an established therapeutic agent used for cancer immunotherapy. Since treatment efficacy is mediated by CD8 + and NK cell activity at…”
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Selection of human antibody fragments by phage display by Christ, Daniel, Lee, Carol M Y, Iorno, Niccolo, Sierro, Frederic

“…Here, we describe a protocol for the selection of human antibody fragments using repertoires displayed on filamentous bacteriophage. Antigen-specific clones…”
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SARS-CoV-2 Omicron BA.5: Evolving tropism and evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concern by Aggarwal, Anupriya, Akerman, Anouschka, Milogiannakis, Vanessa, Silva, Mariana Ruiz, Walker, Gregory, Stella, Alberto Ospina, Kindinger, Andrea, Angelovich, Thomas, Waring, Emily, Amatayakul-Chantler, Supavadee, Roth, Nathan, Manni, Sandro, Hauser, Thomas, Barnes, Thomas, Condylios, Anna, Yeang, Malinna, Wong, Maureen, Jean, Tyra, Foster, Charles S.P., Christ, Daniel, Hoppe, Alexandra Carey, Munier, Mee Ling, Darley, David, Churchill, Melissa, Stark, Damien J., Matthews, Gail, Rawlinson, William D., Kelleher, Anthony D., Turville, Stuart G.

“…Genetically distinct viral variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been recorded since January 2020. The introduction of…”
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Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients by Rouet, Romain, Henry, Jake Y., Johansen, Matt D., Sobti, Meghna, Balachandran, Harikrishnan, Langley, David B., Walker, Gregory J., Lenthall, Helen, Jackson, Jennifer, Ubiparipovic, Stephanie, Mazigi, Ohan, Schofield, Peter, Burnett, Deborah L., Brown, Simon H. J., Martinello, Marianne, Hudson, Bernard, Gilroy, Nicole, Post, Jeffrey J., Kelleher, Anthony, Jäck, Hans-Martin, Goodnow, Christopher C., Turville, Stuart G., Rawlinson, William D., Bull, Rowena A., Stewart, Alastair G., Hansbro, Philip M., Christ, Daniel

“…Emerging variants of concern (VOCs) are threatening to limit the effectiveness of SARS-CoV-2 monoclonal antibodies and vaccines currently used in clinical…”
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Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses by Balachandran, Harikrishnan, Phetsouphanh, Chansavath, Agapiou, David, Adhikari, Anurag, Rodrigo, Chaturaka, Hammoud, Mohamed, Shrestha, Lok Bahadur, Keoshkerian, Elizabeth, Gupta, Money, Turville, Stuart, Christ, Daniel, King, Cecile, Sasson, Sarah C., Bartlett, Adam, Grubor-Bauk, Branka, Rawlinson, William, Aggarwal, Anupriya, Stella, Alberto Ospina, Klemm, Vera, Mina, Michael M., Post, Jeffrey J., Hudson, Bernard, Gilroy, Nicky, Konecny, Pam, Ahlenstiel, Golo, Dwyer, Dominic E., Sorrell, Tania C., Kelleher, Anthony, Tedla, Nicodemus, Lloyd, Andrew R., Martinello, Marianne, Bull, Rowena A.

“…Understanding the long-term maintenance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity is critical for predicting protection against…”
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Cancer-associated noncoding mutations affect RNA G-quadruplex-mediated regulation of gene expression by Zeraati, Mahdi, Moye, Aaron L., Wong, Jason W. H., Perera, Dilmi, Cowley, Mark J., Christ, Daniel U., Bryan, Tracy M., Dinger, Marcel E.

“…Cancer is a multifactorial disease driven by a combination of genetic and environmental factors. Many cancer driver mutations have been characterised in…”
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Systematic functional identification of cancer multi-drug resistance genes by Lau, Man-Tat, Ghazanfar, Shila, Parkin, Ashleigh, Chou, Angela, Rouaen, Jourdin R, Littleboy, Jamie B, Nessem, Danielle, Khuong, Thang M, Nevoltris, Damien, Schofield, Peter, Langley, David, Christ, Daniel, Yang, Jean, Pajic, Marina, Neely, G Gregory

“…Drug resistance is a major obstacle in cancer therapy. To elucidate the genetic factors that regulate sensitivity to anti-cancer drugs, we performed…”
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Comparison of failure modes and effects analyses and time for brachytherapy ring and tandem applicator digitization between manual and solid applicator source placement methods by Holtman, Adia L., DiCostanzo, Dominic J., Zimmerman, Charles A., Graeper, Gavin, Woollard, Jeffrey, Christ, Daniel F., Cetnar, Ashley J.

“…Purpose Ring and tandem (R&T) applicator digitization is currently performed at our institution by manually defining the extent of the applicators…”
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Surface-associated antigen induces permeabilization of primary mouse B-cells and lysosome exocytosis facilitating antigen uptake and presentation to T-cells by Maeda, Fernando Y, van Haaren, Jurriaan Jh, Langley, David B, Christ, Daniel, Andrews, Norma W, Song, Wenxia

“…B-cell receptor (BCR)-mediated antigen internalization and presentation are essential for humoral memory immune responses. Antigen encountered by B-cells is…”
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