Search Results - "Christ, Annabel"

Endocytic receptor LRP2/megalin—of holoprosencephaly and renal Fanconi syndrome by Willnow, Thomas E., Christ, Annabel

“…Megalin (or LRP2) is an endocytic receptor that plays a central role in embryonic development and adult tissue homeostasis. Loss of this receptor in congenital…”
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Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects by Franken, Gijs A. C., Seker, Murat, Bos, Caro, Siemons, Laura A. H., van der Eerden, Bram C. J., Christ, Annabel, Hoenderop, Joost G. J., Bindels, René J. M., Müller, Dominik, Breiderhoff, Tilman, de Baaij, Jeroen H. F.

“…Patients with mutations in Cyclin M2 (CNNM2) suffer from hypomagnesaemia, seizures, and intellectual disability. Although the molecular function of CNNM2 is…”
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LRP2 Is an Auxiliary SHH Receptor Required to Condition the Forebrain Ventral Midline for Inductive Signals by Christ, Annabel, Christa, Anna, Kur, Esther, Lioubinski, Oleg, Bachmann, Sebastian, Willnow, Thomas E., Hammes, Annette

“…Sonic hedgehog (SHH) is a regulator of forebrain development that acts through its receptor, patched 1. However, little is known about cellular mechanisms at…”
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Cdon mutation and fetal alcohol converge on Nodal signaling in a mouse model of holoprosencephaly by Hong, Mingi, Christ, Annabel, Christa, Anna, Willnow, Thomas E, Krauss, Robert S

“…Holoprosencephaly (HPE), a defect in midline patterning of the forebrain and midface, arises ~1 in 250 conceptions. It is associated with predisposing…”
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LRP2 Acts as SHH Clearance Receptor to Protect the Retinal Margin from Mitogenic Stimuli by Christ, Annabel, Christa, Anna, Klippert, Julia, Eule, J. Corinna, Bachmann, Sebastian, Wallace, Valerie A., Hammes, Annette, Willnow, Thomas E.

“…During forebrain development, LRP2 promotes morphogen signaling as an auxiliary SHH receptor. However, in the developing retina, LRP2 assumes the opposing…”
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Endocytic receptor-mediated control of morphogen signaling by Willnow, Thomas E, Christ, Annabel, Hammes, Annette

“…Receptor-mediated endocytosis provides a mechanism by which cells take up signaling molecules from the extracellular space. Recent studies have shown that one…”
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LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche by Gajera, Chandresh R, Emich, Helena, Lioubinski, Oleg, Christ, Annabel, Beckervordersandforth-Bonk, Ruth, Yoshikawa, Kazuaki, Bachmann, Sebastian, Christensen, Erik Ilsø, Götz, Magdalena, Kempermann, Gerd, Peterson, Andrew S, Willnow, Thomas E, Hammes, Annette

“…The microenvironment of growth factors in the subependymal zone (SEZ) of the adult brain provides the instructive milieu for neurogenesis to proceed in this…”
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Establishment of a Neuroepithelial Barrier by Claudin5a Is Essential for Zebrafish Brain Ventricular Lumen Expansion by Zhang, Jingjing, Piontek, Jörg, Wolburg, Hartwig, Piehl, Christian, Liss, Martin, Otten, Cécile, Christ, Annabel, Willnow, Thomas E., Blasig, Ingolf E., Abdelilah-Seyfried, Salim, Dawid, Igor B.

“…Lumen expansion driven by hydrostatic pressure occurs during many morphogenetic processes. Although it is well established that members of the Claudin family…”
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Foxg1-Cre Mediated Lrp2 Inactivation in the Developing Mouse Neural Retina, Ciliary and Retinal Pigment Epithelia Models Congenital High Myopia by Cases, Olivier, Joseph, Antoine, Obry, Antoine, Santin, Mathieu D, Ben-Yacoub, Sirine, Pâques, Michel, Amsellem-Levera, Sabine, Bribian, Ana, Simonutti, Manuel, Augustin, Sébastien, Debeir, Thomas, Sahel, José Alain, Christ, Annabel, de Castro, Fernando, Lehéricy, Stéphane, Cosette, Pascal, Kozyraki, Renata

“…Myopia is a common ocular disorder generally due to increased axial length of the eye-globe. Its extreme form high myopia (HM) is a multifactorial disease…”
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Sortilin regulates sorting and secretion of Sonic hedgehog by Campbell, Charles, Beug, Shawn, Nickerson, Philip E B, Peng, Jimmy, Mazerolle, Chantal, Bassett, Erin A, Ringuette, Randy, Jama, Fadumo A, Morales, Carlos, Christ, Annabel, Wallace, Valerie A

“…Sonic Hedgehog (Shh) is a secreted morphogen that is an essential regulator of patterning and growth. The Shh full-length protein undergoes autocleavage in the…”
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LRP2 controls sonic hedgehog-dependent differentiation of cardiac progenitor cells during outflow tract formation by Christ, Annabel, Marczenke, Maike, Willnow, Thomas E

“…Abstract Conotruncal malformations are a major cause of congenital heart defects in newborn infants. Recently, genetic screens in humans and in mouse models…”
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LRP2, an auxiliary receptor that controls sonic hedgehog signaling in development and disease by Christ, Annabel, Herzog, Katja, Willnow, Thomas E.

“…To fulfill their multiple roles in organ development and adult tissue homeostasis, hedgehog (HH) morphogens act through their receptor Patched (PTCH) on target…”
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Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames by Sandmann, Clara-L., Schulz, Jana F., Ruiz-Orera, Jorge, Kirchner, Marieluise, Ziehm, Matthias, Adami, Eleonora, Marczenke, Maike, Christ, Annabel, Liebe, Nina, Greiner, Johannes, Schoenenberger, Aaron, Muecke, Michael B., Liang, Ning, Moritz, Robert L., Sun, Zhi, Deutsch, Eric W., Gotthardt, Michael, Mudge, Jonathan M., Prensner, John R., Willnow, Thomas E., Mertins, Philipp, van Heesch, Sebastiaan, Hubner, Norbert

“…All species continuously evolve short open reading frames (sORFs) that can be templated for protein synthesis and may provide raw materials for evolutionary…”
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LRP2 contributes to planar cell polarity-dependent coordination of motile cilia function by Bunatyan, Lena, Margineanu, Anca, Boutin, Camille, Montcouquiol, Mireille, Bachmann, Sebastian, Ilsø Christensen, Erik, Willnow, Thomas E., Christ, Annabel

“…Motile cilia are protruding organelles on specialized epithelia that beat in a synchronous fashion to propel extracellular fluids. Coordination and orientation…”
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GAS1 is required for NOTCH-dependent facilitation of SHH signaling in the ventral forebrain neuroepithelium by Marczenke, Maike, Sunaga-Franze, Daniele Yumi, Popp, Oliver, Althaus, Irene W, Sauer, Sascha, Mertins, Philipp, Christ, Annabel, Allen, Benjamin L, Willnow, Thomas E

“…Growth arrest-specific 1 (GAS1) acts as a co-receptor to patched 1, promoting sonic hedgehog (SHH) signaling in the developing nervous system. GAS1 mutations…”
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Impaired vitreous composition and retinal pigment epithelium function in the FoxG1::LRP2 myopic mice by Cases, Olivier, Obry, Antoine, Ben-Yacoub, Sirine, Augustin, Sébastien, Joseph, Antoine, Toutirais, Géraldine, Simonutti, Manuel, Christ, Annabel, Cosette, Pascal, Kozyraki, Renata

“…High myopia (HM) is one of the main causes of visual impairment and blindness all over the world and an unsolved medical problem. Persons with HM are…”
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Sortilin regulates sorting and secretion of Sonic hedgehog by Campbell, Charles, Beug, Shawn, Nickerson, Philip E. B., Peng, Jimmy, Mazerolle, Chantal, Bassett, Erin A., Ringuette, Randy, Jama, Fadumo A., Morales, Carlos, Christ, Annabel, Wallace, Valerie A.

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LRP2/megalin regulates forebrain patterning by modulating morphogen pathways by Christ, Annabel, Lioubinski, Oleg, Willnow, Thomas, Hammes, Annette

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The soluble intracellular domain of megalin does not affect renal proximal tubular function in vivo by Christ, Annabel, Terryn, Sara, Schmidt, Vanessa, Christensen, Erik I., Huska, Matthew R., Andrade-Navarro, Miguel A., Hübner, Norbert, Devuyst, Olivier, Hammes, Annette, Willnow, Thomas E.

“…Megalin-mediated endocytic uptake constitutes the main pathway for clearance of plasma proteins from the glomerular filtrate in proximal tubules. Little is…”
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LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche by Gajera, Chandresh R., Emich, Helena, Lioubinski, Oleg, Christ, Annabel, Beckervordersandforth-Bonk, Ruth, Yoshikawa, Kazuaki, Bachmann, Sebastian, Christensen, Erik Ilsø, Götz, Magdalena, Kempermann, Gerd, Peterson, Andrew S., Willnow, Thomas E., Hammes, Annette

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