Search Results - "Chrebet, G"

Specific Substitutions in the Echinocandin Target Fks1p Account for Reduced Susceptibility of Rare Laboratory and Clinical Candida sp. Isolates by PARK, S, KELLY, R, FLATTERY, A, GILL, C, CHREBET, G, PARENT, S. A, KURTZ, M, TEPPLER, H, DOUGLAS, C. M, PERLIN, D. S, KAHN, J. Nielsen, ROBLES, J, HSU, M.-J, REGISTER, E, LI, W, VYAS, V, FAN, H, ABRUZZO, G

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Cell-based assays to detect inhibitors of fungal mRNA capping enzymes and characterization of sinefungin as a cap methyltransferase inhibitor by Chrebet, Gary L, Wisniewski, Douglas, Perkins, Ann L, Deng, Qiaolin, Kurtz, Myra B, Marcy, Alice, Parent, Stephen A

“…The m7GpppN cap at the 5' end of eukaryotic mRNAs is important for transcript stability and translation. Three enzymatic activities that generate the mRNA cap…”
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Antifungal properties of the immunosuppressant FK-506: identification of an FK-506-responsive yeast gene distinct from FKB1 by Brizuela, L, Chrebet, G, Bostian, K A, Parent, S A

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Yeast FKBP-13 is a Membrane-Associated FK506-Binding Protein Encoded by the Nonessential Gene FKB2 by Nielsen, Jennifer B., Foor, Forrest, Siekierka, John J., Hsu, Ming-Jo, Ramadan, Naasa, Morin, Nancy, Shafiee, Ali, Dahl, Arlene M., Brizuela, Leonardo, Chrebet, Gary, Bostian, Keith A., Parent, Stephen A.

“…The immunosuppressants FK506 and rapamycin prevent T-cell activation and also inhibit the growth of certain strains of the yeast Saccharomyces cerevisiae. It…”
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A Rational Utilization of High-Throughput Screening Affords Selective, Orally Bioavailable 1-Benzyl-3-carboxyazetidine Sphingosine-1-phosphate-1 Receptor Agonists by Hale, Jeffrey J, Lynch, Christopher L, Neway, William, Mills, Sander G, Hajdu, Richard, Keohane, Carol Ann, Rosenbach, Mark J, Milligan, James A, Shei, Gan-Ju, Parent, Stephen A, Chrebet, Gary, Bergstrom, James, Card, Deborah, Ferrer, Marc, Hodder, Peter, Strulovici, Berta, Rosen, Hugh, Mandala, Suzanne

“…Moderately potent, selective S1P1 receptor agonists identified from high-throughput screening have been adapted into lipophilic tails for a class of orally…”
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Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720 by Hale, Jeffrey J., Neway, William, Mills, Sander G., Hajdu, Richard, Ann Keohane, Carol, Rosenbach, Mark, Milligan, James, Shei, Gan-Ju, Chrebet, Gary, Bergstrom, James, Card, Deborah, Koo, Gloria C., Koprak, Sam L., Jackson, Jesse J., Rosen, Hugh, Mandala, Suzanne

“…The in vitro and in vivo properties of 19 support a connection between S1P receptor agonism and immunosuppressive efficacy. Alteration in lymphocyte…”
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2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors by Yan, Lin, Budhu, Richard, Huo, Pei, Lynch, Christopher L., Hale, Jeffrey J., Mills, Sander G., Hajdu, Richard, Keohane, Carol A., Rosenbach, Mark J., Milligan, James A., Shei, Gan-Ju, Chrebet, Gary, Bergstrom, James, Card, Deborah, Mandala, Suzanne M.

“…A series of 2-aryl(pyrrolidine-4-yl)acetic acids (e.g., 22g) were synthesized and evaluated as S1P receptor agonists and were found to lower peripheral…”
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A hyper-recombination mutation in S. cerevisiae identifies a novel eukaryotic topoisomerase by Wallis, J W, Chrebet, G, Brodsky, G, Rolfe, M, Rothstein, R

“…A hyper-recombination mutation was isolated that causes an increase in recombination between short repeated delta sequences surrounding the SUP4-omicron gene…”
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Design and synthesis of conformationally constrained 3-( N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors by Yan, Lin, Hale, Jeffrey J., Lynch, Christopher L., Budhu, Richard, Gentry, Amy, Mills, Sander G., Hajdu, Richard, Keohane, Carol Ann, Rosenbach, Mark J., Milligan, James A., Shei, Gan-Ju, Chrebet, Gary, Bergstrom, James, Card, Deborah, Rosen, Hugh, Mandala, Suzanne M.

“…A series of conformationally constrained analogs of 3 were synthesized and evaluated as S1P receptor agonists. Several novel scaffolds were identified as…”
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Calcineurin-dependent growth of an FK506- and CsA-hypersensitive mutant of Saccharomyces cerevisiae by Parent, S.A, Nielsen, J.B, Morin, N, Chrebet, G, Ramadan, N, Dahl, A.M, Hsu, M.J, Bostian, K.A, Foor, F

“…The immunosuppressants FK506 and cyclosporin A (CsA) bound to their receptors, FKBP12 or cyclophilin, inhibit the Ca2+/calmodulin-dependent protein…”
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The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists by Hale, Jeffrey J., Doherty, George, Toth, Leslie, Li, Zhen, Mills, Sander G., Hajdu, Richard, Ann Keohane, Carol, Rosenbach, Mark, Milligan, James, Shei, Gan-Ju, Chrebet, Gary, Bergstrom, James, Card, Deborah, Rosen, Hugh, Mandala, Suzanne

“…3-(N-Alkylamino)propylphosphinic acids exemplified by 29 are potent agonists of four of the five known sphingosine-1-phosphate (S1P) receptor subtypes…”
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Discovery of Potent 3,5-Diphenyl-1,2,4-oxadiazole Sphingosine-1-phosphate-1 (S1P sub(1)) Receptor Agonists with Exceptional Selectivity against S1P sub(2) and S1P sub(3) by Li, Z, Chen, W, Hale, J J, Lynch, CL, Mills, S G, Hajdu, R, Keohane, CA, Rosenbach, MJ, Milligan, JA, Shei, G-J, Chrebet, G, Parent, SA, Bergstrom, J, Card, D

“…A class of 3,5-diphenyl-1,2,4-oxadiazole based compounds have been identified as potent sphingosine-1-phosphate-1 (S1P sub(1)) receptor agonists with minimal…”
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Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from α-factor arrest in yeast by Poor, Forrest, Parent, Stephen A, Morin, Nancy, Dahl, Arlene M, Ramadan, Naasa, Chrebet, Gary, Bostian, Keith A, Nielsen, Jennifer B

“…The structurally unrelated immunosuppressants FK506 and cyclosporin A (CsA) act similarly, inhibiting a Ca(2+)-dependent signal required for interleukin-2…”
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Molecular characterization of the murine SIGNR1 gene encoding a C-type lectin homologous to human DC-SIGN and DC-SIGNR by Parent, Stephen A, Zhang, Theresa, Chrebet, Gary, Clemas, Joseph A, Figueroa, David J, Ky, Betty, Blevins, Richard A, Austin, Christopher P, Rosen, Hugh

“…The C-type lectin human dendritic cell (DC)-specific intercellular adhesion molecule (ICAM)-3-grabbing non-integrin (DC-SIGN) plays important roles in pattern…”
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Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent FTY720 by Hale, Jeffrey J., Yan, Lin, Neway, William E., Hajdu, Richard, Bergstrom, James D., Milligan, James A., Shei, Gan-Ju, Chrebet, Gary L., Thornton, Rosemary A., Card, Deborah, Rosenbach, Mark, HughRosen, Mandala, Suzanne

“…[Display omitted] The novel immunosuppressive agent FTY720 (1) is phosphorylated in vivo in a variety of species yielding an active metabolite that is an…”
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Antifungal properties of the immunosuppressant FK-506 : identification of an FK-506-responsive yeast gene distinct from FKBl by BRIZUELA, L, CHREBET, G, BOSTIAN, K. A, PARENT, S. A

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Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from alpha-factor arrest in yeast by Foor, F, Parent, S.A, Morin, N, Dahl, A.M, Ramadan, N, Chrebet, G, Bostian, K.A, Nielsen, J.B

“…The structurally unrelated immunosuppressants FK506 and cyclosporin A (CsA) act similarly, inhibiting a Ca2+-dependent signal required for interleukin-2…”
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