Search Results - "Chowen, J A"

Metabolomics allows the discrimination of the pathophysiological relevance of hyperinsulinism in obese prepubertal children by Martos-Moreno, G Á, Mastrangelo, A, Barrios, V, García, A, Chowen, J A, Rupérez, F J, Barbas, C, Argente, J

“…Background/Objectives: Insulin resistance (IR) is the cornerstone of the obesity-associated metabolic derangements observed in obese children. Targeted…”
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Activation of Microglia in Specific Hypothalamic Nuclei and the Cerebellum of Adult Rats Exposed to Neonatal Overnutrition by Tapia-González, S., García-Segura, Lhav M., Tena-Sempere, M., Frago, L. M., Castellano, J. M., Fuente-Martín, E., García-Cáceres, C., Argente, J., Chowen, J. A.

“…Much attention has been drawn to the possible involvement of hypothalamic inflammation in the pathogenesis of metabolic disorders, especially in response to a…”
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Functional Interaction between Opioid and Cannabinoid Receptors in Drug Self-Administration by Navarro, M, Carrera, M. R. A, Fratta, W, Valverde, O, Cossu, G, Fattore, L, Chowen, J. A, Gomez, R, del Arco, I, Villanua, M. A, Maldonado, R, Koob, G. F, de Fonseca, F. Rodriguez

“…The present study was designed to explore the relationship between the cannabinoid and opioid receptors in animal models of opioid-induced reinforcement. The…”
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Metabolic signals in human puberty: Effects of over and undernutrition by Martos-Moreno, G.Á., Chowen, J.A., Argente, J.

“…Puberty in mammals is associated with important physical and psychological changes due to the increase in sex steroids and growth hormone (GH). Indeed, an…”
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Neonatal Treatment with a Pegylated Leptin Antagonist has a Sexually Dimorphic Effect on Hypothalamic Trophic Factors and Neuropeptide Levels by Mela, V., Díaz, F., Gertler, A., Solomon, G., Argente, J., Viveros, M.-P., Chowen, J. A.

“…It is clear that the prenatal and early neonatal environments are important for determining the metabolic equilibrium in the adult animal, with…”
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Acute up-regulation of the rat brain somatostatin receptor-effector system by leptin is related to activation of insulin signaling and may counteract central leptin actions by Perianes-Cachero, A, Burgos-Ramos, E, Puebla-Jiménez, L, Canelles, S, Frago, L.M, Hervás-Aguilar, A, de Frutos, S, Toledo-Lobo, M.V, Mela, V, Viveros, M.P, Argente, J, Chowen, J.A, Arilla-Ferreiro, E, Barrios, V

“…Highlights • The leptin-related increase of the somatostatinergic tone is due to a rise in sst2. • The rise in receptor subtype 2 is coincident with c-Jun and…”
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Death of Hypothalamic Astrocytes in Poorly Controlled Diabetic Rats is Associated with Nuclear Translocation of Apoptosis Inducing Factor by García-Cáceres, C., Lechuga-Sancho, A., Argente, J., Frago, L. M., Chowen, J. A.

“…Astrocytes in the hypothalamus of poorly controlled diabetic rats are reduced in number, due to increased apoptosis and decreased proliferation, and undergo…”
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Multiple endocrine abnormalities of the growth hormone and insulin-like growth factor axis in patients with anorexia nervosa : Effect of short- and long-term weight recuperation by ARGENTE, J, CABALLO, N, BARRIOS, V, MUNOZ, M. T, POZO, J, CHOWEN, J. A, MORANDE, G, HERNANDEZ, M

“…We have studied the GH-insulin-like growth factor (IGF) axis in patients with anorexia nervosa at the time of diagnosis and at two points during weight…”
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Multiple endocrine abnormalities of the growth hormone and insulin-like growth factor axis in prepubertal children with exogenous obesity : Effect of short- and long-term weight reduction by ARGENTE, J, CABALLO, N, BARRIOS, V, POZO, J, MUNOZ, M. T, CHOWEN, J. A, HERNANDEZ, M

“…We have studied the GH-insulin-like growth factor (IGF) axis in prepubertal children with exogenous obesity at the time of clinical diagnosis and at two time…”
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Peripheral versus central effects of glucagon-like peptide-1 receptor agonists on satiety and body weight loss in Zucker obese rats by Rodriquez de Fonseca, Fernando, Navarro, Miguel, Alvarez, Elvira, Roncero, Isabel, Chowen, Julie A., Maestre, Olivia, Gómez, Raquel, Muñoz, Raúl M., Eng, John, Blázquez, Enrique

“…The present study explores the potential utility of peripheral versus central administration of glucagon-like peptide-1 (GLP-1) receptor agonists in the…”
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Effect of a high-fat diet and leptin on STAT3 phosphorylation in hippocampal astrocytes by Naranjo, V., Merino, Beatriz, Del Olmo, N., Frago, L.M., Chowen, J.A., Ruiz-Gayo, M., Cano González, Victoria

“…The aim of the current study was to evaluate the influence of HFD on the functionality of LepR by quantifying phosphorylated levels of 705Tyr-STAT3 in…”
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Ghrelin treatment protects lactotrophs from apoptosis in the pituitary of diabetic rats by Granado, M., Chowen, J.A., García-Cáceres, C., Delgado-Rubín, A., Barrios, V., Castillero, E., Argente, J., Frago, L.M.

“…Poorly controlled diabetes is associated with hormonal imbalances, including decreased prolactin production partially due to increased lactotroph apoptosis. In…”
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Saturated and unsaturated fat diets impair hippocampal glutamatergic transmission in adolescent mice by Fernández-Felipe, J., Merino, B., Sanz-Martos, A.B., Plaza, A., Contreras, A., Naranjo, V., Morales, L., Chowen, J.A., Cano, V., Ruiz-Gayo, M., Del Olmo, N.

“…Consumption of high-fat diets (HFD) has been associated with neuronal plasticity deficits and cognitive disorders linked to the alteration of glutamatergic…”
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Insulin resistance in prepubertal obese children correlates with sex-dependent early onset metabolomic alterations by Mastrangelo, A, Martos-Moreno, G Á, García, A, Barrios, V, Rupérez, F J, Chowen, J A, Barbas, C, Argente, J

“…Background: Insulin resistance (IR) is usually the first metabolic alteration diagnosed in obese children and the key risk factor for development of…”
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Growth Hormone-Releasing Peptide-6 Increases Insulin-Like Growth Factor-I mRNA Levels and Activates Akt in RCA-6 Cells as a Model of Neuropeptide Y Neurones by Frago, L. M., Pañeda, C., Argente, J., Chowen, J. A.

“…Chronic systemic administration of growth hormone (GH)‐releasing peptide‐6 (GHRP‐6), an agonist for the ghrelin receptor, to normal adult rats increases…”
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Estrogen, astrocytes and the neuroendocrine control of metabolism by Fuente-Martin, E., Garcia-Caceres, C., Morselli, E., Clegg, D. J., Chowen, J. A., Finan, B., Brinton, R. D., Tschöp, M. H.

“…Obesity, and its associated comorbidities such as type 2 diabetes, cardiovascular diseases, and certain cancers, represent major health challenges…”
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Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells: evidence for a role of GLP-1 receptor agonists as an inhibitory signal for food and water intake by Navarro, M, Rodriquez de Fonseca, F, Alvarez, E, Chowen, J A, Zueco, J A, Gomez, R, Eng, J, Blázquez, E

“…This study was designed to determine the possible role of brain glucagon-like peptide-1 (GLP-1) receptors in feeding behavior. In situ hybridization showed…”
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Gonadal hormones as promoters of structural synaptic plasticity: cellular mechanisms by García-Segura, L M, Chowen, J A, Párducz, A, Naftolin, F

“…It is now obvious that the CNS is capable of undergoing a variety of plastic changes at all stages of development. Although the magnitude and distribution of…”
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The number of lactotrophs is reduced in the anterior pituitary of streptozotocin-induced diabetic rats by ARROBA, A. I, FRAGO, L. M, PANEDA, C, ARGENTE, J, CHOWEN, J. A

“…Prolactin secretion is often reduced in insulin dependent diabetes mellitus, but little is known about the mechanism involved. Since changes in the hormonal…”
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Exposure to increased levels of estradiol during development can have long-term effects on the response to undernutrition in female rats by Carrillo, B., Collado, P., Díaz, F., Chowen, J. A., Pinos, H.

“…Objectives: Undernutrition during development alters the expression of peptides that control energy expenditure and feeding behavior. Estrogens can also…”
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