Search Results - "Chowdhury, Ekram Ahmed"

In vitro modeling of the neurovascular unit: advances in the field by Bhalerao, Aditya, Sivandzade, Farzane, Archie, Sabrina Rahman, Chowdhury, Ekram Ahmed, Noorani, Behnam, Cucullo, Luca

“…The blood-brain barrier (BBB) is a fundamental component of the central nervous system. Its functional and structural integrity is vital in maintaining the…”
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Current progress and limitations of AAV mediated delivery of protein therapeutic genes and the importance of developing quantitative pharmacokinetic/pharmacodynamic (PK/PD) models by Chowdhury, Ekram Ahmed, Meno-Tetang, Guy, Chang, Hsueh Yuan, Wu, Shengjia, Huang, Hsien Wei, Jamier, Tanguy, Chandran, Jayanth, Shah, Dhaval K.

“…While protein therapeutics are one of the most successful class of drug molecules, they are expensive and not suited for treating chronic disorders that…”
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Brain Energy Metabolism in Ischemic Stroke: Effects of Smoking and Diabetes by Sifat, Ali Ehsan, Nozohouri, Saeideh, Archie, Sabrina Rahman, Chowdhury, Ekram Ahmed, Abbruscato, Thomas J

“…Proper regulation of energy metabolism in the brain is crucial for maintaining brain activity in physiological and different pathophysiological conditions…”
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LC–MS/MS-based in vitro and in vivo investigation of blood–brain barrier integrity by simultaneous quantitation of mannitol and sucrose by Noorani, Behnam, Chowdhury, Ekram Ahmed, Alqahtani, Faleh, Ahn, Yeseul, Patel, Dhavalkumar, Al-Ahmad, Abraham, Mehvar, Reza, Bickel, Ulrich

“…Background Understanding the pathophysiology of the blood brain-barrier (BBB) plays a critical role in diagnosis and treatment of disease conditions. Applying…”
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Advanced Microfluidic Vascularized Tissues as Platform for the Study of Human Diseases and Drug Development by Noorani, Behnam, Cucullo, Luca, Ahn, Yeseul, Kadry, Hossam, Bhalerao, Aditya, Raut, Snehal, Nozohouri, Ehsan, Chowdhury, Ekram Ahmed

“…The vascular system plays a critical role in human physiology and diseases. It is a complex subject to study using in vitro models due to its dynamic and…”
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Understanding the brain uptake and permeability of small molecules through the BBB: A technical overview by Chowdhury, Ekram Ahmed, Noorani, Behnam, Alqahtani, Faleh, Bhalerao, Aditya, Raut, Snehal, Sivandzade, Farzane, Cucullo, Luca

“…The brain is the most important organ in our body requiring its unique microenvironment. By the virtue of its function, the blood-brain barrier poses a…”
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Investigation of Antibody Pharmacokinetics in the Brain Following Intra-CNS Administration and Development of PBPK Model to Characterize the Data by Wu, Shengjia, Chang, Hsueh-Yuan, Chowdhury, Ekram Ahmed, Huang, Hsien Wei, Shah, Dhaval K.

“…Despite the promising potential of direct central nervous system (CNS) antibody administration to enhance brain exposure, there remains a significant gap in…”
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Brain Uptake of [ 13 C] and [ 14 C]Sucrose Quantified by Microdialysis and Whole Tissue Analysis in Mice by Alqahtani, Faleh, Chowdhury, Ekram Ahmed, Bhattacharya, Raktima, Noorani, Behnam, Mehvar, Reza, Bickel, Ulrich

“…Among small, hydrophilic drug-like molecules, [ C]sucrose has long been considered the gold standard for determination of blood-brain barrier permeability…”
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Effects of Volatile Anesthetics versus Ketamine on Blood-Brain Barrier Permeability via Lipid-Mediated Alterations of Endothelial Cell Membranes by Noorani, Behnam, Chowdhury, Ekram Ahmed, Alqahtani, Faleh, Ahn, Yeseul, Nozohouri, Ehsan, Zoubi, Sumaih, Patel, Dhavalkumar, Wood, Laurence, Huang, Juyang, Siddique, Muhammad Bilal, Al-Ahmad, Abraham, Mehvar, Reza, Bickel, Ulrich

“…The purpose of this study was to investigate the effects of the volatile anesthetic agents isoflurane and sevoflurane, at clinically relevant concentrations,…”
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Simultaneous UPLC–MS/MS analysis of two stable isotope labeled versions of sucrose in mouse plasma and brain samples as markers of blood-brain barrier permeability and brain vascular space by Chowdhury, Ekram Ahmed, Alqahtani, Faleh, Bhattacharya, Raktima, Mehvar, Reza, Bickel, Ulrich

“…•Blood-brain barrier permeability is frequently measured in studies of brain disease.•Correction for brain intravascular content of permeability markers is…”
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Enrichment of the erythrocyte miR-451a in brain extracellular vesicles following impairment of the blood-brain barrier by Koopaei, Nasser Nassiri, Chowdhury, Ekram Ahmed, Jiang, Jinmai, Noorani, Behnam, da Silva, Lais, Bulut, Gamze, Hakimjavadi, Hesamedin, Chamala, Srikar, Bickel, Ulrich, Schmittgen, Thomas D.

“…•The blood-brain barrier of mice was disrupted by unilateral intracarotid artery infusion with hyperosmolar mannitol solution and revealed a 14-fold increase…”
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Towards a translational physiologically-based pharmacokinetic (PBPK) model for receptor-mediated transcytosis of anti-transferrin receptor monoclonal antibodies in the central nervous system by Chang, Hsueh-Yuan, Wu, Shengjia, Chowdhury, Ekram Ahmed, Shah, Dhaval K.

“…In this manuscript, we present a translational physiologically-based pharmacokinetic (PBPK) model to characterize receptor-mediated transcytosis (RMT) of…”
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Assessment of AAV9 distribution and transduction in rats after administration through Intrastriatal, Intracisterna magna and Lumbar Intrathecal routes by Chandran, Jayanth, Chowdhury, Ekram Ahmed, Perkinton, Michael, Jamier, Tanguy, Sutton, Daniel, Wu, Shengjia, Dobson, Claire, Shah, Dhaval K., Chessell, Iain, Meno-Tetang, Guy M. L.

“…Challenges in obtaining efficient transduction of brain and spinal cord following systemic AAV delivery have led to alternative administration routes being…”
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A Semi-Physiological Three-Compartment Model Describes Brain Uptake Clearance and Efflux of Sucrose and Mannitol after IV Injection in Awake Mice by Noorani, Behnam, Chowdhury, Ekram Ahmed, Alqahtani, Faleh, Sajib, Md Sanaullah, Ahn, Yeseul, Nozohouri, Ehsan, Patel, Dhavalkumar, Mikelis, Constantinos, Mehvar, Reza, Bickel, Ulrich

“…Purpose To evaluate a three-compartmental semi-physiological model for analysis of uptake clearance and efflux from brain tissue of the hydrophilic markers…”
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