Search Results - "Chow, Lionel"

Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis by Lavado, Alfonso, Lagutin, Oleg V, Chow, Lionel M L, Baker, Suzanne J, Oliver, Guillermo

“…The dentate gyrus has an important role in learning and memory, and adult neurogenesis in the subgranular zone of the dentate gyrus may play a role in the…”
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MELK‐Dependent FOXM1 Phosphorylation is Essential for Proliferation of Glioma Stem Cells by Joshi, Kaushal, Banasavadi‐Siddegowda, Yeshavanth, Mo, Xiaokui, Kim, Sung‐Hak, Mao, Ping, Kig, Cenk, Nardini, Diana, Sobol, Robert W., Chow, Lionel M.L., Kornblum, Harley I., Waclaw, Ronald, Beullens, Monique, Nakano, Ichiro

“…Glioblastoma multiforme (GBM) is a life‐threatening brain tumor. Accumulating evidence suggests that eradication of glioma stem‐like cells (GSCs) in GBM is…”
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Digital sorting of complex tissues for cell type-specific gene expression profiles by Zhong, Yi, Wan, Ying-Wooi, Pang, Kaifang, Chow, Lionel M L, Liu, Zhandong

“…Cellular heterogeneity is present in almost all gene expression profiles. However, transcriptome analysis of tissue specimens often ignores the cellular…”
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Cooperativity within and among Pten, p53, and Rb Pathways Induces High-Grade Astrocytoma in Adult Brain by Chow, Lionel M.L., Endersby, Raelene, Zhu, Xiaoyan, Rankin, Sherri, Qu, Chunxu, Zhang, Junyuan, Broniscer, Alberto, Ellison, David W., Baker, Suzanne J.

“…Mutations in the PTEN, TP53, and RB1 pathways are obligate events in the pathogenesis of human glioblastomas. We induced various combinations of deletions in…”
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Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain by Rafalski, Victoria A., Ho, Peggy P., Brett, Jamie O., Ucar, Duygu, Dugas, Jason C., Pollina, Elizabeth A., Chow, Lionel M. L., Ibrahim, Adiljan, Baker, Suzanne J., Barres, Ben A., Steinman, Lawrence, Brunet, Anne

“…Oligodendrocytes—the myelin-forming cells of the central nervous system—can be regenerated during adulthood. In adults, new oligodendrocytes originate from…”
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Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells by Cicero, Samantha A, Johnson, Dianna, Reyntjens, Steve, Frase, Sharon, Connell, Samuel, Chow, Lionel M.L, Baker, Suzanne J, Sorrentino, Brian P, Dyer, Michael A

“…It was previously reported that the ciliary epithelium (CE) of the mammalian eye contains a rare population of cells that could produce clonogenic…”
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PTEN function in normal and neoplastic growth by Chow, Lionel M.L., Baker, Suzanne J.

“…The PTEN tumor suppressor is a central negative regulator of the PI3K/AKT signaling cascade that influences multiple cellular functions including cell growth,…”
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Induced Telomere Damage to Treat Telomerase Expressing Therapy-Resistant Pediatric Brain Tumors by Sengupta, Satarupa, Sobo, Matthew, Lee, Kyungwoo, Senthil Kumar, Shiva, White, Angela R, Mender, Ilgen, Fuller, Christine, Chow, Lionel M L, Fouladi, Maryam, Shay, Jerry W, Drissi, Rachid

“…Brain tumors remain the leading cause of cancer-related deaths in children and often are associated with long-term sequelae among survivors of current…”
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Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK by Liu, Xiaona, Chhipa, Rishi Raj, Pooya, Shabnam, Wortman, Matthew, Yachyshin, Sara, Chow, Lionel M. L., Kumar, Ashish, Zhou, Xuan, Sun, Ying, Quinn, Brian, McPherson, Christopher, Warnick, Ronald E., Kendler, Ady, Giri, Shailendra, Poels, Jeroen, Norga, Koenraad, Viollet, Benoit, Grabowski, Gregory A., Dasgupta, Biplab

“…The multifunctional AMPK-activated protein kinase (AMPK) is an evolutionarily conserved energy sensor that plays an important role in cell proliferation,…”
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IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma by Kofuji, Satoshi, Hirayama, Akiyoshi, Eberhardt, Alexander Otto, Kawaguchi, Risa, Sugiura, Yuki, Sampetrean, Oltea, Ikeda, Yoshiki, Warren, Mikako, Sakamoto, Naoya, Kitahara, Shuji, Yoshino, Hirofumi, Yamashita, Daisuke, Sumita, Kazutaka, Wolfe, Kara, Lange, Lisa, Ikeda, Satsuki, Shimada, Hiroko, Minami, Noriaki, Malhotra, Akshiv, Morioka, Shin, Ban, Yuki, Asano, Maya, Flanary, Victoria L., Ramkissoon, Annmarie, Chow, Lionel M. L., Kiyokawa, Juri, Mashimo, Tomoyuki, Lucey, Greg, Mareninov, Sergey, Ozawa, Tatsuya, Onishi, Nobuyuki, Okumura, Koichi, Terakawa, Jumpei, Daikoku, Takiko, Wise-Draper, Trisha, Majd, Nazanin, Kofuji, Kaori, Sasaki, Mika, Mori, Masaru, Kanemura, Yonehiro, Smith, Eric P., Anastasiou, Dimitrios, Wakimoto, Hiroaki, Holland, Eric C., Yong, William H., Horbinski, Craig, Nakano, Ichiro, DeBerardinis, Ralph J., Bachoo, Robert M., Mischel, Paul S., Yasui, Wataru, Suematsu, Makoto, Saya, Hideyuki, Soga, Tomoyoshi, Grummt, Ingrid, Bierhoff, Holger, Sasaki, Atsuo T.

“…In many cancers, high proliferation rates correlate with elevation of rRNA and tRNA levels, and nucleolar hypertrophy. However, the underlying mechanisms…”
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A phase I/II study of ribociclib following radiation therapy in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG) by DeWire, Mariko, Fuller, Christine, Hummel, Trent R., Chow, Lionel M. L., Salloum, Ralph, de Blank, Peter, Pater, Luke, Lawson, Sarah, Zhu, Xiaoting, Dexheimer, Phil, Carle, Adam C., Kumar, Shiva Senthil, Drissi, Rachid, Stevenson, Charles B., Lane, Adam, Breneman, John, Witte, David, Jones, Blaise V., Leach, James L., Fouladi, Maryam

“…Purpose Cyclin-dependent kinase-retinoblastoma (CDK-RB) pathway is dysregulated in some diffuse intrinsic pontine gliomas (DIPG). We evaluated safety,…”
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Intracranial growing teratoma syndrome (iGTS): an international case series and review of the literature by Michaiel, George, Strother, Douglas, Gottardo, Nicholas, Bartels, Ute, Coltin, Hallie, Hukin, Juliette, Wilson, Beverly, Zelcer, Shayna, Hansford, Jordan R., Hassall, Timothy, AbdelBaki, Mohamed S., Cole, Kristina A., Hoffman, Lindsey, Smiley, Natasha P., Smith, Amy, Vinitsky, Anna, Vitanza, Nicholas A., Wright, Avery, Yeo, Kee K., Chow, Lionel M. L., Vanan, Magimairajan I., Dhall, Girish, Bouffet, Eric, Lafay-Cousin, Lucie

“…Purpose Intracranial growing teratoma syndrome (iGTS) is a rare phenomenon of paradoxical growth of a germ cell tumor (GCT) during treatment despite…”
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Overcoming barriers to establishing autopsy procurement programs in pediatric patients with central nervous system tumors: a call to develop regional centers by DeWire, Mariko, Erker, Craig, Hummel, Trent R., Chow, Lionel M. L, de Blank, Peter, Salloum, Ralph, Pillay-Smiley, Natasha, Hoffman, Lindsey, Gilger, Elizabeth, Gallagher, Maureen, Driver, Lori, Meister, Dinah, Ward, Heather, Drissi, Rachid, Kumar, Shiva Senthil, Sengupta, Satarupa, Kikta, Bridget, Meriwether, Wanda, Jelinek, Susan, Asher, Anthony, Jones, Blaise, Leach, James, Miles, Lili, Fuller, Christine, Fouladi, Maryam

“…Background While autopsy-repository programs with a variety of pediatric central nervous system (CNS) tumor types are a critical resource for preclinical…”
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AMP kinase promotes glioblastoma bioenergetics and tumour growth by Chhipa, Rishi Raj, Fan, Qiang, Anderson, Jane, Muraleedharan, Ranjithmenon, Huang, Yan, Ciraolo, Georgianne, Chen, Xiaoting, Waclaw, Ronald, Chow, Lionel M., Khuchua, Zaza, Kofron, Matthew, Weirauch, Matthew T., Kendler, Ady, McPherson, Christopher, Ratner, Nancy, Nakano, Ichiro, Dasgupta, Nupur, Komurov, Kakajan, Dasgupta, Biplab

“…Stress is integral to tumour evolution, and cancer cell survival depends on stress management. We found that cancer-associated stress chronically activates the…”
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AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival by Muraleedharan, Ranjithmenon, Gawali, Mruniya V., Tiwari, Durgesh, Sukumaran, Abitha, Oatman, Nicole, Anderson, Jane, Nardini, Diana, Bhuiyan, Mohammad Alfrad Nobel, Tkáč, Ivan, Ward, Amber Lynne, Kundu, Mondira, Waclaw, Ronald, Chow, Lionel M., Gross, Christina, Rao, Raghavendra, Schirmeier, Stefanie, Dasgupta, Biplab

“…Lactate is used as an energy source by producer cells or shuttled to neighboring cells and tissues. Both glucose and lactate fulfill the bioenergetic demand of…”
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PTEN Signaling in the Postnatal Perivascular Progenitor Niche Drives Medulloblastoma Formation by Zhu, Guo, Rankin, Sherri L, Larson, Jon D, Zhu, Xiaoyan, Chow, Lionel M L, Qu, Chunxu, Zhang, Jinghui, Ellison, David W, Baker, Suzanne J

“…Loss of the tumor suppressor gene PTEN exerts diverse outcomes on cancer in different developmental contexts. To gain insight into the effect of its loss on…”
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Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas by Salloum, Ralph, McConechy, Melissa K, Mikael, Leonie G, Fuller, Christine, Drissi, Rachid, DeWire, Mariko, Nikbakht, Hamid, De Jay, Nicolas, Yang, Xiaodan, Boue, Daniel, Chow, Lionel M L, Finlay, Jonathan L, Gayden, Tenzin, Karamchandani, Jason, Hummel, Trent R, Olshefski, Randal, Osorio, Diana S, Stevenson, Charles, Kleinman, Claudia L, Majewski, Jacek, Fouladi, Maryam, Jabado, Nada

“…Pediatric high-grade gliomas (pHGGs) are aggressive neoplasms representing approximately 20% of brain tumors in children. Current therapies offer limited…”
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Inducible Cre recombinase activity in mouse mature astrocytes and adult neural precursor cells by Chow, Lionel M. L, Zhang, Junyuan, Baker, Suzanne J

“…Two transgenic mouse lines expressing an inducible form of the Cre recombinase (CreERTM) under the control of the human GFAP promoter have been generated and…”
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Pten deletion causes mTorc1-dependent ectopic neuroblast differentiation without causing uniform migration defects by Zhu, Guo, Chow, Lionel M L, Bayazitov, Ildar T, Tong, Yiai, Gilbertson, Richard J, Zakharenko, Stanislav S, Solecki, David J, Baker, Suzanne J

“…Neuronal precursors, generated throughout life in the subventricular zone, migrate through the rostral migratory stream to the olfactory bulb where they…”
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Magnetic resonance imaging-guided microdialysis cannula implantation in a spontaneous high-grade glioma murine model by Elmeliegy, Mohamed A, Carcaboso, Angel M, L Chow, Lionel M, Zhang, Ziwei M, Calabrese, Christopher, Throm, Stacy L, Wang, Fan, Baker, Suzanne J, Stewart, Clinton F

“…Cerebral microdialysis is used to study anticancer drug penetration in the central nervous system (CNS) and brain tumors in animal models. Genetically…”
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