Search Results - "Chow, Jesse C"

Respiratory syncytial virus fusion protein-induced toll-like receptor 4 (TLR4) signaling is inhibited by the TLR4 antagonists Rhodobacter sphaeroides lipopolysaccharide and eritoran (E5564) and requires direct interaction with MD-2 by Rallabhandi, Prasad, Phillips, Rachel L, Boukhvalova, Marina S, Pletneva, Lioubov M, Shirey, Kari Ann, Gioannini, Theresa L, Weiss, Jerrold P, Chow, Jesse C, Hawkins, Lynn D, Vogel, Stefanie N, Blanco, Jorge C G

“…Respiratory syncytial virus (RSV) is a leading cause of infant mortality worldwide. Toll-like receptor 4 (TLR4), a signaling receptor for structurally diverse…”
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A novel class of endotoxin receptor agonists with simplified structure, toll-like receptor 4-dependent immunostimulatory action, and adjuvant activity by Hawkins, Lynn D, Ishizaka, Sally T, McGuinness, Pamela, Zhang, Huiming, Gavin, Wendy, DeCosta, Bruce, Meng, Zhaoyang, Yang, Hu, Mullarkey, Maureen, Young, Donna W, Yang, Hua, Rossignol, Daniel P, Nault, Anneliese, Rose, Jeffrey, Przetak, Melinda, Chow, Jesse C, Gusovsky, Fabian

“…A series of novel, synthetic compounds containing lipids linked to a phosphate-containing acyclic backbone are shown to have similar biological properties to…”
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The Extra Domain A of Fibronectin Activates Toll-like Receptor 4 by Okamura, Yoshinori, Watari, Michiko, Jerud, Elliot S., Young, Donna W., Ishizaka, Sally T., Rose, Jeffrey, Chow, Jesse C., Strauss, Jerome F.

“…Cellular fibronectin, which contains an alternatively spliced exon encoding type III repeat extra domain A (EDA), is produced in response to tissue injury…”
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Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction by Chow, J C, Young, D W, Golenbock, D T, Christ, W J, Gusovsky, F

“…TLR4 is a member of the recently identified Toll-like receptor family of proteins and has been putatively identified as Lps, the gene necessary for potent…”
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Insulin-like Growth Factor-I Receptor Internalization Regulates Signaling via the Shc/Mitogen-activated Protein Kinase Pathway, but Not the Insulin Receptor Substrate-1 Pathway by Chow, J C, Condorelli, G, Smith, R J

“…Insulin-like growth factor-I (IGF-I) receptors activate divergent signaling pathways by phosphorylating multiple cellular proteins, including insulin receptor…”
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A Novel Synthetic Acyclic Lipid A-like Agonist Activates Cells via the Lipopolysaccharide/Toll-like Receptor 4 Signaling Pathway by Lien, Egil, Chow, Jesse C., Hawkins, Lynn D., McGuinness, Pamela D., Miyake, Kensuke, Espevik, Terje, Gusovsky, Fabian, Golenbock, Douglas T.

“…ER-112022 is a novel acyclic synthetic lipid A analog that contains six symmetrically organized fatty acids on a noncarbohydrate backbone. Chinese hamster…”
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Toll-like receptor 2 antagonists. Part 1: Preliminary SAR investigation of novel synthetic phospholipids by Spyvee, Mark R., Zhang, Huiming, Hawkins, Lynn D., Chow, Jesse C.

“…Phospholipid compound 1 was discovered as a novel antagonist of toll-like receptor 2 signaling. Synthesis and biological properties are described for 1 and…”
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Sustained endotoxemia leads to marked down-regulation of early steps in the insulin-signaling cascade by McCowen, Karen C, Ling, Pei Ra, Ciccarone, Annamaria, Mao, Yilei, Chow, Jesse C, Bistrian, Bruce R, Smith, Robert J

“…OBJECTIVESTo determine the effects of sustained, 3-day endotoxin infusion on early steps of the insulin-signaling pathway in rat liver and skeletal muscle in…”
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Cellular Events Mediated by Lipopolysaccharide-stimulated Toll-like Receptor 4 by Yang, Hua, Young, Donna W., Gusovsky, Fabian, Chow, Jesse C.

“…Lipopolysaccharide (LPS) stimulates multiple signaling events, including nuclear factor-κB (NF-κB) activity and the mitogen-activated protein (MAP) kinases,…”
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Leptin Signaling in the Hypothalamus of Normal Rats in VivoThis work was supported in part by a Boston Obesity Nutrition Research Center Grant (to J.C.C.), NIH Grant DK-50411 (to R.J.S.), and NIH Diabetes and Endocrinology Center Grant DK-36836 (to R.J.S.) by McCowen, Karen C., Chow, Jesse C., Smith, Robert J.

“…Leptin has been shown to activate multiple signaling molecules in cultured cells, including Janus kinase-2, STAT (signal transducer and activator of…”
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Molecular Genetic Analysis of an Endotoxin Nonresponder Mutant Cell Line by Schromm, Andra B., Lien, Egil, Henneke, Philipp, Chow, Jesse C., Yoshimura, Atsutoshi, Heine, Holger, Latz, Eicke, Monks, Brian G., Schwartz, David A., Miyake, Kensuke, Golenbock, Douglas T.

“…Somatic cell mutagenesis is a powerful tool for characterizing receptor systems. We reported previously two complementation groups of mutant cell lines derived…”
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Cellular events mediated by lipopolysaccharide-stimulated toll-like receptor 4. MD-2 is required for activation of mitogen-activated protein kinases and Elk-1 by Yang, H, Young, D W, Gusovsky, F, Chow, J C

“…Lipopolysaccharide (LPS) stimulates multiple signaling events, including nuclear factor-kappaB (NF-kappaB) activity and the mitogen-activated protein (MAP)…”
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Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling by Schromm, A B, Lien, E, Henneke, P, Chow, J C, Yoshimura, A, Heine, H, Latz, E, Monks, B G, Schwartz, D A, Miyake, K, Golenbock, D T

“…Somatic cell mutagenesis is a powerful tool for characterizing receptor systems. We reported previously two complementation groups of mutant cell lines derived…”
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Gluconeogenic dependence on ketogenesis in isolated sheep hepatocytes by Chow, J C, Planck-Meyer, C, Jesse, B W

“…Dependence of gluconeogenesis on beta-oxidation and ketogenesis from long-chain fatty acids was examined in isolated sheep hepatocytes. Hepatocytes were…”
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The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts by Laviola, L, Giorgino, F, Chow, J C, Baquero, J A, Hansen, H, Ooi, J, Zhu, J, Riedel, H, Smith, R J

“…To identify receptor-associated proteins that may contribute to the specificity of insulin and IGF-I signaling responses, a mouse embryo library was screened…”
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Gut adaptation and the insulin-like growth factor system: regulation by glutamine and IGF-I administration by Ziegler, T R, Mantell, M P, Chow, J C, Rombeau, J L, Smith, R J

“…Intestinal adaptation after extensive small bowel resection in rats is augmented by the provision of diets supplemented with the amino acid glutamine (Gln) or…”
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Growth hormone stimulates tyrosine phosphorylation of JAK2 and STAT5, but not insulin receptor substrate-1 or SHC proteins in liver and skeletal muscle of normal rats in vivo by Chow, J C, Ling, P R, Qu, Z, Laviola, L, Ciccarone, A, Bistrian, B R, Smith, R J

“…GH has been shown to stimulate tyrosine phosphorylation of JAK2, several STAT proteins, insulin receptor substrate-1 (IRS-1), and SHC proteins in cultured…”
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Greater Sensitivity of IRS-1 than SHC to Activation by Insulin Receptors Determines Cell-Specific Signaling Responses by FEDERICI, MASSIMO, GIOVANNONE, BARBARA, CHOW, JESSE C, SMITH, ROBERT J

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Leptin Signaling in the Hypothalamus of Normal Rats in Vivo1 by McCowen, Karen C, Chow, Jesse C, Smith, Robert J

“…Leptin has been shown to activate multiple signaling molecules in cultured cells, including Janus kinase-2, STAT (signal transducer and activator of…”
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Chronic growth hormone treatment in normal rats reduces post-prandial skeletal muscle plasma membrane GLUT1 content, but not glucose transport or GLUT4 expression and localization by Napoli, R, Cittadini, A, Chow, J C, Hirshman, M F, Smith, R J, Douglas, P S, Horton, E S

“…Whether skeletal muscle glucose transport system is impaired in the basal, post-prandial state during chronic growth hormone treatment is unknown. The current…”
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