T Cell Receptor Vβ Repertoire Expression Reflects Gastric Carcinoma Progression

T Cell Receptor Vβ Repertoire Expression Reflects Gastric Carcinoma Progression

Analysis of TCR β-chain complementarity-determining region size gives an indication of the T cell immune response. We examined CD4+ and CD8+ subgroups of T cells in the peripheral blood (PBL), benign gastric mucosa, and tumor (TIL) lymphocytes of 12 patients with primary gastric carcinomas of both i...

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Bibliographic Details
Published in:Clinical immunology (Orlando, Fla.) Vol. 101; no. 1; pp. 3 - 7
Main Authors: Zhang, X.Y., Chan, W.Y., Whitney, B.M., Fan, D.M., Chow, J.H.S., Liu, Y., Ng, E.K.W., Chung, S.C.S.
Format: Journal Article
Language:English
Published: San Diego, CA Elsevier Inc 01-10-2001
Elsevier
Subjects:
Biological and medical sciences
depth of invasion
gastric carcinoma
Gastroenterology. Liver. Pancreas. Abdomen
histologic type
lymph node metastases
Medical sciences
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
TCRVβ
Tumors
TCRVβ
depth of invasion
lymph node metastases
gastric carcinoma
histologic type
Human
Stomach
Carcinoma
Immune response
Spirillales
Spirillaceae
Malignant tumor
Metastasis
Cell subpopulation
Helicobacter pylori
Immunological investigation
T-Lymphocyte
Tumor progression
Digestive diseases
Bacteria
Lymphatic dissemination
α/β T cell receptor
Immunologic repertoire
Gastric disease
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Summary:Analysis of TCR β-chain complementarity-determining region size gives an indication of the T cell immune response. We examined CD4+ and CD8+ subgroups of T cells in the peripheral blood (PBL), benign gastric mucosa, and tumor (TIL) lymphocytes of 12 patients with primary gastric carcinomas of both intestinal and diffuse types. The average number of expanded clones in each compartment, expressed by the 24 families of the TCRVβ repertoire, was analyzed according to tumor histological type, maximal invasive depth, and lymph node metastases. Fewer clones were expressed by the PBL in the cases with lymph node metastases than in those without (CD4+P = 0.00017, CD8+P = 0.016). Fewer CD8+ clones were expressed by the PBL in the cases with full thickness tumor infiltration than in those involving only the mucosa and submucosa (P = 0.05). The CD8+ TIL showed significantly fewer clones in the diffuse-type carcinoma than in the intestinal type (P = 0.046).
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1521-6616
1521-7035
DOI:10.1006/clim.2001.5100