Search Results - "Chow, Diana S L"

Simultaneous inhibition of hedgehog signaling and tumor proliferation remodels stroma and enhances pancreatic cancer therapy by Zhao, Jun, Wang, Huamin, Hsiao, Cheng-Hui, Chow, Diana S.-L., Koay, Eugene J., Kang, Yaan, Wen, Xiaoxia, Huang, Qian, Ma, Ying, Bankson, James A., Ullrich, Stephen E., Overwijk, Willem, Maitra, Anirban, Piwnica-Worms, David, Fleming, Jason B., Li, Chun

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers. It has an excessive desmoplastic stroma that can limit the intratumoral delivery of…”
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Characterization of Polymyxin B Biodistribution and Disposition in an Animal Model by Manchandani, Pooja, Zhou, Jian, Ledesma, Kimberly R, Truong, Luan D, Chow, Diana S-L, Eriksen, Jason L, Tam, Vincent H

“…Despite dose-limiting nephrotoxicity concerns, polymyxin B has resurged as the treatment of last resort for multidrug-resistant Gram-negative bacterial…”
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Pharmacokinetics and efficacy of liposomal polymyxin B in a murine pneumonia model by He, Jie, Abdelraouf, Kamilia, Ledesma, Kimberly R, Chow, Diana S.-L, Tam, Vincent H

“…Abstract Polymyxin B (PB) is increasingly used as the last treatment for multidrug-resistant (MDR) Gram-negative bacterial infections. In this study, serum and…”
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Analytical and functional determination of polymyxin B protein binding in serum by Abodakpi, Henrietta, Gohlke, Jie, Chang, Kai-Tai, Chow, Diana S-L, Tam, Vincent H

“…To enhance our understanding of the pharmacological properties of polymyxin B, serum protein binding for polymyxin B1, B2, and B3 and for isoleucine-polymyxin…”
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Doxorubicin-loaded hollow gold nanospheres for dual photothermal ablation and chemoembolization therapy by Sheth, Rahul A., Wen, Xiaoxia, Li, Junjie, Melancon, Marites P., Ji, Xin, Andrew Wang, Y., Hsiao, Cheng-Hui, Chow, Diana S.-L., Whitley, Elizabeth M., Li, Chun, Gupta, Sanjay

“…Background Doxorubicin-loaded hollow gold nanospheres (Dox@HAuNS) are a promising technology for simultaneous trans-arterial tumor-targeted chemotherapy…”
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Pharmacokinetic Basis for Using Saliva Matrine Concentrations as a Clinical Compliance Monitoring in Antitumor B Chemoprevention Trials in Humans by Bui, Dinh, McWilliams, Lenora A, Wu, Lei, Zhou, Haiying, Wong, Stuart J, You, Ming, Chow, Diana S-L, Singh, Rashim, Hu, Ming

“…This study reports the first clinical evidence of significantly high secretion of matrine in a multi-component botanical (Antitumor B, ATB) into human saliva…”
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Pharmacokinetic Variability of Mycophenolic Acid in Pediatric and Adult Patients With Hematopoietic Stem Cell Transplantation by Zhang, Daping, Renbarger, Jamie L., Chow, Diana S-L.

“…The aim of this study was to evaluate the pharmacokinetic variations of mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil (MMF), in both…”
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Development and validation of a highly sensitive LC–MS/MS assay for the quantification of arginine vasopressin in human plasma and urine: Application in preterm neonates and child by Zhang, Daping, Rios, Danielle R., Tam, Vincent H., Chow, Diana S.-L.

“…•UPLC–MS/MS is highly sensitive for the quantification of arginine vasopressin.•AVP levels determined by UPLC–MS/MS are consistent with the published data.•The…”
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Simultaneous quantification of mycophenolic acid and its glucuronide metabolites in human plasma by an UPLC-MS/MS assay by Zhang, Daping, Chow, Diana S-L., Renbarger, Jamie L.

“…The aim of this study was to develop a reliable UPLC–MS/MS assay for accurate quantification of mycophenolic acid (MPA) and its glucuronide conjugates in human…”
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Pharmacokinetic Model Analysis of Supralingual, Oral and Intravenous Deliveries of Mycophenolic Acid by Gao, Xiuqing, Wu, Lei, Tsai, Robert Y L, Ma, Jing, Liu, Xiaohua, Chow, Diana S-L, Liang, Dong, Xie, Huan

“…Mycophenolic acid (MPA) is commonly used for organ rejection prophylaxis via oral administration in the clinic. Recent studies have shown that MPA also has…”
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Variability of polymyxin B major components in commercial formulations by He, Jie, Ledesma, Kimberly R, Lam, Wai-Ying, Figueroa, Deborah A, Lim, Tze-Peng, Chow, Diana S.-L, Tam, Vincent H

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Development & validation of LC–MS/MS assay for 5-amino-1-methyl quinolinium in rat plasma: Application to pharmacokinetic and oral bioavailability studies by Awosemo, Ololade, Neelakantan, Harshini, Watowich, Stanley, Ma, Jing, Wu, Lei, Chow, Diana S.-L., Liang, Dong

“…•A simple, specific and reproducible LC–MS/MS assay for 5-AMQ in rat plasma and urine was developed and validated.•The assay was used to characterize…”
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Longitudinal Impacts of Gastric Bypass Surgery on Pharmacodynamics and Pharmacokinetics of Statins by El-Zailik, Asma, Cheung, Lily K., Wang, Yang, Sherman, Vadim, Chow, Diana S.-L.

“…Purpose Undergoing Roux-en-Y gastric bypass (RYGB) is expected to affect orally administered drug absorption. Statins are commonly prescribed to patients with…”
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Delayed post-injury administration of riluzole is neuroprotective in a preclinical rodent model of cervical spinal cord injury by Wu, Yongchao, Satkunendrarajah, Kajana, Teng, Yang, Chow, Diana S-L, Buttigieg, Josef, Fehlings, Michael G

“…Riluzole, a sodium/glutamate antagonist has shown promise as a neuroprotective agent. It is licensed for amyotrophic lateral sclerosis and is in clinical trial…”
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Stem Cell Theory of Cancer: Implications for Drug Resistance and Chemosensitivity in Cancer Care by Tu, Shi-Ming, Guo, Charles C, Chow, Diana S-L, Zacharias, Niki M

“…When it concerns cancer care and cancer therapy, drug resistance is more than an obstacle to successful treatment; it is a major cause of frustration in our…”
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A prospective, multicenter, phase I matched-comparison group trial of safety, pharmacokinetics, and preliminary efficacy of riluzole in patients with traumatic spinal cord injury by Grossman, Robert G, Fehlings, Michael G, Frankowski, Ralph F, Burau, Keith D, Chow, Diana S L, Tator, Charles, Teng, Angela, Toups, Elizabeth G, Harrop, James S, Aarabi, Bizhan, Shaffrey, Christopher I, Johnson, Michele M, Harkema, Susan J, Boakye, Maxwell, Guest, James D, Wilson, Jefferson R

“…A prospective, multicenter phase I trial was undertaken by the North American Clinical Trials Network (NACTN) to investigate the pharmacokinetics and safety…”
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A validated ultra-performance liquid chromatography-tandem mass spectrometry method for the quantification of polymyxin B in mouse serum and epithelial lining fluid: application to pharmacokinetic studies by He, Jie, Gao, Song, Hu, Ming, Chow, Diana S-L, Tam, Vincent H

“…A rapid, sensitive and robust ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed for the quantification of four…”
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Clinical Pharmacokinetics of Mycophenolic Acid in Hematopoietic Stem Cell Transplantation Recipients by Zhang, Daping, Chow, Diana S.-L.

“…Mycophenolate mofetil (MMF), an ester prodrug of mycophenolic acid (MPA), is widely used as a maintenance immunosuppressive regimen in solid organ transplant…”
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Longitudinal Impact of Acute Spinal Cord Injury on Clinical Pharmacokinetics of Riluzole, a Potential Neuroprotective Agent by Nguyen, Ashley, Chow, Diana S‐L., Wu, Lei, Teng, Yang (Angela), Sarkar, Mahua, Toups, Elizabeth G., Harrop, James S., Schmitt, Karl M., Johnson, Michele M., Guest, James D., Aarabi, Bizhan, Shaffrey, Christopher I., Boakye, Maxwell, Frankowski, Ralph F., Fehlings, Michael G., Grossman, Robert G.

“…Riluzole, a benzothiazole sodium channel blocker that received US Food and Drug Administration approval to attenuate neurodegeneration in amyotrophic lateral…”
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UPLC–MS/MS assay of riluzole in human plasma and cerebrospinal fluid (CSF): Application in samples from spinal cord injured patients by Sarkar, Mahua, Grossman, Robert G., Toups, Elizabeth G., Chow, Diana S.-L.

“…•Development and validation of UPLC–MS/MS assay of riluzole in human plasma and CSF.•Assay validation as per US FDA Bioanalytical Method Validation: Guidance…”
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