Search Results - "Chow, D D"

Deep-Learning Convolutional Neural Networks Accurately Classify Genetic Mutations in Gliomas by Chang, P, Grinband, J, Weinberg, B D, Bardis, M, Khy, M, Cadena, G, Su, M-Y, Cha, S, Filippi, C G, Bota, D, Baldi, P, Poisson, L M, Jain, R, Chow, D

“…The World Health Organization has recently placed new emphasis on the integration of genetic information for gliomas. While tissue sampling remains the…”
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Rationale, design and critical end points for the Riluzole in Acute Spinal Cord Injury Study (RISCIS): a randomized, double-blinded, placebo-controlled parallel multi-center trial by Fehlings, M G, Nakashima, H, Nagoshi, N, Chow, D S L, Grossman, R G, Kopjar, B

“…Background: Riluzole is a sodium channel-blocking agent used in treating amyotrophic lateral sclerosis. It has been approved by the U.S. Food and Drug…”
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The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2 by Chow, Ryan D., Majety, Medha, Chen, Sidi

“…Age is a major risk factor for severe coronavirus disease-2019 (COVID-19). Here, we interrogate the transcriptional features and cellular landscape of the…”
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Hybrid 3D/2D Convolutional Neural Network for Hemorrhage Evaluation on Head CT by Chang, P D, Kuoy, E, Grinband, J, Weinberg, B D, Thompson, M, Homo, R, Chen, J, Abcede, H, Shafie, M, Sugrue, L, Filippi, C G, Su, M-Y, Yu, W, Hess, C, Chow, D

“…Convolutional neural networks are a powerful technology for image recognition. This study evaluates a convolutional neural network optimized for the detection…”
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Depletion of Abundant Sequences by Hybridization (DASH): using Cas9 to remove unwanted high-abundance species in sequencing libraries and molecular counting applications by Gu, W, Crawford, E D, O'Donovan, B D, Wilson, M R, Chow, E D, Retallack, H, DeRisi, J L

“…Next-generation sequencing has generated a need for a broadly applicable method to remove unwanted high-abundance species prior to sequencing. We introduce…”
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Rapid pathogen detection by metagenomic next-generation sequencing of infected body fluids by Gu, Wei, Deng, Xianding, Lee, Marco, Sucu, Yasemin D., Arevalo, Shaun, Stryke, Doug, Federman, Scot, Gopez, Allan, Reyes, Kevin, Zorn, Kelsey, Sample, Hannah, Yu, Guixia, Ishpuniani, Gurpreet, Briggs, Benjamin, Chow, Eric D., Berger, Amy, Wilson, Michael R., Wang, Candace, Hsu, Elaine, Miller, Steve, DeRisi, Joseph L., Chiu, Charles Y.

“…We developed a metagenomic next-generation sequencing (mNGS) test using cell-free DNA from body fluids to identify pathogens. The performance of mNGS testing…”
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The role of bile acids in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis by Chow, Monica D., Lee, Yi-Horng, Guo, Grace L.

“…Nonalcoholic fatty liver disease is growing in prevalence worldwide. It is marked by the presence of macrosteatosis on liver histology but is often clinically…”
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Nonsteroidal Anti-inflammatory Drugs Dampen the Cytokine and Antibody Response to SARS-CoV-2 Infection by Chen, Jennifer S, Alfajaro, Mia Madel, Chow, Ryan D, Wei, Jin, Filler, Renata B, Eisenbarth, Stephanie C, Wilen, Craig B

“…Identifying drugs that regulate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its symptoms has been a pressing area of…”
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Artificial Intelligence and Acute Stroke Imaging by Soun, J E, Chow, D S, Nagamine, M, Takhtawala, R S, Filippi, C G, Yu, W, Chang, P D

“…Artificial intelligence technology is a rapidly expanding field with many applications in acute stroke imaging, including ischemic and hemorrhage subtypes…”
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Mapping the Genetic Landscape of Human Cells by Horlbeck, Max A., Xu, Albert, Wang, Min, Bennett, Neal K., Park, Chong Y., Bogdanoff, Derek, Adamson, Britt, Chow, Eric D., Kampmann, Martin, Peterson, Tim R., Nakamura, Ken, Fischbach, Michael A., Weissman, Jonathan S., Gilbert, Luke A.

“…Seminal yeast studies have established the value of comprehensively mapping genetic interactions (GIs) for inferring gene function. Efforts in human cells…”
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The DNA methylation landscape of advanced prostate cancer by Zhao, Shuang G., Chen, William S., Li, Haolong, Foye, Adam, Zhang, Meng, Sjöström, Martin, Aggarwal, Rahul, Playdle, Denise, Liao, Arnold, Alumkal, Joshi J., Das, Rajdeep, Chou, Jonathan, Hua, Junjie T., Barnard, Travis J., Bailey, Adina M., Chow, Eric D., Perry, Marc D., Dang, Ha X., Yang, Rendong, Moussavi-Baygi, Ruhollah, Zhang, Li, Alshalalfa, Mohammed, Laura Chang, S., Houlahan, Kathleen E., Shiah, Yu-Jia, Beer, Tomasz M., Thomas, George, Chi, Kim N., Gleave, Martin, Zoubeidi, Amina, Reiter, Robert E., Rettig, Matthew B., Witte, Owen, Yvonne Kim, M., Fong, Lawrence, Spratt, Daniel E., Morgan, Todd M., Bose, Rohit, Huang, Franklin W., Li, Hui, Chesner, Lisa, Shenoy, Tanushree, Goodarzi, Hani, Asangani, Irfan A., Sandhu, Shahneen, Lang, Joshua M., Mahajan, Nupam P., Lara, Primo N., Evans, Christopher P., Febbo, Phillip, Batzoglou, Serafim, Knudsen, Karen E., He, Housheng H., Huang, Jiaoti, Zwart, Wilbert, Costello, Joseph F., Luo, Jianhua, Tomlins, Scott A., Wyatt, Alexander W., Dehm, Scott M., Ashworth, Alan, Gilbert, Luke A., Boutros, Paul C., Farh, Kyle, Chinnaiyan, Arul M., Maher, Christopher A., Small, Eric J., Quigley, David A., Feng, Felix Y.

“…Although DNA methylation is a key regulator of gene expression, the comprehensive methylation landscape of metastatic cancer has never been defined. Through…”
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Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury by Tata, Aleksandra, Kobayashi, Yoshihiko, Chow, Ryan D., Tran, Jasmine, Desai, Avani, Massri, Abdull J., McCord, Timothy J., Gunn, Michael Dee, Tata, Purushothama Rao

“…Cells demonstrate plasticity following injury, but the extent of this phenomenon and the cellular mechanisms involved remain underexplored. Using single-cell…”
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Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution by Yang, Dian, Jones, Matthew G., Naranjo, Santiago, Rideout, William M., Min, Kyung Hoi (Joseph), Ho, Raymond, Wu, Wei, Replogle, Joseph M., Page, Jennifer L., Quinn, Jeffrey J., Horns, Felix, Qiu, Xiaojie, Chen, Michael Z., Freed-Pastor, William A., McGinnis, Christopher S., Patterson, David M., Gartner, Zev J., Chow, Eric D., Bivona, Trever G., Chan, Michelle M., Yosef, Nir, Jacks, Tyler, Weissman, Jonathan S.

“…Tumor evolution is driven by the progressive acquisition of genetic and epigenetic alterations that enable uncontrolled growth and expansion to neighboring and…”
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A web tool for the design of prime-editing guide RNAs by Chow, Ryan D., Chen, Jennifer S., Shen, Johanna, Chen, Sidi

“…Prime editing enables diverse genomic alterations to be written into target sites without requiring double-strand breaks or donor templates. The design of…”
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AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma by Chow, Ryan D, Guzman, Christopher D, Wang, Guangchuan, Schmidt, Florian, Youngblood, Mark W, Ye, Lupeng, Errami, Youssef, Dong, Matthew B, Martinez, Michael A, Zhang, Sensen, Renauer, Paul, Bilguvar, Kaya, Gunel, Murat, Sharp, Phillip A, Zhang, Feng, Platt, Randall J, Chen, Sidi

“…Using an adeno-associated virus–mediated, direct in vivo CRISPR screen, the authors mapped a quantitative landscape of glioblastoma suppressors. Their study…”
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The development and realisation of a multi-faceted system for green building planning: A case in Ningbo using the fuzzy analytical hierarchy process by Li, Zhilei, Chow, D.H.C, Ding, De, Ying, Jia, Hu, Yingjian, Chen, Hong, Zhao, Wei

“…After the Green Building Regulations in the Zhejiang Province was put into effect in May 2016, cities and prefectures in the province were given directives to…”
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Pulmonary Metagenomic Sequencing Suggests Missed Infections in Immunocompromised Children by Zinter, Matt S, Dvorak, Christopher C, Mayday, Madeline Y, Iwanaga, Kensho, Ly, Ngoc P, McGarry, Meghan E, Church, Gwynne D, Faricy, Lauren E, Rowan, Courtney M, Hume, Janet R, Steiner, Marie E, Crawford, Emily D, Langelier, Charles, Kalantar, Katrina, Chow, Eric D, Miller, Steve, Shimano, Kristen, Melton, Alexis, Yanik, Gregory A, Sapru, Anil, DeRisi, Joseph L

“…Abstract Background Despite improved diagnostics, pulmonary pathogens in immunocompromised children frequently evade detection, leading to significant…”
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Multiplexed activation of endogenous genes by CRISPRa elicits potent antitumor immunity by Wang, Guangchuan, Chow, Ryan D., Bai, Zhigang, Zhu, Lvyun, Errami, Youssef, Dai, Xiaoyun, Dong, Matthew B., Ye, Lupeng, Zhang, Xiaoya, Renauer, Paul A., Park, Jonathan J., Shen, Li, Ye, Hanghui, Fuchs, Charles S., Chen, Sidi

“…Immunotherapy has transformed cancer treatment. However, current immunotherapy modalities face various limitations. In the present study, we developed…”
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Systematic Genetic Analysis of Virulence in the Human Fungal Pathogen Cryptococcus neoformans by Liu, Oliver W., Chun, Cheryl D., Chow, Eric D., Chen, Changbin, Madhani, Hiten D., Noble, Suzanne M.

“…The fungus Cryptococcus neoformans is a leading cause of mortality and morbidity among HIV-infected individuals. We utilized the completed genome sequence and…”
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Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes by Ravindra, Neal G, Alfajaro, Mia Madel, Gasque, Victor, Huston, Nicholas C, Wan, Han, Szigeti-Buck, Klara, Yasumoto, Yuki, Greaney, Allison M, Habet, Victoria, Chow, Ryan D, Chen, Jennifer S, Wei, Jin, Filler, Renata B, Wang, Bao, Wang, Guilin, Niklason, Laura E, Montgomery, Ruth R, Eisenbarth, Stephanie C, Chen, Sidi, Williams, Adam, Iwasaki, Akiko, Horvath, Tamas L, Foxman, Ellen F, Pierce, Richard W, Pyle, Anna Marie, van Dijk, David, Wilen, Craig B

“…There are currently limited Food and Drug Administration (FDA)-approved drugs and vaccines for the treatment or prevention of Coronavirus Disease 2019…”
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