Search Results - "Chow, Christine S"

A cross-institutional analysis of the effects of broadening trainee professional development on research productivity by Brandt, Patrick D, Sturzenegger Varvayanis, Susi, Baas, Tracey, Bolgioni, Amanda F, Alder, Janet, Petrie, Kimberly A, Dominguez, Isabel, Brown, Abigail M, Stayart, C. Abigail, Singh, Harinder, Van Wart, Audra, Chow, Christine S, Mathur, Ambika, Schreiber, Barbara M, Fruman, David A, Bowden, Brent, Wiesen, Christopher A, Golightly, Yvonne M, Holmquist, Chris E, Arneman, Daniel, Hall, Joshua D, Hyman, Linda E, Gould, Kathleen L, Chalkley, Roger, Brennwald, Patrick J, Layton, Rebekah L

“…PhD-trained scientists are essential contributors to the workforce in diverse employment sectors that include academia, industry, government, and nonprofit…”
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Increasing faculty support, respect, and ability to help doctoral students explore non-academic research career opportunities by Mathur, Ambika, Hwalek, Melanie, Straub, Victoria, Chow, Christine S.

“…We examined the role of the NIH-funded Broadening Experiences in Scientific Training (BEST) program at Wayne State University in increasing faculty (1) support…”
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Production of Nanostructures of DNA on Surfaces by Liu, Maozi, Amro, Nabil A, Chow, Christine S, Liu, Gang-yu

“…Nanopatterns of thiolated single-stranded DNA (ssDNA) are produced by using an atomic force microscopy (AFM)-based lithography technique known as nanografting…”
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Exposure to multiple career pathways by biomedical doctoral students at a public research university by Mathur, Ambika, Chow, Christine S, Feig, Andrew L, Kenaga, Heidi, Moldenhauer, Judith A, Muthunayake, Nisansala S, Ouellett, Mathew L, Pence, Laura E, Straub, Victoria

“…The Broadening Experiences in Scientific Experiences (BEST) program at Wayne State University was designed to increase doctoral students' awareness of multiple…”
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Cisplatin Targeting of Bacterial Ribosomal RNA Hairpins by Dedduwa-Mudalige, Gayani N P, Chow, Christine S

“…Cisplatin is a clinically important chemotherapeutic agent known to target purine bases in nucleic acids. In addition to major deoxyribonucleic acid (DNA)…”
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Chemical probing for examining the structure of modified RNAs and ligand binding to RNA by Waduge, Prabuddha, Sakakibara, Yogo, Chow, Christine S.

“…[Display omitted] •Pseudouridine is a post transcriptionally modified nucleotide found in the helix 69 of prokaryotic 23S ribosomal RNA.•Pseudouridine plays a…”
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Post-transcriptional Modifications Modulate rRNA Structure and Ligand Interactions by Jiang, Jun, Seo, Hyosuk, Chow, Christine S

“…Post-transcriptional modifications play important roles in modulating the functions of RNA species. The presence of modifications in RNA may directly alter its…”
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Calculated pKa Values for a Series of Aza- and Deaza-Modified Nucleobases by Mlotkowski, Alan J, Schlegel, H Bernhard, Chow, Christine S

“…A variety of synthetic modified nucleobases have been used to investigate the structure and function of RNA and DNA or act as enzyme inhibitors. A set of these…”
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Selection of peptides targeting helix 31 of bacterial 16S ribosomal RNA by screening M13 phage-display libraries by Lamichhane, Tek N, Abeydeera, N Dinuka, Duc, Anne-Cécile E, Cunningham, Philip R, Chow, Christine S

“…Ribosomal RNA is the catalytic portion of ribosomes, and undergoes a variety of conformational changes during translation. Structural changes in ribosomal RNA…”
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Calculated p K a Values for a Series of Aza- and Deaza-Modified Nucleobases by Mlotkowski, Alan J, Schlegel, H Bernhard, Chow, Christine S

“…A variety of synthetic modified nucleobases have been used to investigate the structure and function of RNA and DNA or act as enzyme inhibitors. A set of these…”
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A Structural Basis for RNA−Ligand Interactions by Chow, Christine S, Bogdan, Felicia M

“…An examination provides an overview of RNA-ligand interactions structure and specific binding modes. The future development of RNA-targeting drugs will rely on…”
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Amino acid-linked platinum(II) analogues have altered specificity for RNA compared to cisplatin by Rijal, Keshab, Bao, Xun, Chow, Christine S

“…Cisplatin can be modified with various ligands to alter the size and charge distribution of the complex. Several amino acid-linked platinum(II) complexes were…”
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Calculations of pKa Values for a Series of Naturally Occurring Modified Nucleobases by Jones, Evan L, Mlotkowski, Alan J, Hebert, Sebastien P, Schlegel, H Bernhard, Chow, Christine S

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Use of a fluorescence assay to determine relative affinities of semisynthetic aminoglycosides to small RNAs representing bacterial and mitochondrial A sites by Waduge, Prabuddha, Sati, Girish C., Crich, David, Chow, Christine S.

“…The off-target binding of aminoglycosides (AGs) to the A site of human mitochondrial ribosomes in addition to bacterial ribosomes causes ototoxicity and limits…”
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Synthesis and solution conformation studies of 3-substituted uridine and pseudouridine derivatives by Chang, Yu-Cheng, Herath, Jayatilake, Wang, Tony H.-H., Chow, Christine S.

“…A series of 3-substituted uridine and pseudouridine derivatives, based on the naturally occurring 3-(3-amino-3-carboxypropyl) modification, were synthesized…”
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Pseudouridine modifications influence binding of aminoglycosides to helix 69 of bacterial ribosomes by Sakakibara, Yogo, Chow, Christine S

“…Development of antibiotics that target new regions of functionality is a possible way to overcome antibiotic resistance. In this study, the interactions of…”
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Combined Approaches to Site-Specific Modification of RNA by Chow, Christine S, Mahto, Santosh K, Lamichhane, Tek N

“…Both natural and unnatural modifications in RNA are of interest to biologists and chemists. More than 100 different analogues of the four standard RNA…”
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Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens by Matsushita, Takahiko, Sati, Girish C, Kondasinghe, Nuwan, Pirrone, Michael G, Kato, Takayuki, Waduge, Prabuddha, Kumar, Harshitha Santhosh, Sanchon, Adrian Cortes, Dobosz-Bartoszek, Malgorzata, Shcherbakov, Dimitri, Juhas, Mario, Hobbie, Sven N, Schrepfer, Thomas, Chow, Christine S, Polikanov, Yury S, Schacht, Jochen, Vasella, Andrea, Böttger, Erik C, Crich, David

“…Infectious diseases due to multidrug-resistant pathogens, particularly carbapenem-resistant Enterobacteriaceae (CREs), present a major and growing threat to…”
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A modified fluorescent intercalator displacement assay for RNA ligand discovery by Asare-Okai, Papa Nii, Chow, Christine S.

“…Fluorescent intercalator displacement (FID) is a convenient and practical tool for identifying new nucleic acid-binding ligands. The success of FID is based on…”
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Expression and In Vivo Characterization of the Antimicrobial Peptide Oncocin and Variants Binding to Ribosomes by Muthunayake, Nisansala S, Islam, Rabiul, Inutan, Ellen D, Colangelo, Wesley, Trimpin, Sarah, Cunningham, Philip R, Chow, Christine S

“…Peptides have important biomedical applications, but poor correlation between in vitro and in vivo activities can limit their development for clinical use. The…”
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